Introduction:Purpose and Scope of the Symposium＆BERNARD D．DAVIS 1
Part Ⅰ:The Origin of Enzymes＆Chairman:Bernard D．Davis 5
1．Remarks on the Mechanism of Enzyme Induction＆JACQUES MONOD 7
2．Enzymes in Cellular Differentiation＆BORIS EPHRUSSI 29
Added Comment＆MELVIN COHN 41
General Discussion＆BERNARD D．DAVIS,JACQUES MONOD,SOL SPIEGELMAN,CARL C．LINDEGREN,BORIS EPHRUSSI 46
3．Nucleic Acids and Enzyme Synthesis＆ERNEST F．GALE 49
4．On the Nature of the Enzyme-Forming System＆SOL SPIEGELMAN 67
Added Comment＆SIDNEY F．VELICK 90
General Discussion＆BERNARD D．DAVIS,SOL SPIEGELMAN,JACQUES MONOD,BORIS ROTMAN,ERNEST F．GALE,ARTHUR B．PARDEE,EDWARD L．TATUM,A．D．HERSHEY,MELVIN COHN,MAHLON B．HOAGLAND,ALVIN MARKOVITZ 93
Part Ⅱ:The Status of the Gene-Enzyme Relationship＆Chairman:Edward L．Tatum 105
Chairman＇s Comments＆EDWARD L．TATUM 107
5．Genetic Structure and Function in Bacteriophage T2＆A．D．HERSHEY 109
6．The Genetic Organization of the Deoxyribonucleate Units Functioning in Bacterial Transformations＆ROLLIN D．HOTCHKISS 119
Added comment＆M．DEMEREC 131
General Discussion＆NORMAN H．HOROWITZ,JACQUES MONOD,EDWARD L．TATUM,BERNARD D．DAVIS,CHARLES YANOFSKY,M．DEMEREC,A．D．HERSHEY,SOL SPIEGELMAN 134
7．The Role of the Genes in the Synthesis of Enzymes＆NORMAN H．HOROWITZ AND MARGUERITE FLING 139
8．Gene Interactions in Enzyme Synthesis＆CHARLES YANOFSKY 147
Comments on Gene-Enzyme Relationship＆JOSHUA LEDERBERG 161
General Discussion＆STUART MUDD,SOL SPIEGELMAN,RUTH SAGER,NORMAN H．HOROWITZ,EDWARD L．TATUM,ROBERT J．RUTMAN,HARRY EAGLE,CYRUS LEVINTHAL,NATHAN O．KAPLAN,JACQUES MONOD 170
Evening Lecture 175
The Future of Enzyme Research＆LINUS PAULING 177
Part Ⅲ:Enzymes and Cell Structure＆Chairman:George H．Hogeboom 183
9．Electron Microscopy of Mitochondria and Other Cytoplasmic Structures＆GEORGE E．PALADE 185
10．Physiology of Mitochondria＆ALBERT L．LEHNINGER 217
11．Sedimentation and Biochemical Characteristics of Cytoplasmic Particles＆EDWARD L．KUFF AND GEORGE H．HOGEBOOM 235
Added Comment＆VAN R．POTTER 252
General Discussion＆FRITZ LIPMANN,ALBERT L．LEHNINGER,DANIEL I．ARNON,HERRICK BALTSCHEFFSKY,BRITTON CHANCE,GEORGE E．PALADE 257
12．Nuclear Products and Nuclear Reproduction＆DANIEL MAZIA 261
13．Localization of Photosynthesis in Chloroplasts＆DANIEL I．ARNON 279
General Discussion＆CYRUS LEVINTHAL,DANIEL MAZIA,SEVERO OCHOA,DANIEL I．ARNON,NATHAN O．KAPLAN,VERNON CHELDELIN,GEORGE E．PALADE,HENRY A．LARDY,ALBERT L．LEHNINGER,DAVID E．GREEN,FRITZ LIPMANN 306
Part Ⅳ:Enzymatic Basis of Some Physiological Functions＆Chairman:A．Baird Hastings 315
14．The Actomyosin System and its Participation in Organized Enzyme Reactions＆W．F．H．M．MOMMAERTS 317
15．Is Energy Transferred from ATP to Myosin at the Moment that ATP is Split?＆MANUEL F．MORALES 325
16．Enzymatic Aspects of Excretory Mechanisms＆JOHN V．TAGGART 337
Added Comment＆GILBERT H．MUDGE 347
General Discussion＆A．BAIRD HASTINGS,JOHN GERGELY,MANUEL F．MORALES,W．F．H．M．MOMMAERTS,SIDNEY BERNHARD 349
17．The Biochemistry of Visual Excitation＆GEORGE WALD 355
18．The Enzymatic Basis of Light Emission＆WILLIAM D．MCELROY AND ARDA GREEN 369
Added Comment＆BERNARD L．STREHLER 381
General Discussion＆GEORGE WALD,MANUEL F．MORALES,WILLIAM D．MCELROY,W．F．H．M．MOMMAERTS,DANIEL I．ARNON,BERNARD L．STREHLER,J．J．WOLKEN 383
Evening Lecture 391
Mechano-chemical Coupling in Muscle＆ALBERT SZENT-GYORGYI 393
Part Ⅴ．Cellular Energy Sources＆Chairman:Fritz Lipmann 399
19．Components of the Cytochrome System＆ELMER H．STOTZ,MARTIN MORRISON,AND GUIDO MARINETTI 401
20．Succinic Dehydrogenase＆THOMAS P．SINGER,EDNA B．KEARNEY,AND VINCENT MASSEY 417
Added Comment＆ERIC G．BALL 433
General Discussion＆VAN R．POTTER,THOMAS P．SINGER,FRITZ LIPMANN,RICHARD J．WINZLER,HAROLD A．NEUFELD 440
Chairman＇s Comments＆FRITZ LIPMANN 444
21．Interaction of Adenosinediphosphate with the Respiratory Chain＆BRITTON CHANCE 447
22．Structural and Enzymatic Pattern of the Electron Transfer System＆DAVID E．GREEN 465
23．Hematin Compounds in the Metabolism of Photosynthetic Tissues＆MARTIN D．KAMEN 483
General Discussion＆W．F．H．M．MOMMAERTS,BRITTON CHANCE,DANIEL I．ARNON,FRITZ LIPMANN,DAVID E．GREEN,GEORGE E．PALADE,J．A．BASSHAM,MANUEL F．MORALES,ALVIN NASON,RALPH W．MCKEE,RONALD ESTABROOK,EDWARD L．TATUM 498
Part Ⅵ:Regulation of Enzyme activity＆Chairman:Severo Ochoa 505
Chairman＇s Comments 507
24．Relations between Enzymes and Permeability (Membrane Transport) in Bacteria＆BERNARD D．DAVIS 509
25．Action of Drugs on Enzyme Systems＆J．H．QUASTEL 523
Added Comment＆EARL W．SUTHERLAND,JR． 536
General Discussion＆SEVERO OCHOA,BERNARD D．DAVIS,CYRUS LEVINTHAL,JACQUES MONOD,STUART MUDD,OLOV LINDBERG,ARTHUR B．PARDEE 541
26．Interference with Nucleic Acid Metabolism＆ARNOLD D．WELCH 547
27．Regulation of Enzyme Activity in Muscle During Work＆CARL F．CORI 573
Added Comment＆HENRY A．LARDY AND R．E．PARKS,JR． 584
Chairman＇s Comments＆SEVERO OCHOA,ROBIN C．BUERKI 588
Author Index 589
Subject Index 604