Chapter 1 Next-generation Sequencing(NGS) 1
Lesson 1 From Convention to Second-generation Sequencing 2
Lesson 2 Application of Next-generation Sequencing 8
Lesson 3 First Baby Born after Full Genetic Screening of Embryos 12
Chapter 2 Big Data 25
Lesson 1 Too Much Information:Better Health from Big Data 26
Lesson 2 Life Sciences in Big Data Era 31
Lesson 3 Big Data Meets Public Health 36
Chapter 3 Personal Genomics&Personalized Medicine 48
Lesson 1 The Advent of Personal Genome Sequencing 49
Lesson 2 The Future of Personal Genomics 55
Lesson 3 Obstacles to the Translation of Personalized Medicine into the Clinic 59
Chapter 4 Animal&Plant Genome Research and Its Agricultural Applications 72
Lesson 1 Plant and Animal Sequencing 73
Lesson 2 Animal Code:Our Favorite Genomes 79
Lesson 3 Sequencing of Animal/Plant Genomes and Its Application 87
Chapter 5 Metagenomics 102
Lesson 1 Metagenomics:The Science of Biological Diversity 103
Lesson 2 How Gut Bacteria Help Make Us Fat and Thin 109
Lesson 3 Next-generation Sequencing Propels Environmental Genomics to the Front Line of Research 115
Chapter 6 Genomes and Biodiversity 128
Lesson 1 Genome 10K:a Proposal to Obtain Whole-Genome Sequence for 10000 Vertebrate Species 129
Lesson 2 Biodiversity,Genomes,and DNA Sequence Databases 135
Lesson 3 Examples of Genome&Transcriptome Projects 141
Chapter 7 Biobanking 154
Lesson 1 Current Status,Challenges,Policies&Bioethics of Biobanks 155
Lesson 2 Building Better Biobank 160
Lesson 3 Biobank Promises to Pinpoint the Cause of Disease 166
Chapter 8 Big Resources in Biobanks 178
Lesson 1 Specimen Types for DNA Net Earth 179
Lesson 2 Specimen Collections in U.S.Biobanks:Results from a National Survey 184
Lesson 3 Examples of Aquatic Biobanks Worldwide 190
Glossary 202
References 215