临床药理学 英文原版 4版PDF电子书下载

PART 1 1

Introduction 1

INTRODUCTION TO CLINICAL PHARMACOLOGY AND RATIONAL THERAPEUTICS David W.Nierenberg, Kenneth L.Melmon 3

PART 2 63

Drug Therapy of Common Diseases: Problem-Based Therapeutic Decisions 63

CHAPTER 1 65

CARDIOVASCULAR DISORDERS 65

Hypertension Brian B.Hoffman, S.George Carruthers 65

Hypotension David Robertson 95

Coronary Artery Disease Thomas Michel, Mark S.Weinfeld 114

Acute Myocardial Infarction Christopher P.Cannon, Peter H.Stone 131

Heart Failure J.Malcolm O.Arnold 157

Arrhythmias Dan M.Roden 183

Peripheral Arterial Occlusive Disease Thomas L.Whitsett 207

Venous Thromboembolic Disease Brian G.Birdwell, Thomas L.Whitsett 214

Adverse Effects of Cardiovascular Drugs on the Cardiovascular System Stanley Nattel 229

CHAPTER 2 235

Introduction and General Approach to Therapy John A.Abisheganaden, Homer A.Boushey 235

Obstructive Lung Diseases: Treatment John A.Abisheganaden, Homer A.Boushey, Stephen I.Rennard 238

Asthma John A.Abisheganaden, Homer A.Boushey 260

Chronic Obstructive Pulmonary Disease Stephen I.Rennard 265

Cystic Fibrosis Moira L.Aitken, Mark Tonelli 271

Pneumonia Michael S.Niederman 275

Pulmonary Vascular Disease Sean P.Gaine 289

Idiopathic Pulmonary Fibrosis Naseema B.Merchant, Paul W.Noble 293

Drug-Induced Lung Disease Naseema B.Merchant, Paul W.Noble 297

CHAPTER 3 303

GASTRO, NTESTINAL DISORDERS Gabriel Garcia 303

CHAPTER 4 319

HEPATR DISORDERS AND THE INFLUENCE OF LIVER FGNCIION ON DRUG DISPOSITION Gabriel Garcia 319

CHAPTER 5 341

? Elizabeth M.Ross, Irwin H.Rosenberg 341

CHAPTER 6 363

? D.Craig Brater 363

CHAPTER 7 401

? 401

Headache Thomas N.Ward 401

Seizures Richard S.McLachlan 411

Cerebrovascular Diseases Arturo Tamayo, Vladimir Hachinski 423

Parkinson s Disease David J.Coffey 437

Dementia Lawrence R.Jenkyn 445

Multiple Sclerosis: Current Treatment G.P.A.Rice,George C.Ebers 453

Myasthenia Gravis Michael W.Nicolle 460

Drug-Induced Neurologic Disorders B.M.Demaerschalk, P.E.Cooper 480

CHAPTER 8 489

PSYOHATRIC DISORDERS Leo E.Hollister 489

CHAPTER 9 529

ENDC CRINE AND MEFABOHC DISORDERS 529

Diabetes Mellitus Jeffrey W.Miller, Fredric B.Kraemer 529

Dyslipidemias Fredric B.Kraemer, Jeffery W.Miller 552

Adrenal Steroids Jeffrey W.Miller 581

Thyroid Disease Jeffrey W.Miller 594

Reproductive Steroids Jeffrey W.Miller 610

Hypothalamic Hormone Therapy Steven A.Lieberman, Andrew R.Hoffman 637

CHAPTER 10 645

CONNECTIVE TISSUE AND BONE DISORDERS 645

Rheumatic Disorders Richard Day, David Quinn, Kenneth Williams, Malcolm Handel, Peter Brooks 645

Osteoporosis Robert Marcus 703

CHAPTER 11 713

DERMATOLOGIC DISORDERS Christopher M.Barnard, Marc E.Coldyne 713

CHAPTER 12 737

HEM TOIOGIC DISORDERS Richard Lin, Zhuo-Wei Hu 737

ONCOLOGIC DISORDERS Joseph R.Bertino, Owen A.O Connor 799

CHAPTER 13 799

CHAPTER 14 873

INFECTIOUS DISORDERS Thomas J.Marrie,Claire Touchie,B.Lynn Johnston, Kevin R.Forward, Kathryn L.Slayter, Spencer Lee, Paul Hoffman 873

CHAPTER 15 1003

CONSCIOUS SEDATION AND PAN Mervyn Maze ,John C.Hunter, Raymond R.Gaeta 1003

CHAPTER 16 1029

TREATMENT IN THE INTENSIVE CARE UNIT David J.Liepert, Ronald G.Pearl 1029

CHAPTER 17 1053

SUBSTANCE ABUSE: DEPENDENCE AND TREATMENT Lori D.Karan, Neal L.Benowitz 1053

CHAPTER 18 1091

POISONING Lewis S.Nelson, Lewis R.Goldfrank 1091

PART 3 1115

Core Topics in Clinical Pharmacology 1115

DRUG THERAPY IN PREGNANT AND BREAST-FEEDING WOMEN Peter C.Rubin, Jane M.Rutherford 1117

CHAPTER 19 1117

CHAPTER 20 1143

DRUG THERAPY IN PEDIATRIC PATIENTS Ronen Loebstein, Sunita Vohra, Gideon Koren 1143

CHAPTER 21 1151

GERIATRIC PHARMACOLOGY Robert E.Vestal, Jerry H.Gurwitz 1151

CHAPTER 22 1179

PHARMACOGENETICS Urs A.Meyer 1179

CHAPTER 23 1207

CLINICAL PHARMACOKINETICS AND PHARMACODYNAMICS Daniel S.Sitar 1207

CHAPTER 24 1223

ADVERSE DRUG REACTIONS David W.Bates, Lucian Leape 1223

DRUG INTERACTIONS James M.Wright 1257

CHAPTER 25 1257

CHAPTER 26 1267

WRITING PRESCRIPTIONS Terrence F.Blaschke 1267

CHAPTER 27 1289

DRUG DISCOVERY AND DEVELOPMENT Richard D.Mamelok 1289

CHAPTER 28 1307

RISK ANALYSIS APPLIED TO PRESCRIPTION DRUGS John Urquhart 1307

CHAPTER 29 1319

THE CLINICIAN S ACTIONS WHEN N=1 Gordon Guyatt, David L.Sackett 1319

CHAPTER 30 1329

INFORMATION ABOUT DRUGS: A CLINICAL EPIDEMIOLOGIC APPROACH TO THERAPEUTICS Brian L.Strom 1329

Appendix 1341

Index 1347