INTRODUCTION 1
Ⅰ．STRUCTURE AND ACTIVITY 9
Ⅱ．BIOLOGICAL ASPECTS OF TUMOUR INDUCTION 38
General Characteristics of Tumours 38
Pathology of Induced Tumours 42
Sex Differences and Tumour Induction 51
Age and Tumour Induction 53
Hereditary Differences and Tumour Induction 54
Species Differences and Tumour Induction 59
Influence of the Diet on Tumour Induction 62
Ⅲ．TEST METHODS 68
Mode of Administration 68
Solvent Effects 70
Anti-and Co-carcinogenesis 75
Dosage，Latent Period，Tumour Incidence and the Carcinogenic Index 80
Ⅳ．THEORIES OF THE MODE OF ACTION OF CARCINOGENS 96
Ⅴ．BIOGENETIC RELATIONSHIPS 132
Ⅵ．METABOLISM OF CARCINOGENIC HYDROCARBONS 153
Ⅶ．CARCINOGENIC AZO COMPOUNDS 174
Ⅷ．CARCINOGENIC AROMATIC AMINES AND DERIVATIVES 210
APPENDIX Ⅰ．Some Chemical Carcinogens 222
APPENDIX Ⅱ．Inhibition of Tumour Growth and Possibilities of Tumour Chemotherapy 227
GENERAL REVIEWS 238
INDEX 239
PLATES 42
Ⅰ．Keratinising skin carcinoma in mouse，induced by benzpyrene 42
Ⅱ．Keratinising skin carcinoma in mouse，induced by benzpyrene．A more advanced stage than previous plate 43
Ⅲ．Spindle-celled sarcoma induced in a Strong A mouse by 0．25 mg．methylcholanthrene 44
Ⅳ．Adenocarcinoma of lung induced by methylcholanthrene in a Strong A mouse 45
Ⅴ．Liver of Wistar rat fed dimethylaminoazobenzene with low protein diet for four months．Cholangioma showing a typical formation of new ducts 48