INDEX 1
VOLUME 1 1
INDEX 1
1.BIOLOGY OF THE NORMAL JOINT 1
Section Ⅰ BIOLOGY OF THE NORMAL JOINT 1
2.COLLAGEN AND ELASTIN 27
3.MATRIX GLYCOPROTEINS,PROTEOGLYCANS,AND CARTILAGE 41
4.PROTEINASES AND MATRIX DEGRADATION 55
5.BIOMECHANICS OF JOINTS 73
6.MACROPHAGES,DENDRITIC CELLS,AND FOLLICULAR DENDRITIC CELLS 79
Section Ⅱ IMMUNE AND INFLAMMATORY RESPONSES 79
7.GENETICS OF RHEUMATIC DISEASES 95
8.T LYMPHOCYTES 113
9.B CELLS 131
10.RHEUMATOID FACTOR 151
11.ANTINUCLEAR ANTIBODIES 161
12.IMMUNE COMPLEXES 175
13.COMPLEMENT 185
14.NEUTROPHILS AND EOSINOPHILS 195
15.PROSTAGLANDINS,LEUKOTRIENES,AND RELATED COMPOUNDS 211
16.THE MAST CELL 225
17.ENDOTHELIAL CELLS AND NITRIC OXIDE 239
18.PLATELETS 255
19.FIBROBLAST FUNCTION AND FIBROSIS 263
20.CYTOKINES 275
21.APOPTOSIS 291
22.AUTOIMMUNITY 305
Section Ⅲ EVALUATION OF THE PATIENT 321
23.EPIDEMIOLOGY OF THE RHEUMATIC DISEASES 321
24.EVIDENCE-BASED RHEUMATOLOGY 335
25.EXAMINATION OF THE JOINTS 347
26.MONARTICULAR ARTHRITIS 367
27.POLYARTICULAR ARTHRITIS 379
28.WEAKNESS 387
29.THE EYE AND RHEUMATIC DISEASE 393
30.THE SKIN 401
Section Ⅳ MUSCULOSKELETAL PAIN AND EVALUATION 417
31.FIBROMYALGIA 417
32.OCCUPATIONAL AND RECREATIONAL MUSCULOSKELETAL DISORDERS 429
33.SPORTS MEDICINE 439
34.NECK PAIN 457
35.SHOULDER PAIN 475
36.LOW BACK PAIN 509
37.HIP AND KNEE PAIN 525
38.ANKLE AND FOOT PAIN 547
39.TEMPOROMANDIBULAR JOINT PAIN 557
40.HAND AND WRIST PAIN 569
Section Ⅴ DIAGNOSTIC TESTS AND PROCEDURES 583
41.ASPIRATION AND INJECTION OF JOINTS AND SOFT TISSUES 583
42.SYNOVIAL FLUID ANALYSIS AND SYNOVIAL BIOPSY 605
43.IMAGING 621
44.ARTHROSCOPY AND SYNOVECTOMY 685
45.LABORATORY EVALUATION OF INFLAMMATION 697
46.BIOLOGIC MARKERS 705
Section Ⅵ SPECIAL ISSUES 713
47.UNTRITION AND RHEUMATIC DISEASES 713
48.PSYCHOSOCIAL MANAGEMENT OF RHEUMATIC DISEASES 729
49.GERIATRICS AND THE RHEUMATIC DISEASES 735
50.ALTERNATIVE CARE FOR ARTHRITIS AND RELATED MUSCULOSKELETAL DISEASES 739
51.CHRONIC PAIN MANAGEMENT 753
52.REHABILITATION OF PATIENTS WITH RHEUMATIC DISEASES 763
53.HEALTH OUTCOME ASSESSMENT 777
Section Ⅶ CLINICAL PHARMACOLOGY 789
54.DEVELOPING A CLINICAL TRIAL DESIGN 789
55.NONSTEROIDAL ANTHNFLAMMATORY DRUGS 799
56.GLUCOCORTICOIDS 823
57.METHOTREXATE 841
58.SULFASALAZINE 853
59.ANTIMALARIAL DRUGS 859
60.GOLD AND PENICILLAMINE 869
61.IMMUNOREGULATORY DRUGS 879
62.BIOLOGIC AGENTS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS 899
63.TETRACYCLINES 913
64.ETIOLOGY AND PATHOGENESIS OF RHEUMATOID ARTHRITIS 921
Section Ⅷ RHEUMATOID ARTHRITIS 921
VOLUME 2 921
65.CLINICAL FEATURES OF RHEUMATOID ARTHRITIS 967
66.TREATMENT OF RHEUMATOID ARTHRITIS 1001
67.FELTY S SYNDROME 1023
68.APPROACHES TO THE TREATMENT OF SJOGREN S SYNDROME 1027
Section Ⅸ SPONDYLOARTHROPATHIES 1039
69.ANKYLOSING SPONDYLITIS 1039
70.REITER S SYNDROME AND UNDIFFERENTIATED SPONDYLOARTHROPATHY 1055
71.PSORIATIC ARTHRITIS 1071
72.ENTEROPATHIC ARTHRITIS 1081
Section Ⅹ SYSTEMIC LUPUS ERYTHEMATOSUS AND RELATED SYNDROMES 1089
73.PATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS 1089
74.CLINICAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS 1105
75.MANAGEMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS 1125
76.ANTIPHOSPHOLIPID ANTIBODY SYNDROME 1145
Section Ⅺ VASCULITIC SYNDROMES 1153
77.CLASSIFICATION OF VASCULITIS 1153
78.GLANT CELL ARTERITIS AND POLYMYALGIA RHEUMATICA 1155
79.VASCULITIS ASSOCIATED WITH ANTINEUTROPHIL CYTOPLASMIC ANTIBODY 1165
80.POLYARTERITIS AND RELATED DISORDERS 1185
81.HYPERSENSITIVITY VASCULITIS(SMALLVESSEL CUTANEOUS VASCULITIS) 1197
82.BEHCET S DISEASE 1205
Section Ⅻ SCLERODERMA AND MIXED CONNECTIVE TISSUE DISEASES 1211
83.SCLERODERMA 1211
84.MIXED CONNECTIVE TISSUE DISEASE AND OTHER OVERLAP SYNDROMES 1241
Section XIII STRUCTURE,FUNCTION,AND DISEASE OF MUSCLE 1261
85.SKELETAL MUSCLE 1261
86.INFLAMMATORY DISEASES OF MUSCLE AND OTHER MYOPATHIES 1273
Section XIV RHEUMATIC DISEASES OF CHILDHOOD 1297
87.JUVENILE RHEUMATOID ARTHRITIS 1297
88.SYSTEMIC LUPUS ERYTHEMATOSUS,JUVENILE DERMATOMYOSITIS,SCLERODERMA,AND VASCULITIS 1315
Section XV CRYSTAL-ASSOCIATED SYNOVITIS 1339
89.GOUT AND HYPERURICEMIA 1339
90.DISEASES ASSOCIATED WITH DEPOSITION OF CALCIUM PYROPHOSPHATE OR HYOROXYAPATITE 1377
Setion XVI OSTEOARTHRITIS,POLYCHONDRITIS,AND HERITABLE DISORDERS 1391
91.PATHOGENESIS OF OSTEOARTHRITIS 1391
92.CLINICAL FEATURES OF OSTEOARTHRITIS 1409
93.MANAGEMENT OF OSTEOARTHRITIS 1419
94.HERITABLE DISORDERS OF STRUCTURAL PROTEINS 1433
95.RELAPSING POLYCHONDRITIS 1463
Section XVII ARTHRITIS RELATED TO INFECTION 1469
96.BACTERIAL ARTHRITIS 1469
97.LYME DISEASE 1485
98.MYCOBACTERIAL AND FUNGAL INFECTIONS 1493
99.RHEUMATIC MANIFESTATIONS OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION 1507
100.VIRAL ARTHRITIS 1519
101.ACUTE RHEUMATIC FEVER 1529
Section XVIII ARTHRITIS ACCOMPANYING SYSTEMIC DISORDERS 1541
102.AMYLOIDOSIS 1541
103.SARCOIDOSIS 1551
104.IRON STORAGE DISEASE 1559
105.HEMOPHILIC ARTHROPATHY 1567
106.HEMOGLOBINOPATHIES AND ARTHRITIS 1575
107.ARTHRITIS ACCOMPANYING ENDOCRINE AND METABOLIC DISORDERS 1581
108.HYPERTROPHIC OSTEOARTHROPATHY 1589
109.MUSCULOSKELETAL SYNDROMES IN MALIGNANCY 1595
Section XIX DISORDERS OF BONE AND STRUCTURAL PROTEIN 1611
110.BIOLOGY,PHYSIOLOGY,AND MORPHOLOGY OF BONE 1611
111.METABOLIC BONE DISEASE 1635
112.OSTEONECROSIS 1653
Section XX TUMORS INVOLVING JOINTS 1667
113.TUMOR AND TUMOR-LIKE LESIONS OF JOINTS AND RELATED STRUCTURES 1667
Section XXI RECONSTRUCTIVE SURGERY FOR RHEUMATIC DISEASE 1691
114.INTRODUCTION TO SURGICAL MANAGEMENT OF PATIENTS WITH ARTHRITIS 1691
115.PRINCIPLES OF RECONSTRUCTIVE SURGERY 1699
The Hand and Wrist 1699
The Elbow 1718
The Shoulder 1728
The Cervical Spine 1736
The Hip 1743
The Knee 1759
The Ankle and Foot 1769
The Surgical Management of Juvenile RheVmatoid Arthritis 1781