Basic & clinical pharmacology = 基础与临床药理学 英文原版PDF电子书下载

Ⅰ.BASIC PRINCIPLES 1

1.Introduction&Bertram G.Katzung, MD, PhD 1

2.Drug Receptors ＆ Pharmacodynamics&Henry R.Bourne, MD, ＆ Mark von Zastrow, MD, PhD 9

3.Pharmacokinetics ＆ Pharmacodynamics: Rational Dosing ＆ the Time Course of Drug Action&Nicholas H.G.Holford, MB, ChB, FRACP 35

4.Drug Biotransformation&Maria Almira Correia, PhD 51

5.Basic ＆ Clinical Evaluation of New Drugs&Barry A.Berkowitz, PhD, ＆ Bertram G.Katzung, MD, PhD 64

Ⅱ.AUTONOMIC DRUGS 75

6.Introduction to Autonomic Pharmacology&Bertram G.Katzung, MD, PhD 75

7.Cholinoceptor-Activating ＆ Cholinesterase-Inhibiting Drugs&Achilles J.Pappano, PhD 92

8.Cholinoceptor-Blocking Drugs&Achilles J.Pappano, PhD, ＆ Bertram G.Katzung, MD, PhD 107

9.Adrenoceptor-Activating ＆ Other Sympathomimetic Drugs&Brian B.Hoffman, MD 120

10.Adrenoceptor Antagonist Drugs&Brian B.Hoffman, MD 138

Ⅲ.CARDIOVASCULAR-RENAL DRUGS 155

11.Antihypertensive Agents&Neal L.Benowitz，MD 155

12.Vasodilators ＆ the Treatment of Angina Pectoris&Bertram G.Katzung, MD, PhD, ＆ Kanu Chatterjee, MB, FRCP 181

13.Cardiac Glycosides ＆ Other Drugs Used in Congestive Heart Failure&Bertram G.Katzung, MD, PhD, ＆ William W.Parmley, MD 200

14.Agents Used in Cardiac Arrhythmias&Luc M.Hondeghem, MD, PhD, ＆ Dan M.Roden, MD 219

15.Diuretic Agents&Harlan E.lves,MD,PhD 245

Ⅳ.DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE 265

16.Histamine, Serotonin, ＆ the Ergot Alkaloids&Bertram G.Katzung, MD, PhD, ＆ David J.Julius, PhD 265

17.Vasoactive Peptides&lan A.Reid, PhD 292

18.The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes,＆ Related Compounds&Marie L.Foegh, MD, DSc, ＆ Peter W.Ramwell, PhD 311

19.Nitric Oxide, Donors, ＆ Inhibitors&George Thomas, PhD, ＆ Peter W.Ramwell, PhD 326

20.Drugs Used in Asthma&Homer A.Boushey, MD 333

Ⅴ.DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM 351

21.Introduction to the Pharmacology of CNS Drugs&Roger A.Nicoll, MD 351

22.Sedative-Hypnotic Drugs&Anthony J.Trevor, PhD, ＆ Walter L.Way, MD 364

23.The Alcohols&Susan B.Masters,PhD 382

24.Antiseizure Drugs&Roger J.Porter, MD,＆ Brian S.Meldrum, MB, PhD 395

25.General Anesthetics&Anthony J.Trevor, PhD,＆Ronald D.Miller, MD 419

26.Local Anesthetics&Ronald D.Miller, MD, ＆ Bertram G.Katzung,MD,PhD 436

27.Skeletal Muscle Relaxants&Ronald D.Miller, MD, ＆ Bertram G.Katzung, MD, PhD 446

28.Pharmacologic Management of Parkinsonism ＆ Other Movement Disorders&Michael J.Aminoff, MD, FRCP 463

29.Antipsychotic Agents ＆ Lithium&William Z.Potter, MD, PhD, ＆ Leo E.Hollister, MD 478

30.Antidepressant Agents&William Z.Potter, MD, PhD, ＆ Leo E.Hollister, MD 498

31.Opioid Analgesics ＆ Antagonists&Walter L.Way,MD,Howard L.Fields,MD,PhD,＆ Mark A.Schumacher, PhD, MD 512

32.Drugs of Abuse&Thomas R.Kosten, MD, and Leo E.Hollister, MD 532

Ⅵ.DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, ＆ GOUT 549

33.Agents Used in Anemias; Hematopoietic Growth Factors&Daniel V.Santi, MD,PhD, ＆ Susan B.Masters, PhD 549

34.Drugs Used in Disorders of Coagulation&Julie Hambleton, MD, ＆ Robert A.O'Reilly, MD 564

35.Agents Used in Hyperlipidemia&Mary J.Malloy, MD, ＆ John P.Kane, MD, PhD 581

36.Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, ＆ Drugs Used in Gout&Daniel E Furst, MD, ＆ Tino Munster, MD 596

Ⅶ.ENDOCRINE DRUGS 625

37.Hypothalamic ＆ Pituitary Hormones&Paul A.Fitzgerald, MD 625

38.Thyroid ＆ Antithyroid Drugs&Francis S.Greenspan, MD, ＆ Betty J.Dong, PharmD 644

39.Adrenocorticosteroids ＆ Adrenocortical Antagonists&George P.Chrousos, MD, ＆ Andrew N.Margions, MD 660

40.The Gonadal Hormones ＆ Inhibitors&George P.Chrousos, MD, Emmanouil N.Zoumakis,PhD, ＆ Achille Gravanis, PhD 679

41.Pancreatic Hormones ＆ Antidiabetic Drugs&Martha S.Nolte, MD, ＆ John H.Karam, MD 711

42.Agents That Affect Bone Mineral Homeostasis&Daniel D.Bikle, MD, PhD 735

Ⅷ.CHEMOTHERAPEUTIC DRUGS 754

43.Beta-Lactam Antibiotics ＆ Other Inhibitors of Cell Wall Synthesis&Henry F.Chambers,MD 754

44.Chloramphenicol, Tetracyclines, Macrolides, Clindamycin, ＆ Streptogramins&Henry F.Chambers, MD 774

45.Aminoglycosides ＆ Spectinomycin&Henry F.Chambers, MD 784

46.Sulfonamides, Trimethoprim, ＆ Quinolones&Henry F.Chambers, MD 793

47.AntimycobacterialDrugs&Henry F.Chambers,MD 803

48.AntifungalAgents&Don Sheppard, MD,＆ Harrry W.Lampiris, MD 814

49.AntiviralAgents&Sharon Safrin, MD 823

50.Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, ＆ Sterilants&Henry F.Chambers, MD 845

51.Clinical Use of Antimicrobial Agents&Harry W.Lampiris, MD, ＆ Daniel S.Maddix, PharmD 854

52.Basic Principles of Antiparasitic Chemotherapy&Ching Chung Wang, PhD 869

53.AntiprotozoalDrugs&Philip J.Rosenthal, MD, ＆ Robert S.Goldsmith, MD, DTM＆H 882

54.Clinical Pharmacology of the Anthelmintic Drugs&Robert S.Goldsmith, MD, DTM＆H 903

55.Cancer Chemotherapy&Sydney E.Salmon, MD, ＆ Alan C.Sartorelli, PhD 923

56.Immunopharmacology&Douglas F.Lake, PhD, Emmanuel T.Akporiaye, PhD, ＆ Evan M.Hersh, MD 959

Ⅸ.TOXICOLOGY 987

57.Introduction to Toxicology: Occupational ＆ Environmental&Gabriel L.Plaa, PhD 987

58.Heavy Metal Intoxication ＆ Chelators&Michael J.Kosnett, MD, MPH 999

59.Management of the Poisoned Patient&Kent R.Olson, MD 1011

Ⅹ.SPECIAL TOPICS 1025

60.Special Aspects of Perinatal ＆ Pediatric Pharmacology&Gideon Koren, MD 1025

61.Special Aspects of Geriatric Pharmacology&Bertram G.Katzung, MD, PhD 1036

62.Dermatologic Pharmacology&Dirk B.Robertson, MD, ＆ Howard I.Maibach, MD 1045

63.Drugs Used in Gastrointestinal Diseases&David F.Altman, MD 1064

64.Therapeutic ＆ Toxic Potential of Over-the-Counter Agents&Robin L.Corelli, PharmD, ＆ Mary Anne Koda-Kimble, PharmD 1077

65.Botanicals （“Herbal Medications”） ＆ Nutritional Supplements&Cathi E.Dennehy, PharmD, ＆ Candy Tsourounis, PharmD 1088

66.Rational Prescribing ＆ Prescription Writing&Paul W.Lofholm, PharmD, ＆ Bertram G.Katzung, MD, PhD 1104

Appendix Ⅰ.Vaccines, Immune Globulins, ＆ Other Complex Biologic Products&Harry W.Lampiris, MD, ＆ Daniel S.Maddix, PharmD 1113

Appendix Ⅱ.Important Drug Interactions ＆ Their Mechanisms&Philip D.Hansten, PharmD 1122

Index 1135