INTRODUCTION 1
MICROBIAL NOMENCLATURE 4
PART Ⅰ：The action of various bacterial products on malignant tumours，experi-mentally and clinically 5
1．The present position in the treatment of malignant tumours by Coley＇s method 5
2．A polysaccharide from B．prodigiosus(Serratia marcescens)and the products of certain other gram-negative bacteria 9
3．Diphtheria toxin 12
4．Lysates and filtrates of certain other bacteria 14
5．The effects of bacterial preparation 221 on transplantable and spon-taneous mouse tumours 15
6．The influence of bacteriophage on malignant tumours 16
7．The influence of viruses on malignant tumours 17
8．Filtrates of fungal cultures and the products of yeast cells 21
9．The effects on malignant tumours of antibiotics produced by the phar-maceutical industry 23
10．A cancer antibiotic from Trypanosoma cruzi 31
PART Ⅱ：Protozoan stimulators and inhibitors in relation to antibiotics of protozoan origin 37
PART Ⅲ：Infection and cancer in relation to cancer antibiotics 42
PART Ⅳ：Regression of human malignant tumours and the principles of the action of the Trypanosome substance 55
1．Regression of cancer of the lip 56
2．Regression of cancer of the vocal cord 84
3．Regression of mammary cancer 87
4．Regression of neoplasms of the gastro-intestinal tract 112
5．Regression of angiosarcoma of the skin 117
6．Regression of precancerous affections 121
7．Temporary regression and the problem of refractoriness 132
8．Defects in observation 149
9．Conclusions 165
10．The work of French investigators in the biotherapy of malignant tumours in man with the aid of an extract from Schlzotrypanum cruzi 169
PART Ⅴ：Histological and cytological changes in malignant tumours treated with the Trypanosome preparation 180
1．Observations on clinical material 181
A．Cytological analysis of tumours in patients in whom a positive effect of treatment was not established clinically or was not sufficiently well shown 182
B．Histological and cytological analysis of tumours removed atvarious stages of a positive biotherapeutic effect 196
2．Observations on tumours of laboratory animals 217
A．The influence of Trypanosome infection and the Trypano-some preparation on the Brown-Pearce carcinoma 217
B．Histological and cytological changes in the Brown-Pearce tumour under the influence of the Trypanosome preparation 218
3．The effects of the Trypanosome preparation in combination with nonradical operation 224
4．The effects of the Trypanosome preparation on spontaneous tumours of white mice 226
5．Histological and cytological changes in spontaneous tumours of mice under the influence of treatment with the Trypanosome preparation 233
PART Ⅵ：The mode of action of the antiblastic preparation from T．cruzi on cancer 246
1．Cytological and histological analysis of the mode of action of the Trypanosome preparation 246
A．Changes in nuclear size 246
B．Changes in the mitotic index 247
C．The effects of biopsy on cell multiplication in malignant tumours 248
D．Nucleolar changes 250
E．The lymphocytic and histiocytic reaction 250
F．Changes in ribonucleic acid content 253
G．Reactive changes in the connective tissue 254
H．The general principles of the cytological and histological changes occurring under the influence of the Trypanosome preparation 257
2．The influence of the Trypanosome preparation on the respiration of cancer tissue(Prof．A．M．Kuzin＇s findings) 260
3．The distribution of the Trypanosome preparation in the normal and in the cancer-affected body 265
4．The effects of T．cruzi and the Trypanosome preparation on malignant tissue in the conditions of tissue culture 267
A．The effects of T．cruzi on cultures of malignant tissue 267
B．The effects of the Trypanosome preparation on the Crocker sarcoma in vitro 269
5．The specificity of the antiblastic properties of T．cruzi 271
6．A comparison of the histological and cytological changes arising in malignant tissues under the influence of synoestrol，colchicine，B．prodigiosus polysaccharide，sarcomycin，and the cancer antibiotic from T．cruzi 277
7．Conclusions 286
PART Ⅶ：Aggressiveness and fragility in cancer cells 289
REFERENCES 297