UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY 1
1 History and Scope of Toxicology&Michael A.Gallo 3
2 Principles of Toxicology&David L.Eaton and Curtis D.Klaassen 11
3 Mechanisms of Toxicity&Zoltán Gregus and Curtis D.Klaassen 35
4 Risk Assessment&Elaine M.Faustman and Gilbert S.Omenn 83
UNIT 2 DISPOSITION OF TOXICANTS 105
5 Absorption,Distribution,and Excretion of Toxicants&Karl K.Rozman and Curtis D.Klaassen 107
6 Biotransformation of Xenobiotics&Andrew Parkinson 133
7 Toxicokinetics&Michele A.Medinsky and John L.Valentine 225
UNIT 3 NON-ORGAN-DIRECTED TOXICITY 239
8 Chemical Carcinogenesis&Henry C.Pitot Ⅲ and Yvonne P.Dragan 241
9 Genetic Toxicology&R.Julian Preston and George R.Hoffmann 321
10 Developmental Toxicology&John M.Rogers and Robert J.Kavlock 351
UNIT 4 TARGET ORGAN TOXICITY 387
11 Toxic Responses of the Blood&John C.Bloom and John T.Brandt 389
12 Toxic Responses of the Immune System&Leigh Ann Burns-Naas,B.Jean Meade,and Albert E.Munson 419
13 Toxic Responses of the Liver&Mary Treinen-Moslen 471
14 Toxic Responses of the Kidney&Rick G.Schnellmann 491
15 Toxic Responses of the Respiratory System&Hanspeter R.Witschi and Jerold A.Last 515
16 Toxic Responses of the Nervous System&Douglas C.Anthony,Thomas J.Montine,William M.Valentine and Doyle G.Graham 535
17 Toxic Responses of the Ocular and Visual System&Donald A.Fox and William K.Boyes 565
18 Toxic Responses of the Heart and Vascular Systems&Kenneth S.Ramos,Russell B.Melchert,Enrique Chacon and Daniel Acosta,Jr 597
19 Toxic Responses of the Skin&David E.Cohen and Robert H.Rice 653
20 Toxic Responses of the Reproductive System&Michael J.Thomas and John A.Thomas 673
21 Toxic Responses of the Endocrine System&Charles C.Capen 711
UNIT 5 TOXIC AGENTS 761
22 Toxic Effects of Pesticides&Donald J.Ecobichon 763
23 Toxic Effects of Metals&Robert A.Goyer and Thomas W.Clarkson 811
24 Toxic Effects of Solvents and Vapors&James V.Brucknerand D.Alan Warren 869
25 Toxic Effects of Radiation and Radioactive Materials&Naomi H.Harley 917
26 Toxic Effects of Terrestrial Animal Venoms and Poisons&Findlay E.Russell 945
27 Toxic Effects of Plants&Stata Norton 965
UNIT 6 ENVIRONMENTAL TOXICOLOGY 977
28 Air Pollution&Daniel L.Costa 979
29 Ecotoxicology&Ronald J.Kendall,Todd A.Anderson,Robert J.Baker,Catherine M.Bens,James A.Carr,Louis A.Chiodo,George P.Cobb Ⅲ,Richard L.Dickerson,Kenneth R.Dixon,Lynn T.Frame,Michael J.Hooper,Clyde F.Martin,Scott T.McMurry,Reynaldo Patino,Ernest E.Smith,Christopher W.Theodorakis 1013
UNIT 7 APPLICATIONS OF TOXICOLOGY 1047
30 Food Toxicology&Frank N.Kotsonis,George A.Burdock,and W.Gary Flamm 1049
31 Analytic/Forensic Toxicology&Alphonse Poklis 1089
32 Clinical Toxicology&Louis R.Cantilena,Jr 1109
33 Occupational Toxicology&Peter S.Thorne 1123
34 Regulatory Toxicology&Richard A.Merrill 1141
Appendix:Recommended Limits for Occupational Exposure to Chemicals&John Doull 1155
Index 1177