ADVANCES IN RADIOBIOLOGYPDF电子书下载

SECTION Ⅰ INITIAL OR PRIMARY CHEMICAL EFFECTS OF IRRADIATION 1

Radiation sensitivity of molecules in intact cells&F.HUTCHINSON 3

The relative importance of direct and indirect radiochemical processes in radiobiology&P.ALEXANDER 8

The biological action of ionising radiations from the point of view of radiation chemistry&G.STEIN and A.J.SWALLOW 16

SECTION Ⅱ BIOCHEMICAL IRRADIATION EFFECTS—ON ENZYMES AND OTHER CELLULAR CONSTITUENTS 25

X-ray inactivation of the components of the succinic acid dehydrogenase-cytochrome-cytochrome oxidase-system&B.RAIEWSKY, G.GERBER and H.PAULY 25

Effects of ionising radiation on the in vivo incorporation of amino acids into proteins&J.A.V.BUTLER, P.COHN and A.R.CRATHORN 33

The combined action of χ-rays and chemical inhibitors on in vitro kidney transport and respiration&M.L.MENDELSOHN 38

Primary biochemical effects in the X-irradiated Yoshida ascites sarcoma&G.HOHNE, H.A.KUNKEL,H.MAAS,G.H.RATHGEN 43

The incorporation of 32P into liver phospholipids and RNA mononucleo-tides of irradiated and non-irradiated mice&F.G.SHERMAN and A.B.ALMEIDA 49

Effects of irradiation on DNA synthesis by human bone marrow cells in vitro&L.G.LAJTHA, R.OLIVER and F.ELLIS 54

Effect of various doses of χ-rays—whole body and local irradiation—on the nucleic acids of the bone marrow&P.MANDEL, C.M.GROS, J.RODESCH, C.JAUDEL and P.CHAMBON 59

The effect of χ-radiation on rat thymus nucleic acids at short intervals after exposure in vivo&M.G.ORD and L.A.STOCKEN 65

SECTION Ⅲ PHYSIOLOGICAL AND MORPHOLOGICAL IRRADIATION CHANGES 71

Prolongation of the clotting time of peritoneal fluid after χ-irradiation&D.E.SMITH and Y.S.LEWIS 73

The participation of the peripheral nervous system in the reaction to irradiation&V.SLOUKA 76

The effects of lethally damaged cells upon survivors in χ-irradiated experi-mental tumours&L.REVESZ 80

Induction of chromosome breaks in the Yoshida sarcoma ascites cells of the rat by χ-rays and fast electrons at different oxygen partial pressures&W.DITTRICH 86

Observations on bacterial growth and morphology shortly after irradiation and some remarks on the oxygen effect&T.ALPER 90

SECTION Ⅳ ALPHA PARTICLE IRRADIATION OF SINGLE CELLS 103

The ‘shooting’ of bacteria one at a time by single alpha particles&R.J.MUNSON 105

Alpha irradiation of parts of single metaphase cells in chick tissue cultures&R.MUNRO 108

The irradiation of single cells and parts of single cells in tissue culture with microbearms of alpha-particles&M.I.DAVIS, I.SIMON-REUSS and C.L.SMITH 114

SECTION Ⅴ MODIFICATION OF SYSTEMIC IRRADIATION EFFECTS 121

Ⅰ.GENERAL PRINCIPLES 123

The effects of pre- and post-treatment on the radiation sensitivity of micro-organisms&A.HOLLAENDER 123

The present status of radiation protec-tion by chemicals and biological agents in mammals&J.A.COHEN, O.VOS and D.W.VAN BEKKUM 134

Ⅱ.CHEMICAL METHODS: EFFECTS OF CYSTEAMINE CYSTEIN AND RELATED COMPOUNDS 147

Studies on the mechanism of protection against ionising radiation by com-pounds of the cysteamine-cysteine group&A.PIHL and L.ELDJARN 147

Recent research on the chemical protectors and particularly on cyste-amine-cystamine&Z.M.BACQ 160

The problem and constitution of radiation-sensitising agents&R.KOCH 170

Radiobiological investigations on the hibernating loir （glis glis）&H.A.KUNKEL, G.HOHNE and H.MAASS 176

The dose reduction factor for cyste-amine and isothiuronium in the case of whole body χ-irradiated mice and rats&A.CATSCH 181

Chemical and biological action of protective SH-compounds&U.HAGEN 187

A bacteriological test for the study of radioprotection problems in mammals&H.MARCOCICH and J.F.DUPLAN 192

Ⅲ.TRANSFER OF CELLULAR MATERIAL—IRRADIATION AND IMMUNE REACTIONS 197

Studies of radiation chimaeras by the use of chromosome markers&C.E.FORD, J.L.HAMERTON, D.W.H.BARNES and J.F.LOUTIT 197

The cell factor in spleen homogenates after irradiation&J.SOSKA, V.DRASIL and Z.KARPFEL 204

Some experiments in favour of the cellular hypothesis. for the spleen curative factor&D.W.H.BARNES, M.P.ESNOUF and L.A.STOCKEN 211

Studies on the mechanism of post-irradiation protection&E.L.SIMMONS, L.O.JACOBSON and J.DENKO 214

The influence of ionising radiation upon the natural immunity&V.L.TROITSKY, M.A.TUMANJAN and A.J.FRIEDENSTEIN 221

Ⅳ.OTHER-APPROACHES TO THE MODIFICATION OF IRRADIATION EFFECTS 226

Modification of the χ-ray reaction in the skin of mice by shielding of minute areas of the skin&F.DEVIK 226

Changes in the reactivity of the organ-ism under the influence of ionising radiation&O.BOGOMOLETS, A.BOICO,G.DIAIDJUCHA, Z.ZEKHOVA,V.LAVRICK and G.LEVTCHOUK 231

Irradiation and adrenal and pituitary function&Z.M.BACQ, P.MARTINOVIC,P.FISCHER, M.PAVLOVIC and G.SLADIC 237

Alkoxyglycerol esters in irradiation treatment&A.BROHULT 241

The protective effect of the rgduc-tion of the body temperature on adult and young mice after whole-body irradiation&S.HORNSEY 248

SECTION Ⅵ THE TIME FACTOR IN RADIOBIOLOGY 255

The effect of repeated small doses on the fertility of the white mouse&H.and M.LANGENDORFF 257

Effects of radiation on ageing&H.J.CURTIS and R.HEALEY 261

Studies on the time-intensity factor after whole-body χ-irradiation&B.RAJEwsKY, K.AURAND and I.WOLF 267

Restoration of primordial follicles in the irradiated oyary&P.DESAIVE 274

Effects of long-term irradiation on lysogenic bacteria&H.MARCOVICH and R.LATARJET 281

SECTION Ⅶ STUDIES ON THE DISTRIBUTION OF ISOTOPES IN TISSUES 285

Changes in the rabbit tibia and an estimation of the dose received by the bone tissue following a single injection of strontium&M.OWEN and J.VAUCHAN 287

Bone and radiostrontium—an attempt to evaluate the dose distribution&F.BJORNERSTEDT, C.-J.CLEMEDSON, A.ENGSTROM,and A.NELSON 294

Decontamination studies.（A simple in vitro system to study the interaction of radioactive metals with proteins from body Buids and tissues）&R.LEWIN,B.ROSOFF,H.E.HART, K.G.STERN and D.LASZLO 298

Iodinated tyrosines and radiosensitivity in thyrotoxicosis&J.D.ABBATT and H.E.A.FARRAN 305

The radiation exposure of the organism by inhalation of naturally radioactive aerosols&W.JACOBI,K.AURAND and A.SCHRAUB 310

SECTION Ⅷ IRRADIATION EFFECTS ON THE HAEMOPOIETIC SYSTEM 319

Ⅰ.ERYTHROPOIESIS 321

Effect of whole-body irradiation and various drugs on erythropoietic func-tion in the rat.Studies with radio-active iron&L.F.LAMERTON and E.H.BELCHER 321

In vivo uptake of radioactive iron by the erythroid cells of rat bone marrow&E.B.HARRISS 333

Erythropoietic activity in irradiated rats injected with homologous and heterologous bone marrow study with 59Fe&H.MAISIN, A.DuNJIC,P.MALDAGUE and J.MAISIN 341

Quantitative changes in the erythro-poietic cells of the rat bone marrow during the first forty-eight hours after whole-body χ-irradiation&E.V.HULSE 349

The life span of red cells of the rhesus monkey following whole-body χ-radiation&C.W.GILBERT, E.PATERSON and M.V.HAIGH 357

Ⅱ.OTHER HAEMOPOIETIC FUNCTIONS 361

Read-off methods in radiohaemato-logical control&M.HELDE 361

Comparison of the physiological response to radiation and radiomimetic chemicals Patterns of blood response&L.A.ELSON 372

The effect of whole body χ-irradiation on the megakaryocytic system in rat femur&B.LINDELL and J.ZAJICEK 376

The immediate effects of large doses of radioactive phosphorus on the peripheral blood compared with those of external irradiation in patients with malignant disease&E.M.LEDLIE 382

Ⅲ.RADIATION LEUKAEMIA 388

Induction of leukaemia by radiation&J.F.LOUTIT 388

Radiation induced leukaemia in Denmark&M.FABER 397

SECTION Ⅸ RADIATION GENETICS 405

Principles of back mutation as observed in Drosophila and other organisms&H.J.MULLER and I.I.OSTER 407

Genetic implications of irradiation in man&T.C.CARTER 416

The induction of detrimental muta-tions in Drosophila by χ-rays&K.G.LUNING and S.JONSSON 425

Rate of development of χ-ray induced detrimentals and the influence of selection pressure&G.BONNIER 433

Comparison of chemically and χ-ray induced mutations in Drosophila melanogaster&O.G.FAHMY and M.J.FAHMY 437

The possible role of peroxides in radiation and chemical mutagenesis in Drosophila&F.H.SOBELS 449

Incorporation and mutagenicity of 32P in Drosophila sperm&P.OFTEDAL and J.C.MOSSIGE 457

Recent studies on chromosome break-age and rejoining&S.WOLFF 463

Modification of χ-ray mutagenesis in Drosophila&I.I.OSTER 475

Recovery of chromosomes from χ-ray damage&K.NORDBACK and C.AUERBACH 481

LIST OF PARTICIPANTS 487

SUBJECT INDEX 494

INDEX TO CONTRIBUTORS 501