Ⅰ.Structure and Genetics of Immune-Globulins 13
Genetically Determined Structures of Immune-Globulins&Morten Harboe and C.Kirk Osterland 13
The γ-Globulin Groups in Man-Their Structural Basis and Biologic Significance&E.C.Franklin,H.Fudenberg,L.Martensson,M,Meltzer and D.R.Stanworth 25
Immunochemical Studies on Antigenic Structure of Human γ-and β2-Globulins&P.Burtin 38
Two Types of Molecules(Ⅰ and Ⅱ)present in the four Major γ-Globulin Groups&John L.Fahey 50
Unresolved Problems in the Analysis of the Structure of Antibodies&Gerald M.Edelman 57
Discussion on Structure and Genetics of Immune-Globulins 68
Ⅱ.Antibody Formation 79
Antibody Formation in Vitro&M.Fishman and F.L.Adler 79
The Origin of Antibody-Forming Cells&J.L.Gowans and D.D.McGregor 89
Cytokinetics of Antibody Response&T.Makinodan and J.F.Albright 99
The Nature of RNA Synthesis in Immune Induction&G.J.V.Nossal and Judith Mitchell 113
Antibody Formation to Bacteriophage ?X 174&Jonathan W.Uhr and Martin S.Finkelstein 127
Discussion on Antibody Formation 136
Ⅲ.Influence of Various Factors on Antibody Response 148
Critical Factors Governing the Response Pattern:Immunity versus Tolerance&Milan Hasek 148
X-Ray Enhancement of Antibody Formation&Frank J.Dixon and Patricia J.McConahey 158
Autoimmunity and Termination of Acquired Immunological Tolerance&William O.Weigh 167
Studies on the Role of the Thymus in Developmental Biology,with a Consideration of the Association of Thymus Abnormalities and Clinical Disease&Robert A.Good,Carlos Martinez,Agustin P.Dalmasso,Ben W.Papermaster and Ann E.Gabrielsen 177
Discussion on Influence of Various Factors on Antibody Response 201
Ⅳ.Mechanisms of Immunogenic Kidney Diseases 208
Specific Nephrotoxic Nephritis:Old Facts and Present Concepts&B.C.Seegal,K.C.Hsu and G.A.Andres 208
Demonstration of and Evidence for the Lymphocyte Bound Nature of a Secondary Nephritis Producing Factor in Nephrotoxic Glomerulonephritis in Rats&E.F.Pfeiffer 220
Experimental Autoimmune Renal Disease in Rats&Walter Heymann,E.P.Kmetec,S.G.F.Wilson,J.L.P.Hunter,Donald B.Hackel and Francis Cuppage 240
Glomerulonephritis Induced in Sheep and Monkeys by Injections of Heterologous Glomerular Basement Membrane and Freund's Adjuvant&Raymond W.Steblay 252
Pathogenesis of Ultrastructural Glomerular Changes induced by Immunologic Means&Joseph D.Feldman 263
Antigenic Components of Hemolytic Streptococci&Richard M.Krause 282
Discussion on Mechanisms of Immunogenic Kidney Diseases 290
Ⅴ.Mechanisms of Blood Cell Damage Produced by Immunological Reactions 300
Mechanisms of Immune Injury in Mammalian Cell Systems&Burton Goldberg 300
Mechanism of Elimination of Sensitized Rat Erythrocytes and E.Coli from the Circulation of Mice&P.A.Miescher,H.L.Spiegelberg and B.Benacerraf 311
Observations on the Immunochemical Nature of Red Cell Autosensitization&J.P.Leddy,R.W.Hill,S.N.Swisher and J.H.Vaughan 318
Identification of Complement Antigens Coating Red Cells in Acquired Hemolytic Anemia&H.J.Muller-Eberhard 332
Mechanism of Blood Cell Damage by Adsorption of Antigen-Antibody Complexes&N.Raphael Shulman 338
Reticuloendothelial Proliferation Stimulated by Injured,Autologous Red Cells&James H.Jandl,Harry S.Jacob and Richard A.MacDonald 353
Discussion on Mechanisms of Blood Cell Damage Produced by Immunological Reactions 369
Index 387