Histopathology Of The SkinPDF电子书下载

1．INTRODUCTION 1

Technic for Biopsy 1

Limitations of Histologic Diagnosis 2

2．EMBRYOLOGY OF THE SKIN 3

The Epidermis 3

The Dermis 5

3．HISTOLOGY OF THE SKIN 8

The Epidermis 8

The Epidermal Appendages 16

The Dermis 23

4．LABORATORY METHODS 34

Fixation,Processing and Staining 34

Histochemical Staining 36

Polariscopic Examination 37

5．MORPHOLOGY OF THE MESODERMAL CELLS 39

Myeloid Group 39

Lymphoid Group 40

Reticulohistiocytic Group 41

Plasma Cells 43

Mast Cells 44

6．CONGENITAL DISEASES(GENODERMATOSES) 48

Ichthyosis 48

Ichthyosis Vulgaris 48

Ichthyosis Congenita 48

Congenital Ichthyosiform Erythroderma 49

Keratosis Palmaris et Plantaris 51

Keratosis Punctata Palmaris et Plantaris 51

Pachyonychia Congenita 51

Dyskeratosis Congenita 52

Porokeratosis Mibelli 52

Xeroderma Pigmentosum 53

Congenital Ectodermal Defect 54

Rothmund＇s Syndrome(Poikiloderma Congenitale),Werner＇s Syndrome(Progeria of Adults)and progeria of Children 55

Epidermolysis Bullosa 56

Darier＇s Disease(Keratosis Follicularis) 58

Familial Benign Chronic Pemphigus 61

Acrokeratosis Verruciformis 63

Pseudoxanthoma Elasticum 64

Juvenile Elastoma(Nevus Elasticus) 66

Cutis Hyperelastica(Ehlers-Danlos Syndrome) 67

Urticaria Pigmentosa 68

Incontinentia Pigmenti 71

7．NONINFECTIOUS VESICULAR AND BULLOUS DISEASES 79

Dermatitis-Eczema 81

Dermatopathic Lymphadenitis 90

Miliaria 91

Pompholyx(Dyshidrotic Eruption) 92

Erythema Toxicum Neonatorum 93

Pemphigus 94

Pemphigus Vulgaris 94

Pemphigus Vegetans 97

Pemphigus Foliaceus 99

Pemphigus Erythematosus 101

Bullous Pemphigoid 102

Benign Mucous-Membrane Pemphigoid(Cicatricial Pemphigoid,Pemphigus Conjunctivae) 105

Erythema Multiforme 105

Dermatitis Herpetiformis 106

Subcorneal Pustular Dermatosis 107

Burn 109

8．NONINFECTIOUS INFLAMMATORY DISEASES 114

Urticaria 114

Erythema Annulare Centrifugum 114

Prurigo Nodularis 115

Erythema Nodosum 116

Nodular Vasculitis 119

Psoriasis 119

Pustular Psoriasis,Acrodermatitis Continua,Impetigo Herpetiformis 122

Reiter＇s Disease 125

Pustulosis Palmaris et Plantaris(Pustular Bacterid) 127

Parapsoriasis 128

Pityriasis Varioliformis Acuta 129

Pityriasis Rosea 130

Lichen Planus 131

Lichen Nitidus 135

Lichen Striatus 136

Pityriasis Rubra Pilaris 137

Granuloma Faciale 137

Erythema Elevatum Diutinum 140

Granuloma Annulare 140

Subcutaneous Nodules of Rheumatic Fever and Rheumatoid Arthritis 143

Acrodermatitis Chronica Atrophicans 145

Radiodermatitis 146

Polymorphous Light Eruption(Solar Dermatitis) 149

Acne Vulgaris 152

Acne Varioliformis(Acne Necrotica Miliaris) 152

Acne Rosacea 153

Fox-Fordyce Disease 154

Hidrocystoma 155

Alopecia Areata 156

Alopecia Cicatrisata(Pseudopelade Brocq) 156

Alopecia Mucinosa 157

Purpura 159

Noninflammatory Purpura 159

Inflammatory Purpura(Vasculitis) 160

Purpura Pigmentosa Chronica(Majocchi-Schamberg) 164

Relapsing Febrile Nodular Nonsuppurative Panniculitis(Weber-Christian Disease) 166

Sclerema Neonatorum 168

Hereditary Edema of the Legs(Milroy＇s Disease) 170

Chondrodermatitis Helicis and Anthelicis 170

Scabies 172

Arthropod Bites 174

Lichen Urticatus(Papular Urticaria) 174

Foreign-Body Granulomas 175

Lipid Granuloma(Paraffinoma) 176

Tattoo Granuloma 177

Silica Granuloma 177

Zirconium Granuloma 178

Beryllium Granuloma 179

Swimming-Pool Granuloma 180

9．ERUPTIONS DUE TO DRUGS 192

Fixed Drug Eruption 192

Quinacrine Hydrochloride(Atabrine)Dermatitis 192

Exfoliative Dermatitis Due to Drugs 193

Hydralazine(Apresoline)Eruption 193

Bromoderma 193

Iododerma 195

Argyria 195

Chrysiasis 197

Arsenical Keratosis and Carcinoma 197

10．DEGENERATIVE DISEASES 200

Senile Degeneration 200

Elastosis Perforans Serpiginosa(Miescher) 202

Hyperkeratosis Follicularis in Cutem Penetrans(Kyrle) 205

Lichen Sclerosus et Atrophicus 205

Kraurosis Vulvae 207

Balanitis Xerotica Obliterans 209

Striae Distensae 210

Macular Atrophy(Anetoderma) 210

Atrophia Alba(Milian) 210

Atrophoderma Reticulatum(Folliculitis Ulerythematosa Reticulata) 211

Colloid Milium(Colloid Degeneration of the Skin) 211

11．BACTERIAL DISEASES 217

Impetigo 217

Erysipelas 218

Folliculitis(Impetigo Bockhart,Furuncle,Folliculitis Barbae) 218

Folliculitis Keloidalis(Dermatitis Papillaris Capillitii) 219

Hidradenitis Suppurativa 219

Pyoderma Gangrenosum(Chronic Undermining Burrowing Ulcer) 220

Aphthosis 221

Meningococcemia(Waterhouse-Friderichsen Syndrome) 221

Tuberculosis 222

Primary Tuberculosis 224

Reinfection Tuberculosis 225

Sarcoidosis 234

Cheilitis Granulomatosa 240

Leprosy 241

Diphtheria of the Skin 245

Anthrax 246

Tularemia 246

Chancroid 247

Granuloma Inguinale 248

Rhinoscleroma 250

12．SPIROCHETAL DISEASES 257

Syphilis 257

Yaws(Frambesia Tropica) 265

Pinta 266

13．FUNGAL DISEASES 269

Dermatophytosis(Tinea) 269

Moniliasis 273

North American Blastomycosis(Gilchrist＇s Disease) 275

South American Blastomycosis(Paracoccidioidomycosis) 278

Chromoblastomycosis 279

Cryptococcosis(Torulosis) 281

Coccidioidomycosis(San Joaquin Valley Fever) 282

Actinomycosis,Nocardiosis 285

Sporotrichosis 287

Histoplasmosis 289

14．DISEASES CAUSED BY PROTOZOA 294

Cutaneous Leishmaniasis 294

Mucocutaneous Leishmaniasis 296

15．DISEASES CAUSED BY VIRUSES 298

Variola,Varicella,Herpes Zoster,Herpes Simplex 298

Eczema Vaccinatum and Eczema Herpeticum(Kaposi＇s Varicelliform Eruption) 304

Molluscum Contagiosum 305

Verruca 308

Verruca Vulgaris 308

Verruca Plana 311

Verruca Plantaris 312

Condyloma Acuminatum 312

Lymphogranuloma Venereum(Lymphogranuloma Inguinale,Lymphopathia Venerea) 314

Milkers＇ Nodules 315

Ecthyma Contagiosum(Orf) 316

16．METABOLIC DISEASES 320

Lipoidoses 320

Systemic Lipoidoses with Increased Serum Lipids 320

Systemic Lipoidoses with Normal Serum Lipids 326

Purely Cutaneous Lipoidoses with Normal Blood Lipids 336

Amyloidosis 343

Primary Systemic Amyloidosis 344

Lichen Amyloidosus 347

Localized Nodular Amyloidosis 347

Calcinosis Cutis 348

Metastatic Calcification 348

Dystrophic Calcification 349

Gout 350

Porphyria 351

Myxedema 352

Generalized Myxedema 353

Circumscribed Myxedema 353

Lichen Myxedematosus 354

Scleredema Adultorum(Buschke) 355

Addison＇s Disease 356

Acanthosis Nigricans 357

Riehl＇s Melanosis,Melanodermatitis Toxica 358

Vitiligo 360

Hemochromatosis(Bronze Diabetes) 360

Ochronosis 361

Vitamin A Deficiency(Phrynoderma) 362

Pellagra 362

Vitamin C Deficiency(Scurvy) 363

17．SYSTEMIC DISEASES OF UNKNOWN CAUSE 372

Lupus Erythematosus 372

Chronic Discoid Lupus Erythematosus 373

Subacute Disseminated Lupus Erythematosus 376

Acute Systemic Lupus Erythematosus 377

Lupus Erythematosus Profundus 383

Lymphocytic Infiltration of the Skin(Jessner) 384

Dermatomyositis 385

Poikiloderma Atrophicans Vasculare 388

Scleroderma 390

Circumscribed Scleroderma(Morphea) 390

Systemic Scleroderma 392

Periarteritis Nodosa 394

Wegener＇s Respiratory Granulomatosis 397

Lethal Mid-line granuloma of the Face 398

Malignant Atrophic Papulosis(Degos) 399

18．EPIDERMAL TUMORS 406

Histogenesis and Classification of Epidermal Tumors 406

1．Tumors of the Surface Epidermis 410

Nevus Verrucosus 410

Seborrheic Keratosis(Verruca Senilis,Basal Cell Papilloma) 412

Epidermal Cyst,Sebaceous Cyst,Milium,Dermoid Cyst 415

Keratosis Senilis 419

Leukoplakia 423

Squamous Cell Carcinoma(Epidermoid Carcinoma) 425

Keratoacanthoma 433

Bowen＇s Disease 436

Erythroplasia of Queyrat 439

Paget＇s Disease 439

2．Tumors of the Epidermal Appendages 444

Nevus Sebaceus(Jadassohn) 444

Adenoma Sebaceum(Pringle)(Tuberous Sclerosis) 446

Senile Sebaceous Nevus(Senile Sebaceous Hyperplasia) 447

Fordyce＇s Disease 448

Apocrine-Gland Nevus 448

Hair Nevus 449

Sebaceous Adenoma 449

Syringocystadenoma Papilliferum(Nevus Syringocyst-adenomatosus Papilliferus) 450

Hidradenoma Papilliferum 454

Folliculoma(Hair-Follicle Tumor) 456

Sebaceous Epithelioma 457

Syringoma 458

Cylindroma 460

Apocrine Myo-epithelioma 463

Mixed Tumor of the Skin 466

Trichoepithelioma(Epithelioma Adenoides Cysticum,Multiple Benign Cystic Epithelioma) 467

Calcifying Epithelioma 471

Basal Cell Epithelioma 474

Eccrine Spiradenoma 489

Eccrine Poroma 491

Carcinoma of Sebaceous Glands 493

Carcinoma of Eccrine Sweat Glands 494

Carcinoma of Apocrine Glands 495

3．Metastatic Carcinoma of the Skin 496

Cutaneous Metastasis from Carcinoma of the Breast 496

Cutaneous Metastasis from Carcinomas Other Than Breast Carcinoma 498

19．MESODERMAL TUMORS 514

1．Tumors of Fibrous Tissue 514

Dermatofibroma,Histiocytoma(Sclerosing Hemangioma,Nodular Subepidermal Fibrosis) 514

Giant-Cell Reticulohistiocytoma 519

Giant-Cell Epulis 521

Keloid 521

Fibrosarcoma 522

Subcutaneous Fibrosarcoma 522

Dermatofibrosarcoma Protuberans 524

2．Tumors of Mucoid Tissue 525

Myxoma 525

Myxosarcoma 526

Mucous Cyst of the Skin 527

3．Tumors of Fatty Tissue 527

Nevus Lipomatosus Superficialis 527

Lipoma 528

Hibernoma 528

Liposarcoma 530

Malignant Hibernoma 531

4．Tumors of Nerve Tissue 532

Neuroma 532

Neurofibromatosis(von Recklinghausen＇s Disease) 533

Neurilemmoma 537

Cutaneous Meningioma 538

5．Tumors of Vascular Tissue 539

Hemangioma 539

Granuloma Pyogenicum 542

Senile Hemangioma 543

Angiokeratoma Mibelli 544

Angiokeratoma Corporis Diffusum 544

Nevus Araneus 546

Osler＇s Disease(Familial Hemorrhagic Telangiectasia) 546

Lymphangioma 547

Glomus Tumor 548

Hemangiopericytoma 550

Kaposi＇s Sarcoma(Multiple Idiopathic Hemorrhagic Sarcoma) 551

Hemangio-endothelioma 555

Postmastectomy Lymphangiosarcoma 557

6．Tumors of Muscular Tissue 558

Leiomyoma 558

Leiomyosarcoma 560

Granular Cell Myoblastoma 561

Malignant Granular Cell Myoblastoma 564

7．Tumors of Osseus Tissue 564

Osteoma Cutis 564

20．PIGMENTED NEVI AND MALIGNANT MELANOMA 575

Pigmented Nevus 575

Malignant Melanoma 582

Juvenile Melanoma 589

Lentigo 591

Mongolian Spot 592

Blue Nevus 593

21．LYMPHOMA AND MYELOSIS 600

Lymphoma 600

Stem-Cell Lymphoma 604

Reticulum-Cell Lymphoma 605

Lymphoblastic Lymphoma 606

Lymphocytic Lymphoma 608

Follicular Lymphoma(Brill-Symmers) 611

Hodgkin＇s Disease 612

Mycosis Fungoides 615

Generalized Exfoliative Dermatitis in Lymphoma 621

Herpes Zoster in Lymphoma 622

Lymphocytoma Cutis(Lymphadenosis Benigna Cutis;Spiegler-Fendt Sarcoid) 622

Myelosis 625

Plasmacytoma(Multiple Myeloma) 626

Erythremic Myelosis 627

GLOSSARY 631

INDEX 635