Section I Basic Science 1
Dedication 3
1 Advances in the Study of Glial Lineage[Mark E. Linskey] 3
Special Dedication to Dr.Harry M.Zimmerman 5
Introduction 7
Contributors 9
2 The Actin-Cytoskeleton and Glial Cell Transformation: Dissecting the Molecular Dynamics of Tumorigenesis[Kenneth A. Giuliono] 35
3 The Fibrinolytic System in Human Brain Tumors: Association with Pathophysiological Conditions of Malignant Brain Tumors[Jasti S.Rao, Masaaki Yamamoto, Auoy K. Bindal, Weiming Shi, Shu Zhi Wu, and Raymond Sawaya] 49
4 Fibroblast Growth Factors in Astrocytomas[Richard S. Morrison, Shoko M.Yamada, and Yahua Yu] 69
5 Angiogenesis Inhibition in the Treatment of CNS Tumors[Allen K. Sills, Jr., Eric P. Sipos, John Laterra, and Henry Brem] 81
6 Protein Kinase C Inhibition, a Potential Therapeutic Strategy for Malignant Glial Tumors: A Summary of Preliminary Results and Future Directions[Ian F. Pollack, Pollack, Stephanie Kawecki, and John S. Lazo] 97
Section II Diagnosis 113
7 Imaging Update[Charles A. Jungreis and Carolyn Cidis Meltzer] 115
8 Molecular Neuropathology in Brain Tumor Diagnosis[Paul E. Mckeever] 139
Section III Therapy 179
9 Corticl Mapping in Tumor Resection[George A. Ojemann] 183
10 Ultrasonic Characteristics of Brain Tumors[George J. Dohrmann and Jonathan M. Rubin] 191
11 Intraoperative Neurophysiological Monitoring During Removal of Brain Tumors[Aage R. Moller] 207
12 Stereotactic Radiosurgery for Benign and Malignant Diseases of the Brain[Zbigniew Petrovich, Gary Luxton, Silvia C. Formenti, Chi-Shing Zee, Chang Yu, Gabor Jozsef, and Michael L. J. Apuzzo] 219
13 Surgery for Spinal Metastases[William C. Welch] 259
14 Radiobiology Update[James D. Kolker and Ralph R. Weichselbaum] 283
15 Radiotherapy Management of Brain Tumors[Khaled M. Alekhteyar and Eli Glatstein] 307
16 Chemotherapy of Brain Tumors[M. Kelly Nicholas and Michael D. Prados] 331
17 Chemotherapy and Pediatric Brain Tumors[Joāo Siffert and Jeffrey C. Allen] 363
18 Chemosensitivity Testing Human Malignant Brain Tumors[John L. Darling. G. M. Lewandowicx, and David G. T. Thomas] 413
19 The Treatment of Barin Tumors with Drug-Impregnated Biodegradable Polymers[Phillip B. Storm and Henry Berm] 435
20 Immunobiology fo Malignant Gliomas[M. Tada and Nicolas de Tribolet] 447
21 Interleukin-2,the Cerebrovasculature, and the Treatment of Malignant Glioma[Randall E. Merechant, Mary D. Ellison, and Carol A. Kruse] 469
22 Cellular Therapy of Brain Tumors: Clinical Trials[Carol A. Kruse] 487
23 Targeted Toxin Therapy[Walter A. Hall] 505
24 Herpes Simplex Gene Therapy Vectors for the Treatment of Cancer[Thomas Oligino, David Krisky, Peggy Marconi, David J. Fink, and Joseph C. Glorioso] 517
25 Genetic Approaches for the Therapy of Malignant Brain Tumors[Edward H. Oldfield and Zvi Ram] 541
Index 553