Ⅰ.BASIC PRINCIPLES 1
1．Introduction Bertram G.Katzung,MD,PhD 1
2．Drug Receptors Pharmacodynamics Henry R.Bourne,MD, Mark von Zastrow,MD,PhD 9
3．Pharmacokinetics Pharmacodynamics:Rational Dosing the Time Course of Drug Action Nicholas H.G.Holford,MB,ChB,FRACP 35
4．Drug Biotransformation Maria Almira Correia,PhD 51
5．Basic Clinlcal Evaluation of New Drugs Barry A.Berkowitz,PhD, Bertram G.Katzung,MD,PhD 64
Ⅱ.AUTONOMIC DRUGS 75
6．Introduction to Autonomic Pharmacology Bertram G.Katzung,MD,PhD 75
7．Cholinoceptor-Activating Cholinesterase-Inhibiting Drugs Achilles J.Pappano,PhD, 92
8．Cholinoceptor-Blocking Drugs Achilles J.Pappano,PhD, Bertram G.Katzung,MD,PhD 107
9．Adrenoceptor-Activating Other Sympathomimetlc Drugs Brian B.Hoffman,MD 120
10．Adrenoceptor Antagonist Drugs Brian B.Hoffman,MD 138
Ⅲ.CARDIOVASCULAR-RENAL DRUGS 155
11．Antihypertenslve Agents Neal L.Benowitz,MD 155
12．Vasodilators the Treatment of Angina Pectorls Bertram G.Katzung,MD,PhD, Kanu Chatterjee,MB,FRCP 181
13．Cardiac Glycosides Other Drugs Used in Congestive Heart Failure Bertram G.Katzung,MD,PhD, William W.Parmley,MD 200
14．Agents Used in Cardiac Arrhythmias Luc M.Hondeghem,MD,PhD, Dan M.Roden,MD 219
15．Diuretic Agents Harlan E.Ives,MD,PhD 245
16．Histamine,Serotonin, the Ergot Alkaloids Bertram G.Katzung,MD,PhD, David J.Julius,PhD 265
Ⅳ.DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE 265
17．Vasoactive Peptides Ian A.Reid PhD 292
18．The Eicosanoids:Prostaglandins,Thromboxanes,Leukotrienes, Related Compounds Marie L.Foegh,MD,DSc, Peter W.Ramwell,PhD 311
19．Nitric Oxide,Donors, Inhibitors George Thomas,PhD, Peter W.Ramwell,PhD 326
20．Drugs Used in Asthma Homer A.Boushey,MD 333
Ⅴ.DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM 351
21．Introduction to the Pharmacology of CNS Drugs Roger A.Nicoll,MD 351
22．Sedative-Hypnotic Drugs Anthony J.Trevor,PhD, Walter L.Way,MD 364
23．The Alcohols Susan B.Masters,PhD 382
24．Antiselzure Drugs Roger J.Porter,MD, Brian S.Meldrum,MB,PhD 395
25．General Anesthetics Anthony J.Trevor,PhD, Ronald D.Miller,MD 419
26．Local Anesthetics Ronald D.Miller,MD, Bertram G.Katzung,MD,PhD 436
27．Skeietal Muscle Relaxants Ronald D.Miller,MD, Bertram G.Katzung,MD,PhD 446
28．Pharmacologic Management of Parkinsonism Other Movement Disorders Michael J.Aminoff,MD,FRCP 463
29．Antipsychotic Agents Lithium William Z.Potter,MD,PhD, Leo E.Hollister,MD 478
30．Antidepressant Agents William Z.Potter,MD,PhD, Leo E.Hollister,MD 498
31．Opioid Analgesics Antagonists Walter L.Way,MD,Howard L.Fields,MD,PhD, Mark A.Schumacher,PhD,MD 512
32．Drugs of Abuse Thomas R.Kosten,MD,and Leo E.Hollister,MD 532
Ⅵ.DRUGS USED TO TREAT DISEASES OF THE BLOOD,INFLAMMATION, GOUT 549
33．Agents Used in Anemias;Hematopoietic Growth Factors Daniel V.Santi,MD,PhD, Susan B.Masters,PhD 549
34．Drugs Used in Disorders of Coagulation Julie Hambleton,MD, Robert A.O Reilly,MD 564
35．Agents Used in Hyperlipidemia Mary J.Malloy,MD, John P.Kane,MD,PhD 581
36．Nonsteroidal Anti-Inflammatory Drugs,Disease-Modifying Antirheumatic Drugs,Nonopioid Analgesics, Drugs Used in Gout Daniel E.Furst,MD, Tino Munster,MD 596
Ⅶ.ENDOCRINE DRUGS 625
37．Hypothalamic Pituitary Hormones Paul A.Fitzgerald,MD 625
38．Thyroid Antithyroid Drugs Francls S.Greenspan,MD, Betty J.Dong,PharmD 644
39．Adrenocorticosteroids Adrenocortical Antagonists George P.Chrousos,MD, Andrew N.Margioris,MD 660
40．The Gonadal Hormones Inhibitors George P.Chrousos,MD,Emmanouil N.Zoumakis,PhD, Achille Gravanis,PhD 679
41．Pancreatic Hormones Antidlabetic Drugs Martha S.Nolte,MD, John H.Karam,MD 711
42．Agents That Affect Bone Mineral Homeostasls Daniel D.Bikle,MD,PhD 735
43．Beta-Lactam Antibiotics Other Inhibitors of Cell Wall Synthesis Henry F.Chambers,MD 754
Ⅷ.CHEMOTHERAPEUTIC DRUGS 754
44．Chloramphenicol,Tetracyclines,Macrolldes,Clindamycin, Streptogramins Henry F.Chambers,MD 774
45．Aminoglycosides Spectinomycin Henry F.Chambers,MD 784
46．Sulfonamides,Trimethoprim, Quinolones Henry F.Chambers,MD 793
47．Antimycobacterial Drugs Henry F.Chambers,MD 803
48．Antifungal Agents Don Sheppard,MD, Harry W.Lampiris,MD 814
49．Antiviral Agents Sharon Safrin,MD 823
50．Miscellaneous Antimicrobil Agents;Disinfectants,Antiseptics, Steriiants Henry F.Chambers,MD 845
51．Clinical Use of Antimicrobial Agents Harry W.Lampiris,MD, Daniel S.Maddix,PharmD 854
52．Basic Principies of Antiparasitic Chemotherapy Ching Chung Wang,PhD 869
53．Antiprotozoal Drugs Philip J.Rosenthal,MD, Robert S,Goldsmith,MD,DTM H 882
54．Clinical Pharmacology of the Anthelmintic Drugs Robert S.Goldsmith,MD,DTM H 903
55．Cancer Chemotherapy Sydney E.Salmon,MD, Alan C.Sartorelli,PhD 923
56．Immunopharmacology Douglas F.Lake,PhD,Emmanuel T.Akporiaye,PhD, Evan M.Hersh,MD 959
Ⅸ.TOXICOLOGY 987
57．Introduction to Toxicology:Occupational Environmental Gabriel L.Plaa,PhD 987
58．Heavy Metal Intoxication Chelators Michael J.Kosnett,MD,MPH 999
59．Management of the Poisoned Patlent Kent R.Olson,MD 1011
60．Special Aspects of Perinatal Pediatric Pharmacology Gideon Koren,MD 1025
Ⅹ.SPECIAL TOPICS 1025
61．Special Aspects of Geriatric Pharmacology Bertram G.Katzung,MD,PhD 1036
62．Dermatologic Pharmacology Dirk B.Robertson,MD, Howard I.Maibach,MD 1045
63．Drugs Used in Gastrointestinal Diseases David F.Altman,MD 1064
64．Therapeutic Toxic Potential of Over-the-Counter Agents Robin L.Corelli,PharmD, Mary Anne Koda-Kimble,PharmD 1077
65．Botanicals( Herbal Medications ) Nutritional Supplements Cathi E.Dennehy,PharmD, Candy Tsourounis,PharmD 1088
66．Rational Prescribing Prescription Wrlting Paul W.Lofholm,PharmD, Bertram G.Katzung,MD,PhD 1104
AppendixⅠ. Vaccines,Immune Globulins, Other Compiex Biologic Products Harry W.Lampiris,MD, Daniel S.Maddix,PharmD 1113
AppendixⅡ. Important Drug Interactions Their Mechanisms Phillp D.Hansten,PharmD 1122
Index 1135