第一部分 奋斗历程 1
用生命和激情在对话基因的路上追逐阳光——记中国工程院院士 第二军医大学国家肝癌科学中心主任王红阳 3
第二部分 学术贡献 27
一、王红阳院士的学术成就和学术思想 29
二、王红阳院士的主要学术论文 32
Characterization of PCP-2,a Novel Receptor Protein Tyrosine Phosphatase of the MAM Domain Family 32
Characterization of the PEST Family Protein Tyrosine Phosphatase BDP1 42
A Family of Proteins that Inhibit Signalling Through Tyrosine Kinase Receptors 48
Cloning and Expression of MXR7 Gene in Human HCC Tissue 56
肿瘤相关信号转导研究的现状与未来 61
Molecular Cloning and Characterization of a Novel Gene Which is Highly Expressed in Hepatocellular Carcinoma 67
Negative Regulation of Hepatocellular Carcinoma Cell Growth by Signal Regulatory Protein α1 80
Use of Adenovirus-Delivered siRNA to Target Oncoprotein p28GANKin Hepatocellular Carcinoma 94
LPS-induced Down-regulation of Signal Regulatory Protein α Contributes to Innate Immune Activation in Macrophages 109
The Role of MicroRNA Expression Pattern in Human Intrahepatic Cholangiocarcinoma 124
p28GANKInhibits Endoplasmic Reticulum Stress-induced Cell Death Via Enhancement of the Endoplasmic Reticulum Adaptive Capacity 138
Abrogation of Local Cancer Recurrence after Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine 153
Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis in Rodents 164
Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma 177
p28GANK Overexpression Accelerates Hepatocellular Carcinoma Invasiveness and Metastasis via Phosphoinositol 3-Kinase/AKT/Hypoxia-Inducible Factor-1 α Pathways 190
The Protective Role of Hydrogen-rich Saline in Experimental Liver Injury in Mice 203
Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis 215
Nuclear Factor High-Mobility Group Boxl Mediating the Activation of Toll-Like Receptor 4 Signaling in Hepatocytes in the Early Stage of Nonalcoholic Fatty Liver Disease in Mice 228
Gankyrin-Mediated Dedifferentiation Facilitates the Tumorigenicity of Rat Hepatocytes and Hepatoma Cells 239
Hepatitis B Virus X(HBx)Induces Tumorigenicity of Hepatic Progenitor Cells in 3,5-Diethoxycarbonyl-1,4-dihydrocollidine-Treated HBx Transgenic Mice 253
Metabolomics Study of Stepwise Hepatocarcinogenesis from the Model Rats to Patients:Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis 267
p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis 280
Profound Impact of Gut Homeostasis on Chemically-induced Pro-tumorigenic Inflammation and Hepatocarcinogenesis in Rats 305
OV6+ Tumor-initiating Cells Contribute to Tumor Progression and Invasion in Human Hepatocellular Carcinoma 316
The Tyrosine Kinase c-Met Contributes to the Pro-tumorigenic Function of the p38 Kinase in Human Bile Duct Cholangiocarcinoma Cells＊？ 326
Hepatic Transforming Growth Factor Beta Gives Rise to Tumor-Initiating Cells and Promotes Liver Cancer Development 340
miR-20a Triggers Metastasis of Gallbladder Carcinoma 354
Signal Regulatory Protein α Is Associated with Tumor-Polarized Macrophages Phenotype Switch and Plays a Pivotal Role in Tumor Progression 366
Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma 379
Implication of Transcriptional Repression in Compound C-induced Apoptosis in Cancer Cells 391
MUC15 Inhibits Dimerization of EGFR and P13K-AKT Signaling and Is Associated with Aggressive Hepatocellular Carcinomas in Patients 403
Epigenetic Modification of MiR-429 Promotes Liver Tumour-Initiating Cell Properties by Targeting Rb Binding Protein 4 429
三、王红阳院士的主要学术著作 444
细胞信号转导——基本理论与实用技术 444
四、王红阳院士学术年表 470
王红阳院士论文目录 470
王红阳院士专著目录 487
王红阳院士获奖目录 488
第三部分 治学之道 489
真金，一定会发光 491
激发人才的创新潜能 494
探索“冰山”下的“潜流” 495
生命因丰富而精彩 497
我眼中的师姐——红阳 499
在大师身边工作 感受关爱的正能量 502
第四部分 大师风范 503
首设创新团队奖——应大科学时代而生 505
国家科技进步奖揭晓 医卫界40成果上榜 507
上海首获国家科技进步奖创新团队奖 508
俯仰不愧天地 褒贬自有春秋 509
切身感受大师风范 511
我学到的不止这么多 513
人生的灯塔 心中的恩师 514
第五部分 社会影响 517
让生命远离名利与平庸——记中国工程院院士王红阳 519
她有着严师慈母般的情怀——记全国“三八红旗手”标兵王红阳 523
激情 忠诚 仁爱——访第二军医大学东方肝胆外科研究所副所长王红阳 525
王红阳：基因海洋领航人 527
破译生命奥秘的人——记第二军医大学东方肝胆外科医院王红阳教授 529
对科学的热爱使她更美丽——记第二军医大学附属东方肝胆外科医院王红阳教授 532
畅游在人类基因海洋——记我国第一个生物信号传递中心创业者王红阳博士 534
王红阳受聘为国家自然科学基金委医学科学部主任 536
“国家肝癌科学中心”上午在沪开工——远期目标：使我国肝癌发病率下降15％，5年生存率提高10％ 538
曹雪涛、夏照帆、王红阳受聘为“长江学者奖励计划”特聘教授 540
王红阳院士受聘华中科大转化医学研究院院长 541
After Long March,Scientists Create"Chinese NIH" 543
肝癌早期诊断标志物被发现 544
二甲双胍对肝癌有抑制作用——激活蛋白激酶，降低肝癌细胞体内成瘤能力 545
四种与疾病相关新基因被发现——东方肝胆外科医院一项成果获奖 546
抽血5毫升 病情提前知——本市已研制出肝癌检测基因 准确率可达80％以上 547
王红阳：让虚假药品广告从主流媒体上消失 548
第六部分 人生风采 549