第一部分 奋斗历程 1
侯凡凡院士简历 3
第二部分 学术贡献 7
一、侯凡凡院士的学术成就与学术思想 9
二、侯凡凡院士的主要学术论文 13
（一）临床研究论文 13
Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency 13
Renoprotection of Optimal Antiproteinuric Doses （ROAD） Study：A Randomized Controlled Study of Benazepril and Losartan in Chronic Renal Insufficiency 23
Urinary Angiotensinogen Level Predicts Acute Kidney Injury in Acute Decompensated Heart Failure：a Prospective，Two-Stage Study 34
Enhanced Expression of Receptor for Advanced Glycation End Products in Chronic Kidney Disease 49
Receptor for Advanced Glycation End Products on Human Synovial Fibroblasts：Role in the Pathogenesis of Dialysis-Related Amyloidosis 58
Accumulation of Tissue Advanced Glycation End Products Correlated with Glucose Exposure Dose and Associated with Cardiovascular Morbidity in Patients on Peritoneal Dialysis 70
Renal Expression of Advanced Oxidative Protein Products Predicts Progression of Renal Fibrosis in Patients with IgA Nephropathy 80
Metabolic Syndrome， but Not Insulin Resistance， is Associated with an Increased Risk of Renal Function Decline 93
High Level of Proteinuria During Treatment With Renin—Angiotensin Inhibitors Is A Strong Predictor of Renal Outcome in Nondiabetic Kidney Disease 102
Successful Treatment of Massive Ascites with Intraperitoneal Administration of a Steroid in a Case of Systemic Lupus Erythematosus 112
Increased Plasma Advanced Oxidation Protein Products is an Early Marker of Endothelial Dysfunction in Type 2 Diabetes Patients Without Albuminuria 115
（二）基础研究论文 124
Kindlin-2 Mediates Activation of TGF-β/Smad Signaling and Renal Fibrosis 124
A Salt-Induced Reno-Cerebral Reflex Activates RAS and Promotes CKD Progression 139
GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation 166
Advanced Oxidation Protein Products Accelerate Renal Fibrosis in A Remnant Kidney Model 184
Aminoguanidine Inhibits Advanced Glycation End Products Formation on β2-Microglobulin 195
The Receptor of Advanced Glycation End Products Plays A Central Role In Advanced Oxidation Protein Products Induced Podocyte Apoptosis 202
Accumulation of Advanced Oxidation Protein Products Induces Podocyte Apoptosis and Deletion Through NADPH-Dependent Mechanisms 215
Restricted Intake of Dietary Advanced Glycation End Products Retards Renal Progression in the Remnant Kidney Model 231
β2-Microglobulin Modified with Advanced Glycation End Products Delays Monocyte Apoptosis 244
β2-Microglobulin Modified with Advanced Glycation End Products Modulates Collagen Synthesis by Human Fibroblasts 258
Interaction Between β2-Microglobulin and Advanced Glycation End Products in the Development of Dialysis Related- Amyloidosis 268
Advanced Oxidation Protein Products Activate Intrarenal Renin-Angiotensm System Via a CD36-Mediated， Redox-Dependent Pathway 275
Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway 294
Picrorhiza Scrophulariiflora Improves Accelerated Atherosclerosis Through Inhibition of Redox-Sensitive Inflammation 309
Lingzhiols，Unprecedented Rotary Door Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum 319
Acortatarins A and B， Two Novel Antioxidative Spiroalkaloids with A Naturally Unusual Morpholine Motif from Acorus Tatarinowii 324
Advanced Oxidation Protein Products Accelerate Atherosclerosis Through Promoting Oxidative Stress and Inflammation 329
AGE-LDL Activates Toll Like Receptor 4 Pathway and Promotes Inflammatory Cytokines Production in Renal Tubular Epithelial Cells 337
Salt-Induced Changes in Cardiac Phosphoproteome in a Rat Model of Chronic Renal Failure 350
Albumin Overload Activates Intrarenal Renin-Angiotensin System Through Protein Kinase C and NADPH Oxidasedependent Pathway 362
Bioactive Compounds from the Aerial Parts of Brachystemma Calycinum and Structural Revision of An Octacyclopeptide 375
Detection of Advanced Oxidation Protein Products in Patients with Chronic Kidney Disease by A Novel Monoclonal Antibody 386
Vascular Insulin Resistance Related to Endoplasmic Reticulum Stress in Aortas from a Rat Model of Chronic Kidney Disease 396
Advanced Oxidation Protein Products Inhibit Differentiation and Activate Inflammation in 3T3-Ll Preadipocytes 411
Advanced Oxidation Protein Products Induce Inflammatory Response and Insulin Resistance in Cultured Adipocytes Via Induction of Endoplasmic Reticulum Stress 422
Asymmetrical Dimethylarginine Triggers Lipolysis and Inflammatory Response Via Induction of Endoplasmic Reticulum Stress in Cultured Adipocytes 435
Advanced Oxidation Protein Products Induce Mesangial Cell Perturbation Through PKC-Dependent Activation of NADPH Oxidase 447
Ethanol Extraction of Picrorhiza Scrophulariiflora Prevents Renal Injury in Experimental Diabetes Via Anti-Inflammation Action 460
Advanced Oxidation Protein Products Promote Inflammation in Diabetic Kidney through Activation of Renal Nicotinamide Adenine Dinucleotide Phosphate Oxidase 470
1，25-Dihydroxyvitamin D Improved the Free Fatty-Acid-Induced Insulin Resistance in Cultured C2C12 Cells 483
Phenotypic and Functional Characteristics of Macrophage-Like Cells Differentiated in Pro-Inflammatory Cytokine-Containing Cultures 490
三、侯凡凡院士学术年表 500
侯凡凡院士在SCI收录期刊发表的社论和特邀述评 500
侯凡凡院士在SCI收录期刊发表的共同作者论著 501
侯凡凡院士承担的主要科研项目目录 503
侯凡凡院士主要国际会议演讲目录 504
第三部分 治学之道 507
努力作科学而不是努力作文章 509
凡凡女人心，不凡医者仁心路 511
漫漫行医路 浓浓鱼水情 514
循证医学可显著提高医疗卫生活动效率 519
第四部分 大师风范 521
医者仁心 师者爱心 学者恒心——记侯凡凡院士 523
第五部分 社会影响 527
不凡医者仁心路 529
最是那昂首的妩媚 530
走近女院士——侯凡凡 535
与病人交心才能确保治疗效果 537
我不认为我是大器晚成 539
既然当了医生，就得当位好医生 542
南方医院侯凡凡院士入选“全国医患和谐典型人物” 544
当医生就要把心交给患者 545
南方医院《关于开展向侯凡凡同志学习的决定》 548
病房没有关门，我就不能走远 550
技高为师 身正为范 552
第六部分 人生风采 555
成长经历 557
医疗科研 559
国际交流 564
历史时刻 567
幸福生活 569