The Pharmacological Basis of Therapeutics Second EditionPDF电子书下载

SECTION Ⅰ．INTRODUCTION 1

1．General Principles 1

SECTION Ⅱ．CENTRAL NERVOUS SYSTEM DEPRESSANTS 21

2．History and Theories of General Anesthesia 21

3．Stages of General Anesthesia 28

4．Preanesthetic Medication，Technics of Anesthesia，Anesthetic Accidents，and Properties of Ideal Anesthetics 40

5．General Anesthetics Ⅰ．Ether and Chloroform，Vinyl Ether，Ethyl Chloride，and Tri|chloroethylene 55

6．General Anesthetics (Continued) Ⅱ．Gas Anesthetics：Nitrous Oxide，Ethylene，and Cyclopropane 75

7．Basal Anesthetics 93

8．The Aliphatic Alcohols 98

9．Hypnotics and Sedatives Ⅰ．The Barbiturates 123

10．Hypnotics and Sedatives (Continued) Ⅱ．Bromide，Chloral Hydrate，Paraldehyde，and Miscellaneous Agents (Cannabis，Mescaline) 156

11．Drugs Effective in Convulsive Disorders 178

12．Centrally Acting Skeletal Muscular Relaxants 206

13．Natural and Synthetic Narcotics 216

14．Analgesics and Antipyretics Ⅰ．Salicylates and Congeners；Cinchophen and Congeners；Colchicine 281

15．Analgesics and Antipyretics (Continued) Ⅱ．Acetanilid and Acetophenetidin；Aminopyrine and Antipyrine 311

SECTION Ⅲ．CENTRAL NERVOUS SYSTEM STIMULANTS 324

16．Picrotoxin，Pentylenetetrazol，Nikethamide，Strychnine，and Camphor 325

17．The Xanthines Caffeine，Theophylline，and Theobromine 339

SECTION Ⅳ．LOCAL ANESTHETICS 354

18．Cocaine；Procaine and Other Synthetic Local Anesthetics 354

SECTION Ⅴ．DRUGS ACTING ON AUTONOMIC EFFECTOR CELLS 389

19．Anatomical，Physiological，and General Pharmacological Considerations 389

20．Drugs Stimulating Structures Innervated by Cholinergie Nerves (Parasympathomimetic Drugs) Ⅰ．Choline Esters 422

21．Drugs Stimulating Structures Innervated by Cholinergic Nerves (Parasympathomimetic Drugs) (Continued) Ⅱ．Cholinesterase Inhibitors and Anti-Curare Agents：Physostigmine，Neostigmine，Diisopropylfluorophosphate，Edrophonium，and Their Congeners 444

22．Drugs Stimulating Structures Innervated by Cholinergic Nerves (Parasympathomimetic Drugs) (Continued) Ⅲ．Pilocarpine，Arecoline，and Muscarine 470

23．Drugs Stimulating Structures Innervated by Adrenergic Nerves (Sympathomimetic Drugs) Ⅰ．Epinephrine and Levarterenol 476

24．Drugs Stimulating Structures Innervated by Adrenergic Nerves (Sympathomimetic Drugs) (Continued) Ⅱ．Ephedrine，Amphetamine，and Other Sympathomimetic Drugs 505

25．Autonomic Blocking Agents Ⅰ．Drugs Inhibiting Structures Innervated by Postganglionic Cholinergic Nerves 541

26．Autonomic Blocking Agents (Continued) Ⅱ．Drugs Inhibiting Structures Innervated by Adrenergic Nerves：Adrenergic Blocking Agents 570

27．Autonomic Blocking Agents (Continued) Ⅲ．Drugs Inhibiting Skeletal Muscles and Autonomic Ganglia 596

SECTION Ⅵ．HISTAMINE AND ITS ANTAGONISTS 644

28．Histamine and Antihistaminic Agents 644

SECTION Ⅶ．CARDIOVASCULAR DRUGS 668

29．Digitalis and Allied Cardinc Glycosides 668

30．Antiarrhythmic and Antifibrillatory Agents Quinidine and Procaine Amide 711

31．Vasodilator and Antihypertensive Agents Nitrites，Thiocyanate，Veratrum Alkaloids，Rauwolfia，Hydralazine，and Khellin 730

SECTION Ⅷ．WATER，SALTS，AND INOS 764

32．Agents Affecting Volume and Composition of Body Fluids 764

33．Cations：Potassium，Calcium，Magnesium，Barium，and Ammonium 795

34．Anions：Phosphate，Iodide，Fluoride，and Other Anions 835

SECTION Ⅸ．DRUGS AFFECTING RENAL FUNCTION AND ELECTROLYTE METABOLISM 840

35．Diuretics and Other Agents Employed in the Mobilization of Edema Fluid 840

36．Antidiuretics 869

37．Inhibitors of Renal Tubular Transport of Organic Compounds 880

SECTION Ⅹ．DRUGS AFFECTING UTERINE MOTILITY 886

38．Oxytocics Ergot，Ergot Alkaloids，and Posterior Pituitary 886

SECTION Ⅺ．GASES AND VAPORS 905

39．The Therapeutic Gases Oxygen，Carbon Dioxide，and Helium 905

40．Noxious Gases and Vapors Carbon Monoxide，Hydrocyanic Acid，and Miscellaneous Agents 926

SECTION Ⅻ．HEAVY METALS AND HEAVY-METAL ANTAGONISTS 939

41．Heavy-Metal Antagonists 939

42．Arsenicals 948

43．Mercury，Antimony，Gold，and Miscellaneous Metals 970

44．Lead 1002

SECTION ⅩⅢ．LOCALLY ACTING DRUGS 1017

45．Demulcents，Emollients，Protectives，Adsorbents，Hemostatics，Irritants，Astringents，and Certain Enzymes 1017

46．Gastric Antacids and Digestants 1029

47．Cathartics 1049

48．Emetics，Antiemetics，and Expectorants 1064

SECTION ⅩⅣ．ANTISEPTICS，DISINFECTANTS，AND DRUGS USED IN THE CHEMOTHERAPY OF INFECTIOUS DISEASES 1074

49．Antiseptics，Germicides，Fungicides，Virucides，and Ectoparasiticides 1075

50．Drugs Used in the Chemotherapy of Helminthiasis 1133

51．Drugs Used in the Chemotherapy of Malaria Quinacrine，Chloroquine，Chloroguanide，Pyrimethamine，Pamaquine，Primaquine，and Quinine 1161

52．Drugs Used in the Chemotherapy of Amebiasis Emetine，Halogenated Oxyquinolines，Organic Arsenicals，Chloroquine，and Fumagillin 1208

53．Miscellaneous Drugs Used in the Teatment of Protozoal Infections Diamidines and Suramin 1228

54．Penicillin Therapy of Syphilis 1233

55．Drugs Used in the Chemothernapy of Tuberculosis and Leprosy 1250

56．Sulfonamides 1276

57．Antibiotics Ⅰ．Penicillin 1321

58．Antibiotics (Continued) Ⅱ．Streptomycin and Dihydrostreptomycin 1360

59．Antibiotics (Continued) Ⅲ．The Tetracyclines：Chlortetracycline，Oxytetracycline，and Tetracycline 1378

60．Antibiotics (Continued) Ⅳ．Miscellaneous Antibiotics：Chloramphenicol，Erythromycin，Carbomycin，Polymyxin B，Neomycin，Bacitracin，and Tyrothricin 1394

SECTION ⅩⅤ．DRUGS USED IN THE CHEMOTHERAPY OF NEOPLASTIC DISEASE 1414

61．Cytotoxic Drugs，Hormones，and Radioactive Isotopes 1415

SECTION ⅩⅥ．DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANS 1451

62．Drugs Effective in Iron-Deficiency Anemias 1451

63．Drugs Effective in Pernicious Anemia and Allied Megaloblastic Anemias Cyanocobalamin (Vitamin B12)，Liver Extract，and Folic Acid 1478

64．Anticoagulants Heparin and Bishydroxycoumarin，and Their Congeneric Substitutes 1500

SECTION ⅩⅦ．HORMONES AND HORMONE ANTAGONISTS 1528

65．Thyroid and Antithyroid Drugs 1528

66．Parathyroid 1566

67．Anterior Pituitary and Anterior Pituitary-Like Hormones 1573

68．Estrogens and progestogens 1589

69．Androgens 1609

70．Insulin 1620

71．Adrenocorticotropic Hormone and Adrenocortical Steroids 1642

SECTION ⅩⅧ．THE VITAMINS 1692

72．Water-Soluble Vitamins Ⅰ．The Vitamin B Complex 1692

73．Water-Soluble Vitamins (Continued) Ⅱ．Ascorbic Acid (Vitamin C) 1720

74．Fat-Soluble Vitamins Ⅰ．Vitamin A and Vitamin D 1728

75．Fat-Soluble Vitamins (Continued) Ⅱ．Vitamin K and Vitamin E 1746

Appendix Ⅰ．Principles of Prescription Writing 1759

Appendix Ⅱ．General Principles of Toxicology 1777

INDEX 1781