Wellcome Building Sessions 1
Session 1：Enzymes as Primary Points of Drug Action＆Chairman：F．BERGEL 1
Chairman＇s introduction 1
Inhibition of acetylcholinesterase＆by I．B．WILSON 4
Discussion：ALDRIDGE，BECKETT，BERGEL，BLASCHKO，KREBS，R．J．P．WILLIAMS，WILSON 13
Carbonic anhydrase inhibition and physiological function＆by H．W．DAVENPORT 16
Discussion：BERGEL，BLAIR，DAVENPORT，HUNT，LUTWAK-MANN，R．J．P．WILLIAMS 27
Session 2：Active Transport＆Chairman：W．WILBRANDT 30
Pinocytosis＆by H．HOLTER 30
Discussion：GOLBERG，HOLTER，SOLS，YOUNG 39
Possible mechanisms of active transport＆by W．WILERANDT 43
Discussion：HOLTER，SMYTH，WIDDAS，WILBRANDT 57
Effects of drugs on active transport＆by K．H．BEYER and J．E．BAER 60
Discussion：BEYER，WILBRANDT 82
Session 3：Multiple Mechanisms＆Chairman：J．H．GADDUM 83
Ⅰ．Insulin 83
The explanation of the action of insulin on sugar permeability at molecular level＆by R．B．FISHER 83
Action of insulin on metabolic reactions＆by E．B．CHAIN 95
Discussion：BUSH，CHAIN，DANIELLI，de DUVE，FISHER，KEYNES，MARRACK，SOLS，WILBRANDT，WOLLENBERGER，YOUNG 110
Ⅱ．Digitalis 115
Action of cardiac glycosides on ionic movements＆by M．WEATHERALL 115
Digitalis：action on metabolism and the contractile system＆by A．WOLLENBERGER 127
Discussion：BAKER，DRAPER，EDMAN，KEYNES，WASER，WHITTAM，WOLLENBERGER 150
Ⅲ．Central Nervous System Depressants 155
Action of barbiturates upon respiratory enzymes＆by W．N．ALDRIDGE 155
Appraising enzymic actions of central depressants by examining cerebral tissues＆by H．MCILWAIN 170
Discussion：ALDRIDGE，BRADLEY，CREMER，DRAPER，JOHNSON，JUDAH，KEYNES，MCILWAIN，NICOLLS，PHILLIS，REMMER，WHITTAM，R．J．P．WILLIAMS 199
Section 4：Receptors＆Chairman：W．D．M．PATON 206
Relation between enzymes and cholinergic receptors＆by P．G．WASER 206
Discussion：COLLIER，CREESE，HOBBIGER，WASER 218
Induction of receptors＆by R．MILEDI 220
Discussion：BECKETT，DORNHORST，MILEDI，PATON，PETERS，VRBOVA，ZAIMIS 236
Session 5：Altered Drug Metabolism＆Chairman：R．T．WILLIAMS 239
Chairman＇s introduction 239
Adaptive enzymes in animals＆by W．E．KNOX 245
Discussion：BERGEL，FISHER，KNOX 274
Drug tolerance＆by H．REMMER 276
Discussion：REMMER，SCHULMAN，R．T．WILLIAMS 298
The genetics of drug sensitivity with special reference to suxamethonium＆by H．HARRIS and MARY WHITTAKER 301
Discussion：AMBACHE，BLASCHKO，DANIELLI，HARRIS，HOBBIGER，KNOX，MILEDI，SPINKS 313
Session 6：Drug Metabolism：Subcellular Aspects＆Chairman：SIR RUDOLPH PETERS 317
Drug metabolism－subcellular mechanisms＆by B．B．BRODIE 317
Discussion：BECKETT，BRODIE，LACEY，NIMMO-SMITH，REMMER，R．J．P．WILLIAMS 340
Cellular injury by drugs＆by K．R．REES 344
Protection against cellular injury by drugs＆by J．D．JUDAH 359
Discussion：ATKINSON，BRODIE，DRAPER，GOLBERG，JUDAH，O＇BRIEN，PATON，REES，REMMER，WEATHERALL 384
Session 7：Panel Discussion＆Chairman：J．F．DANIELLI 388
Speakers：ALDRIDGE，BERGEL，BLASCHKO，BRODIE，de DUVE，FISHER，GADDUM，HOLTER，JUDAH，MCILWAIN，PATON，PETERS，REMMER，SHULMAN，SMYTH，SOLS，SPINKS，WASER，WEATHERALL，WILBRANDT，R．J．P．WILLIAMS，R．T．WILLIAMSS 388
Ciba Foundation Sessions on Drug-Enzyme Interaction at the Molecular level＆Chairman：SIR HANS KREBS 401
Session 1：Enzymes 401
Introduction：Enzymes＆by J．F．DANIELLI 401
Models of active centres：acetylcholine 410
Active transport 418
Mode of action of insulin 423
Limitations of enzymes as models 429
Section 2：Receptors 435
Introductions：Receptors＆by H．O．SCHILD 435
Definition of receptors 439
Identifying active centres 443
Effect of denervation on receptors 451
Events at the cell membrane 453
Rate theory of drug action 456
Interaction at the Subcellular and Cellular Levels＆Chairman：SIR RUDOLPH PETERS 463
Session 3：Subcellular Level 463
Introduction：Membranes＆by C．DE DUVE 463
Subcellular particles 472
Phosphatidic acid cycle 478
Antihistamines and membrane permeability 481
Drug concentrations in vitro 484
Session 4：Cellular Level 487
Introduction：Cellular aspects＆by H．MCILWAIN 487
Reconstituting in vitro 488
In vitro and in vivo 494
Microsomal enzymes 497
Endoplasmic reticulum 505
Enzymes in young animals 508
Transaminase and GABA 514
Drug interactions 516
General considerations 518