SECTION Ⅰ INITIAL OR PRIMARY CHEMICAL EFFECTS OF IRRADIATION 1
Radiation sensitivity of molecules in intact cells&F.HUTCHINSON 3
The relative importance of direct and indirect radiochemical processes in radiobiology&P.ALEXANDER 8
The biological action of ionising radiations from the point of view of radiation chemistry&G.STEIN and A.J.SWALLOW 16
SECTION Ⅱ BIOCHEMICAL IRRADIATION EFFECTS—ON ENZYMES AND OTHER CELLULAR CONSTITUENTS 25
X-ray inactivation of the components of the succinic acid dehydrogenase-cytochrome-cytochrome oxidase-system&B.RAIEWSKY, G.GERBER and H.PAULY 25
Effects of ionising radiation on the in vivo incorporation of amino acids into proteins&J.A.V.BUTLER, P.COHN and A.R.CRATHORN 33
The combined action of χ-rays and chemical inhibitors on in vitro kidney transport and respiration&M.L.MENDELSOHN 38
Primary biochemical effects in the X-irradiated Yoshida ascites sarcoma&G.HOHNE, H.A.KUNKEL,H.MAAS,G.H.RATHGEN 43
The incorporation of 32P into liver phospholipids and RNA mononucleo-tides of irradiated and non-irradiated mice&F.G.SHERMAN and A.B.ALMEIDA 49
Effects of irradiation on DNA synthesis by human bone marrow cells in vitro&L.G.LAJTHA, R.OLIVER and F.ELLIS 54
Effect of various doses of χ-rays—whole body and local irradiation—on the nucleic acids of the bone marrow&P.MANDEL, C.M.GROS, J.RODESCH, C.JAUDEL and P.CHAMBON 59
The effect of χ-radiation on rat thymus nucleic acids at short intervals after exposure in vivo&M.G.ORD and L.A.STOCKEN 65
SECTION Ⅲ PHYSIOLOGICAL AND MORPHOLOGICAL IRRADIATION CHANGES 71
Prolongation of the clotting time of peritoneal fluid after χ-irradiation&D.E.SMITH and Y.S.LEWIS 73
The participation of the peripheral nervous system in the reaction to irradiation&V.SLOUKA 76
The effects of lethally damaged cells upon survivors in χ-irradiated experi-mental tumours&L.REVESZ 80
Induction of chromosome breaks in the Yoshida sarcoma ascites cells of the rat by χ-rays and fast electrons at different oxygen partial pressures&W.DITTRICH 86
Observations on bacterial growth and morphology shortly after irradiation and some remarks on the oxygen effect&T.ALPER 90
SECTION Ⅳ ALPHA PARTICLE IRRADIATION OF SINGLE CELLS 103
The ‘shooting’ of bacteria one at a time by single alpha particles&R.J.MUNSON 105
Alpha irradiation of parts of single metaphase cells in chick tissue cultures&R.MUNRO 108
The irradiation of single cells and parts of single cells in tissue culture with microbearms of alpha-particles&M.I.DAVIS, I.SIMON-REUSS and C.L.SMITH 114
SECTION Ⅴ MODIFICATION OF SYSTEMIC IRRADIATION EFFECTS 121
Ⅰ.GENERAL PRINCIPLES 123
The effects of pre- and post-treatment on the radiation sensitivity of micro-organisms&A.HOLLAENDER 123
The present status of radiation protec-tion by chemicals and biological agents in mammals&J.A.COHEN, O.VOS and D.W.VAN BEKKUM 134
Ⅱ.CHEMICAL METHODS: EFFECTS OF CYSTEAMINE CYSTEIN AND RELATED COMPOUNDS 147
Studies on the mechanism of protection against ionising radiation by com-pounds of the cysteamine-cysteine group&A.PIHL and L.ELDJARN 147
Recent research on the chemical protectors and particularly on cyste-amine-cystamine&Z.M.BACQ 160
The problem and constitution of radiation-sensitising agents&R.KOCH 170
Radiobiological investigations on the hibernating loir （glis glis）&H.A.KUNKEL, G.HOHNE and H.MAASS 176
The dose reduction factor for cyste-amine and isothiuronium in the case of whole body χ-irradiated mice and rats&A.CATSCH 181
Chemical and biological action of protective SH-compounds&U.HAGEN 187
A bacteriological test for the study of radioprotection problems in mammals&H.MARCOCICH and J.F.DUPLAN 192
Ⅲ.TRANSFER OF CELLULAR MATERIAL—IRRADIATION AND IMMUNE REACTIONS 197
Studies of radiation chimaeras by the use of chromosome markers&C.E.FORD, J.L.HAMERTON, D.W.H.BARNES and J.F.LOUTIT 197
The cell factor in spleen homogenates after irradiation&J.SOSKA, V.DRASIL and Z.KARPFEL 204
Some experiments in favour of the cellular hypothesis. for the spleen curative factor&D.W.H.BARNES, M.P.ESNOUF and L.A.STOCKEN 211
Studies on the mechanism of post-irradiation protection&E.L.SIMMONS, L.O.JACOBSON and J.DENKO 214
The influence of ionising radiation upon the natural immunity&V.L.TROITSKY, M.A.TUMANJAN and A.J.FRIEDENSTEIN 221
Ⅳ.OTHER-APPROACHES TO THE MODIFICATION OF IRRADIATION EFFECTS 226
Modification of the χ-ray reaction in the skin of mice by shielding of minute areas of the skin&F.DEVIK 226
Changes in the reactivity of the organ-ism under the influence of ionising radiation&O.BOGOMOLETS, A.BOICO,G.DIAIDJUCHA, Z.ZEKHOVA,V.LAVRICK and G.LEVTCHOUK 231
Irradiation and adrenal and pituitary function&Z.M.BACQ, P.MARTINOVIC,P.FISCHER, M.PAVLOVIC and G.SLADIC 237
Alkoxyglycerol esters in irradiation treatment&A.BROHULT 241
The protective effect of the rgduc-tion of the body temperature on adult and young mice after whole-body irradiation&S.HORNSEY 248
SECTION Ⅵ THE TIME FACTOR IN RADIOBIOLOGY 255
The effect of repeated small doses on the fertility of the white mouse&H.and M.LANGENDORFF 257
Effects of radiation on ageing&H.J.CURTIS and R.HEALEY 261
Studies on the time-intensity factor after whole-body χ-irradiation&B.RAJEwsKY, K.AURAND and I.WOLF 267
Restoration of primordial follicles in the irradiated oyary&P.DESAIVE 274
Effects of long-term irradiation on lysogenic bacteria&H.MARCOVICH and R.LATARJET 281
SECTION Ⅶ STUDIES ON THE DISTRIBUTION OF ISOTOPES IN TISSUES 285
Changes in the rabbit tibia and an estimation of the dose received by the bone tissue following a single injection of strontium&M.OWEN and J.VAUCHAN 287
Bone and radiostrontium—an attempt to evaluate the dose distribution&F.BJORNERSTEDT, C.-J.CLEMEDSON, A.ENGSTROM,and A.NELSON 294
Decontamination studies.（A simple in vitro system to study the interaction of radioactive metals with proteins from body Buids and tissues）&R.LEWIN,B.ROSOFF,H.E.HART, K.G.STERN and D.LASZLO 298
Iodinated tyrosines and radiosensitivity in thyrotoxicosis&J.D.ABBATT and H.E.A.FARRAN 305
The radiation exposure of the organism by inhalation of naturally radioactive aerosols&W.JACOBI,K.AURAND and A.SCHRAUB 310
SECTION Ⅷ IRRADIATION EFFECTS ON THE HAEMOPOIETIC SYSTEM 319
Ⅰ.ERYTHROPOIESIS 321
Effect of whole-body irradiation and various drugs on erythropoietic func-tion in the rat.Studies with radio-active iron&L.F.LAMERTON and E.H.BELCHER 321
In vivo uptake of radioactive iron by the erythroid cells of rat bone marrow&E.B.HARRISS 333
Erythropoietic activity in irradiated rats injected with homologous and heterologous bone marrow study with 59Fe&H.MAISIN, A.DuNJIC,P.MALDAGUE and J.MAISIN 341
Quantitative changes in the erythro-poietic cells of the rat bone marrow during the first forty-eight hours after whole-body χ-irradiation&E.V.HULSE 349
The life span of red cells of the rhesus monkey following whole-body χ-radiation&C.W.GILBERT, E.PATERSON and M.V.HAIGH 357
Ⅱ.OTHER HAEMOPOIETIC FUNCTIONS 361
Read-off methods in radiohaemato-logical control&M.HELDE 361
Comparison of the physiological response to radiation and radiomimetic chemicals Patterns of blood response&L.A.ELSON 372
The effect of whole body χ-irradiation on the megakaryocytic system in rat femur&B.LINDELL and J.ZAJICEK 376
The immediate effects of large doses of radioactive phosphorus on the peripheral blood compared with those of external irradiation in patients with malignant disease&E.M.LEDLIE 382
Ⅲ.RADIATION LEUKAEMIA 388
Induction of leukaemia by radiation&J.F.LOUTIT 388
Radiation induced leukaemia in Denmark&M.FABER 397
SECTION Ⅸ RADIATION GENETICS 405
Principles of back mutation as observed in Drosophila and other organisms&H.J.MULLER and I.I.OSTER 407
Genetic implications of irradiation in man&T.C.CARTER 416
The induction of detrimental muta-tions in Drosophila by χ-rays&K.G.LUNING and S.JONSSON 425
Rate of development of χ-ray induced detrimentals and the influence of selection pressure&G.BONNIER 433
Comparison of chemically and χ-ray induced mutations in Drosophila melanogaster&O.G.FAHMY and M.J.FAHMY 437
The possible role of peroxides in radiation and chemical mutagenesis in Drosophila&F.H.SOBELS 449
Incorporation and mutagenicity of 32P in Drosophila sperm&P.OFTEDAL and J.C.MOSSIGE 457
Recent studies on chromosome break-age and rejoining&S.WOLFF 463
Modification of χ-ray mutagenesis in Drosophila&I.I.OSTER 475
Recovery of chromosomes from χ-ray damage&K.NORDBACK and C.AUERBACH 481
LIST OF PARTICIPANTS 487
SUBJECT INDEX 494
INDEX TO CONTRIBUTORS 501