1 Statement of the Clinical Oncologic Problem 1
2 The Biology of Cancer 32
3 The Pathology of Cancer 47
4 Principles of Surgical Oncology 62
5 Basic Principles of Radiobiology 75
6 Principles of Radiation Oncology and Cancer Radiotherapy 99
7 Radiation Physics as Applied to Clinical Radiation Oncology 126
8 Basic Concepts of Cancer Chemotherapy and Principles of Medical Oncology 146
9 Basic Concepts in Drug Development and Clinical Trials 160
10 Gene Therapy for Cancer 168
11 Basic Concepts of Turmor Immunology and Principles of Immunotherapy 185
12 HIV-Associated Malignancies 199
13 Oncologic Emergencies 208
14 Principles of Psychosocial Oncology 220
15 Principles of Oncologic Imaging and Tumor Imaging Strategies 241
16 Skin Cancer 252
17 Breast Cancer 267
18 Hodgkin s Disease and the Lymphomas 300
19 Pediatric Solid Tumors 336
20 Tumors of the Head and Neck 405
21 Gynecologic Tumors 462
22 Urologic and Male Genital Cancers 523
23 The Leukemias 565
24 Soft Tissue Sarcoma 615
25 Bone tumors 632
26 Cancer of the Endocrine Glands 648
27 Alimentary Cancer 685
28 Cancer of the Major Digestive Glands:Pancreas,Liver,Bile Ducts,Gallbladder 765
29 Central Nervous System Tumors 789
30 Lung Cancer 823
31 Metastases and Disseminated Disease 845
32 Cancer Pain Management:An Essential Component of Comprehensive Cancer Care 864
33 Palliative Care 893
34 Late Effects of Cancer Treatment:Radiation and Chemotherapy Toxicity 897
Glossary of Drug Terms 937
Index 941