Part I PRINCIPLES OF MOLECULAR CARDIOLOGY 1
1 General Principles of Molecular Biology[Nadia Rosenthal] 3
2 Genetic Approaches to Cardiovascular Disease[Reed Edwin Pyeritz] 19
3 Genetically Modified Animal Models in Cardiovascular Research[Stephen G. Young·Aldons J. Lusis·Robert E. Hammer] 37
4 Gene Transfer Approaches for Gardiovascular Disease[Elizabeth Nabel·Jeffrey M. Leiden] 86
Part II MORPHOGENESIS AND CARDIOVASCULAR DISEASES 113
5 Molecular Advances in Cardiovascular Development[Mark C. Fishman·Eric N. Olson·Kenneth R. Chien] 115
6 Molecular Genetics of Congenital Heart Disease [Paul D. Grossfeld·Abraham Rothman·Peter Gruber·Kenneth R. Chien] 135
Part VI PISK FACTORS FOR CORONARY ARTERY DISEASE 141
7 Inherited Vascular Disease[H. C. Dietz·V. A. McKusick] 167
Part III CARDIAC MUSCLE AND MYOPATHIES 189
8 Structure and Function Relationships in Contractile Proteins[Jeffrey Robbins·Leslie A. Leinwand] 191
9 Molecular and Cellular Biology of Cardiac Hypertrophy and Failure[Kenneth R. Chien·Andrew A. Grace·John J. Hunter] 211
10 Molecular Genetics of Inherited Cardiomyopathies[Christine E. Seidman·J. G. Seidman] 251
11 Mitochondrial Genes in Myopathy, Cardiomyopathy, and Stroke[Douglas C. Wallace·Brett Graham] 264
Part IV CARDIAC CONDUCTION AND ARRHYTHMIAS 279
12 Normal Cardiac Electrophysiology[Michael J. Ackerman·David E. Clapham] 281
13 Molecular Basis of Inherited Cardiac Arrhythmias[Mark E. Curran·Michael C. Sanguinetti·Mark T. Keating] 302
14 Molecular Approaches to Arrhythmogenesis[Eduardo Marban] 313
Part V VASCULAR BIOLOGY AND ATHEROGENESIS 329
15 Biology of the Vessel Wall: Endothelium[Michael A. Gimbrone, Jr.·James N. Topper] 331
16 Atherogenesis and Inflammation[Peter Libby·G?ran K. Hansson·Jordan S. Pober] 349
17 Restenosis Injury:A Problem in Regulation of Growth［Thomas F. Deuel·Cesario Bianchi·Lewis Cantley］ 367
18 Angiogenesis in Cardiovascular Disease［Karen S. Moulton·Judah Folkman］ 393
19 Disorders of LipoproteinMetabolism［Alan R. Tall·Marilyn Dammerman·Jon L.Breslow］ 413
20 Lipoprotein Receptiors and Cellular Cholesterol Metabolism in Health and Disease［Ira Tabas·Monty Krieger］ 428
21 Lipoproteins,Lipoprotein Oxidation,and Atherogenesis［Daniel Steinberg·Joseph L.Witztum］ 458
22 Molecular Genetics of Non-Insulin Dependent Diabetes Mellitus［Markus Stoffel］ 477
Part VII MOLECULAR BASIS OF HEMOSTASIS DISORDERS 503
23 Blood Coagulation in Cardiovascular Disease［Kenneth G.Mann·Jay M.Edelberg·Robert D.Rosenberg］ 505
24 The Fibrinolytic System and Thrombolytic Therapy[Désiré Collen·Edgar Haber] 537
25 Platelet Thrombus Formation and Antiplatelet Therapy［Zaverio M.Ruggeri·Garret A.Fitzgerald·Sanford J.shattil］ 566
Part VIII CLOSSARY OF MOLECULAR CENETICS［Kenneth R.Chien·Andrew A.Grace］ 591
lndes 615