第一部分 奋斗历程 1
程京的中国芯——程京院士自传 3
程京院士小传 9
第二部分 学术贡献 11
一、程京院士的学术成就与学术思想 13
二、程京院士的主要学术论文 16
The Extraction and Classification of Dyes from Cotton Fibres Using Different Solvent Systems 16
Glycerol-enhanced Separation of DNA Fragments in Entangled Solution Capillary Electrophoresis 23
Polymerase Chain Reaction Heteroduplex Polymorphism Analysis by Entangled Solution Capillary Electrophoresis 30
Chip PCR.Ⅰ.Surface Passivation of Microfabricated Silicon-glass Chips、for PCR 38
Chip PCR.Ⅱ.Investigation of Different PCR Amplification Systems in Microfabricated Silicon-glass Chips 44
Diagnosis of Duchenne/Becker Muscular Dystrophy and Quantitative Identification of Carrier Status by Use of Entangled Solution Capillary Electrophoresis 52
The Use of Capillary Electrophoresis for Point-mutation Screening 61
Sample Preparation in Microstructured Devices 74
Integrated Cell Isolation and Polymerase Chain Reaction Analysis Using Silicon Microfiltrer Chambers 85
Degenerate Oligonucleotide Primed-polymerase Chain Reaction and Capillary Electrophoretic Analysis of Human DNA on Microchip-based Devices 91
Isolation of Cultured Cervical Carcinoma Cells Mixed with Peripheral Blood Cells on a Bioelectronic Chip 98
Preparation and Hybridization Analysis of DNA/RNA from E.coli on Microfabricated Bioelectronic Chips 105
Response of Gene Expression in Saccharomyces cerevisiae to Amphoteriein B and Nystatin Measured by Microarrays 115
Single Nucleotide Polymorphism Discrimination Assisted by Improved Base Stacking Hybridization Using Oligonucleotide Microarrays 127
Preparation of Steroid Antibodies and Parallel Detection of Multianabolic Steroid Abuse with Conjugated Hapten Microarray 134
Negative Dielectrophoretic Force Assisted Construction of Ordered Neuronal Networks on Cell Positioning Bioelectronic Chips 142
The Design and Application of DNA Chips for Early Detection of SARS-CoV from Clinical Samples 157
Parallel Profiling of Active Transcription Factors Using an Oligonucleotide Array-based Transcription Factor Assay （OATFA） 167
Genomic Analysis of Anti-hepatitis B Virus（HBV） Activity by Small Interfering RNA and Lamivudine in Stable HBV-producing Cells 175
The MicroArray Quality Control （MAQC） Project Shows Inter- and Intraplatform Reproducibility of Gene Expression Measurements 191
Protein Chips for High-throughput Doping Screening in Athletes 207
Multiplex Asymmetric PCR-based Oligonucleotide Microarray for Detection of Drug Resistance Genes Containing Single Mutations in Enterobacteriaceae 211
Use of a DNA Microarray for Simultaneous Detection of Antibiotic Resistance Genes among Staphylococcal Clinical Isolates 222
Construction of a Multiplex Allele-specific PCR-based Universal Array （ASPUA） and its Application to Hearing Loss Screening 234
Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma 246
Analysis of the Sensitivity and Frequency Characteristics of Coplanar Electrical Cell-substrate Impedance Sensors 256
Novel High-throughput Profiling of Human Transcription Factors and its Use for Systematic Pathway Mapping 266
Broad Profiling of DNA-binding Transcription Factor Activities Improves Regulatory Network Construction in Adult Mouse Tissues 281
Quantitative Fluorescence Correction Incorporating Forster Resonance Energy Transfer and its Use for Measurement of Hybridization Efficiency on Microarrays 295
Real-time，Label-free Monitoring of the Cell Cycle with a Cellular Impedance Sensing Chip 303
Integration of Sperm Motility and Chemotaxis Screening with a Microchannel-based Device 312
The MicroArray Quality Control（MAQC）Ⅱ Study of Common Practices for the Development and Validation of Microarray-based Predictive Models 321
Integration of Single Oocyte Trapping，in vitro Fertilization and Embryo Culture in a Microwell-structured Microfluidic Device 343
MicroRNAs-372/373 Promote the Expression of Hepatitis B Virus Through the Targeting of Nuclear Factor I/B 352
Validation of a Mobile Phone-assisted Microarray Decoding Platform for Signal-enhanced Mutation Detection 366
Biochips for Translational Medicine 375
A Microfluidic Device with Passive Air-bubble Valves for Real-time Measurement of Dose-dependent Drug Cytotoxicity through Impedance Sensing 377
MicroRNA-133b is a Key Promoter of Cervical Carcinoma Development through the Activation of the ERK and AKT1 Pathways 383
Use of Cellular Electrical Impedance Sensing to Assess in vitro Cytotoxicity of Anticancer Drugs in a Human Kidney Cell Nephrotoxicity Model 395
Construction of a Novel Oligonucleotide Array-based Transcription Factor Interaction Assay Platform and its Uses for Profiling STAT1 Cofactors in Mouse Fibroblast Cells 405
A Rapid Automatic Processing Platform for Bead Label-assisted Microarray Analysis：Application for Genetic Hearing-loss Mutation Detection 415
三、程京院士的主要学术著作 425
Capillary Electrophoresis of Nucleic Acids 425
Biochip Technology 433
生物芯片：生命信息CPU 435
生物芯片技术 443
四、程京院士学术年表 445
程京院士论文目录 445
程京院士著作目录 461
程京院士国际和国内发明专利目录 464
科研成果奖目录 488
荣誉奖项目录 490
第三部分 大师风范 493
读书期间的回顾和感言 495
同一屋檐下 496
学术的导师，人生的楷模 499
我眼中的程老师 502
成长的蜕变 505
记忆中程老师的点点滴滴 506
念奴娇·毕业感言 508
“严谨细致”成就精彩人生——观《程京：小芯片书写大人生》有感 509
一种全新基因突变检测芯片的研究及在耳聋筛查中的应用 511
人源转录因子芯片的构建及在信号通路系统筑图中的应用 512
研制并利用神经芯片研究神经网络活动中的时空模式 513
小鼠组织特异性转录调控网络的构建 514
细胞内的miRNA参与调控乙型肝炎病毒表达的研究 515
构建通用磁珠解码芯片平台并应用于遗传性耳聋检测 516
MiR-133b在宫颈癌发生与发展中的作用研究 517
精子健康评价与体外受精芯片系统的开发与应用 518
用于精子筛选及体外受精的微流控芯片的构建及应用 519
用于药物开发与评价的细胞芯片平台的构建 520
用于精子健康评价与筛选的微流控芯片系统的构建与应用 521
第四部分 社会影响 523
写在生物芯片上的人生——记北京博奥生物芯片公司总裁程京博士 525
美国《时代》：中国能成为创新中心吗？ 530
生物科技的“中国芯” 532
程京：活跃的中国生物芯片领域 535
程京：中国生物芯片探路者 539
让生物芯片见证中国“加速度” 543
程京“小”芯片 书写“大”人生 551
人类健康的侦察兵 557
管理创新要跟上 559
程京：“芯”人问政 560
什么拖了“中国创造”后腿 563
程京：被“续挂”的党外代表人士 566
健康产业发展的历史与未来——访中国工程院院士程京 568
程京：用心缔造“中国芯” 572
中国工程院院士程京：中国梦根植于健康梦 577
部分新闻宣传报道列表 579
第五部分 人生风采 585
成长历程 588
海外深造 589
归国创业 591
教书育人 593
学术交流 595
实至名归 598
社会责任 600