贺林院士集PDF电子书下载

第一部分 奋斗历程 1

贺林小传 3

贺林传记 5

第二部分 学术贡献 17

一、贺林院士的主要学术论文 19

精神分裂症的基因组学研究进展 19

精神分裂症中拷贝数变异的研究新进展 30

转化医学：从基础科研到临床应用 36

Mutations in IHH，Encoding Indian Hedgehog，Cause Brachydactyly Type A-1 42

A Family-Based and Case-Control Association Study of the NOTCH4 Gene and Schizophrenia 47

Family-Based Association Studies of COMT Gene Polymorphisms and Schizophrenia in the Chinese Population 52

Family-Based Association Study of DTNBP1 in 6 p22.3 and Schizophrenia 54

Polymorphisms within 5′End of the Neuregulin 1 Gene are Genetically Associated with Schizophrenia in the Chinese Population 56

Association of SNPs and Haplotypes in GABAA Receptor β2 Gene with Schizophrenia 58

No Association Between Polymorphisms of Methylenetetrahydrofolate Reductase Gene and Schizophrenia in Both Chinese and Scottish Populations 66

SHEsis，a Powerful Software Platform for Analyses of Linkage Disequilibrium,Haplotype Construction，and Genetic Association at Polymorphism Loci 69

Rates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959-1961 71

Further Evidence for the Association Between G72/G30 Genes and Schizophrenia in Two Ethnically Distinct Populations 78

Family-Based Association Study of Epsin 4 and Schizophrenia 88

MPZL1/PZR,a Novel Candidate Predisposing Schizophrenia in Han Chinese 93

Meta-Analysis Supports Association Between Serotonin transporter（5-HTT）and Suicidal Behavior 98

A Study of Rare Structural Variants in Schizophrenia Patients and Normal Controls from Chinese Han Population 107

Identification of Loci Associated with Schizophrenia by Genome-wide Association and Follow-up 110

A Mutation in Ihh that Causes Digit Abnormalities Alters its Signalling Capacity and range 115

A Partition-Ligation-Combination-Subdivision EM Algorithm for Haplotype Inference with Multiallelic Markers：Update of the SHEsis（http：//analysis.bio-x.cn） 125

Copy-Number Mutations on Chromosome 17q24.2-q24.3 in Congenital Generalized Hypertrichosis Terminalis with or without Gingival Hyperplasia 129

The Sequence and de Novo Assembly of the Giant Panda Genome 137

Asymmetric DNA Origami for Spatially Addressable and Index-Free Solution-Phase DNA Chips 147

SHEsisEpi,A GPU-Enhanced Genome-Wide SNP-SNP Interaction Scanning Algorithm,Efficiently Reveals the Risk Genetic Epistasis in Bipolar Disorder 153

Analysis of 10 Independent Samples Provides Evidence for Association Between Schizop-hrenia and a SNP Flanking Fibroblast Growth Factor Receptor 2（FGFR2） 157

Common Variants in Major Histocompatibility Complex Region and TCF4 Gene are Significantly Associated with Schizophrenia in Han Chinese 165

A Positive Role for c-Abl in Atm and Atr Activation in DNA Damage Response 169

Genome-Wide Association Study Identifies Susceptibility Loci for Polycystic Ovary Syndrome on Chromosome 2p16.3,2p21 and 9q33.3 184

Common Variants in the BCL9 Gene Conferring Risk of Schizophrenia 192

Common SNPs and Haplotypes in DGK H are Associated with Bipolar Disorder and Schizophrenia in the Chinese Han Population 203

A Genome-Wide Association Study Reveals Association Between Common Variants in An Intergenic Region of 4q25 and High-Grade Myopia in the Chinese Han Population 206

Indian Hedgehog Mutations Causing Brachydactyly Type A1 Impair Hedgehog Signal Transduction at Multiple Levels 215

Gold Nanoparticles for High-Throughput Genotyping of Long-Range Haplotypes 229

Common Variants on 8p12 and lq24.2 Confer Risk of Schizophrenia 237

NMDA Receptor Hypofunction Induces Dysfunctions of Energy Metabolism and Semaphorin Signaling in Rats：A Synaptic Proteome Study 243

GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers 257

Genome-wide Association Study in Han Chinese Identifies four New Susceptibility Loci for Coronary Artery Disease 268

Genome-Wide Association Study Identifies Eight New Risk Loci for Polycystic Ovary Syndrome 275

Genetic Variants at 6p21.1 and 7p15.3 Are Associated with Risk of Multiple Cancers in Han Chinese 283

ORIGINAL ARTICLE Potential metabolite markers of schizophrenia 291

二、贺林院士学术年表 304

（一）代表论文 304

（二）论文总目录 304

（三）参与的学术会议 350

（四）主要成绩 360

（五）承担课题 361

（六）专利申请 362

第三部分 治学之道 365

贺林“既然要做，为什么不做得最好？” 367

贺林院士：做一件事，就要努力做到最好 372

第四部分 大师风范 377

在科学的殿堂里实现自己的梦想 379

贺林：遗传生物学家的X魅力 383

中国出生缺陷问题的探讨 387

破译中国人的“遗传密码” 389

第五部分 社会影响 393

临床转化医学研究中心无锡成立 395

大熊猫钟情竹子的原因有答案 396

基因“失活”大熊猫不爱吃肉 397

2001年中国医药科技十大新闻揭晓 398

人类短指症病因终被揭开 400

上海交大破解短指症病因 402

2011年上海科技奖揭晓交大获奖数十年居首贺林院士荣获2011年度上海市科技功臣奖［图］ 403

［交大两会代表言论］政协委员贺林：加强出生缺陷研究 405

Bio-X研究院贺林院士应邀演讲于世博名人堂 407

贺林教授当选为中国侨联特聘科技专家、中国侨联科技专家委员会副主任 408

贺林院士当选为第二十届TWAS发展中国家科学2009年度生物奖的贺词（1） 409

贺林院士当选为第二十届TWAS发展中国家科学2009年度生物奖的贺词（2） 410

贺林院士当选为第二十一届TWAS院士的贺词 411

两成果入选2009年度中国基础科学研究十大新闻［图］ 412

不仅是个头衔更是一份责任 414

基因定位［步步快半拍］ 416

上海市科技功臣、上海交通大学Bio-X研究院院长贺林快乐科学 418

快乐“帅才” 420

“创新是城市活力和后劲所在” 422

上海科学技术奖公布 周良辅、贺林获“科技功臣奖” 424

周良辅、贺林获科技功臣奖 425

感谢信 426

第六部分 人生风采 427

家庭 431

海外留学、工作 432

科研、教学、社会活动 435

国际交流 443

业余生活 446