BASIC&CLINICAL PHARMACOLOGY TWELFTH EDITIONPDF电子书下载

SECTION I BASIC PRINCIPLES 1

1. Introduction&Bertram G. Katzung, MD, PhD 1

2. Drug Receptors & Pharmacodynamics&Mark von Zastrow, MD, PhD 15

3. Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action&Nicholas H. G. Holford, MB, ChB, FRACP 37

4. Drug Biotransformation&Maria Almira Correia, PhD 53

5. Development & Regulation of Drugs&Bertram G. Katzung, MD, PhD 69

SECTION Ⅱ AUTONOMIC DRUGS 79

6. Introduction to Autonomic Pharmacology&Bertram G. Katzung, MD, PhD 79

7. Cholinoceptor-Activating &Cholinesterase-Inhibiting Drugs&Achilles J. Pappano, PhD 97

8. Cholinoceptor-Blocking Drugs&Achilles J. Pappano, PhD 115

9. Adrenoceptor Agonists &Sympathomimetic Drugs&Italo Biaggioni, MD, & David Robertson, MD 129

10. Adrenoceptor Antagonist Drugs&David Robertson, MD, & Italo Biaggioni, MD 151

SECTION Ⅲ CARDIOVASCULAR-RENAL DRUGS 169

11. Antihypertensive Agents&Neal L. Benowitz, MD 169

12. Vasodilators & the Treatment of Angina Pectoris&Bertram G. Katzung, MD, PhD 193

13. Drugs Used in Heart Failure&Bertram G. Katzung, MD, PhD 211

14. Agents Used in Cardiac Arrhythmias&Joseph R. Hume, PhD, & Augustus O. Grant, MD, PhD 227

15. Diuretic Agents&Harlan E. Ives, MD, PhD 251

SECTION Ⅳ DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE 273

16. Histamine, Serotonin, & the Ergot Alkaloids&Bertram G. Katzung, MD, PhD 273

17. Vasoactive Peptides&Ian A. Reid, PhD 295

18. The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, &Related Compounds&Emer M. Smyth, PhD, & Garret A. FitzGerald, MD 313

19. Nitric Oxide&Samie R. Jaffrey, MD, PhD 331

20. Drugs Used in Asthma&Homer A. Boushey, MD 339

SECTION Ⅴ DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM 359

21. Introduction to the Pharmacology of CNS Drugs&Roger A. Nicoll, MD 359

22. Sedative-Hypnotic Drugs&Anthony J. Trevor, PhD, &Walter L. Way, MD 373

23. The Alcohols&Susan B. Masters, PhD 389

24. Antiseizure Drugs&Roger J. Porter, MD, &Brian S. Meldrum, MB, PhD 403

25. General Anesthetics&Helge Eilers, MD, & Spencer Yost, MD 429

26. Local Anesthetics&Kenneth Drasner, MD 449

27. Skeletal Muscle Relaxants&Marieke Kruidering-Hall, PhD, &Lundy Campbell, MD 465

28. Pharmacologic Management of Parkinsonism & Other Movement Disorders&Michael J. Aminoff, MD, DSc, FRCP 483

29. Antipsychotic Agents & Lithium&Herbert Meltzer, MD, PhD 501

30. Antidepressant Agents&Charles DeBattista, MD 521

31. Opioid Analgesics & Antagonists&Mark A. Schumacher, PhD, MD, Allan I. Basbaum, PhD, & Walter L. Way, MD 543

32. Drugs of Abuse&Christian Luscher, MD 565

SECTION Ⅵ DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, & GOUT 581

33. Agents Used in Anemias; Hematopoietic Growth Factors&Susan B. Masters, PhD 581

34. Drugs Used in Disorders of Coagulation&James L. Zehnder, MD 601

35. Agents Used in Dyslipidemia&Mary J. Malloy, MD, & John P. Kane, MD, PhD 619

36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout&Daniel E. Furst, MD, Robert W. Ulrich, PharmD, &Shraddha Prakash, MD 635

SECTION Ⅶ ENDOCRINE DRUGS 659

37. Hypothalamic & Pituitary Hormones&Susan B. Masters, PhD, & Stephen M.Rosenthal, MD 659

38. Thyroid & Antithyroid Drugs&Betty J. Dong, PharmD, FASHP, FCCP, & Francis S.Greenspan, MD, FACP 681

39. Adrenocorticosteroids & Adrenocortical Antagonists&George P. Chrousos, MD 697

40. The Gonadal Hormones & Inhibitors&George P. Chrousos, MD 715

41. Pancreatic Hormones & Antidiabetic Drugs&Martha S. Nolte Kennedy, MD 743

42. Agents That Affect Bone Mineral Homeostasis&Daniel D. Bikle, MD, PhD 769

SECTION Ⅷ CHEMOTHERAPEUTIC DRUGS 789

43. Beta-Lactam & Other Cell Wall- &Membrane-Active Antibiotics&Daniel H. Deck, PharmD, &Lisa G. Winston, MD 790

44. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins,& Oxazolidinones&Daniel H. Deck, PharmD, &Lisa G. Winston, MD 809

45. Aminoglycosides & Spectinomycin&Daniel H. Deck, PharmD, &Lisa G. Winston, MD 821

46. Sulfonamides, Trimethoprim, & Quinolones&Daniel H. Deck, PharmD, &Lisa G. Winston, MD 831

47. Antimycobacterial Drugs&Daniel H. Deck, PharmD, &Lisa G. Winston, MD 839

48. Antifungal Agents&Don Sheppard, MD, &Harry W. Lampiris, MD 849

49. Antiviral Agents&Sharon Safrin, MD 861

50. Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, & Sterilants&Daniel H. Deck, PharmD, &Lisa G. Winston, MD 891

51. Clinical Use of Antimicrobial Agents&Harry W. Lampiris, MD, & Daniel S. Maddix,PharmD 901

52. Antiprotozoal Drugs&Philip J. Rosenthal, MD 915

53. Clinical Pharmacology of the Antihelminthic Drugs&Philip J. Rosenthal, MD 937

54. Cancer Chemotherapy&Edward Chu, MD, &Alan C. Sartorelli, PhD 949

55. Immunopharmacology&Douglas F. Lake, PhD, Adrienne D. Briggs, MD, &Emmanuel T. Akporiaye, PhD 977

SECTION Ⅸ TOXICOLOGY 1001

56. Introduction to Toxicology: Occupational& Environmental&Daniel T. Teitelbaum, MD 1001

57. Heavy Metal Intoxication & Chelators&Michael J. Kosnett, MD, MPH 1013

58. Management of the Poisoned Patient&Kent R. Olson, MD 1027

SECTION Ⅹ SPECIAL TOPICS 1039

59. Special Aspects of Perinatal &Pediatric Pharmacology&Gideon Koren, MD 1039

60. Special Aspects of Geriatric Pharmacology&Bertram G. Katzung, MD, PhD 1051

61. Dermatologic Pharmacology&Dirk B. Robertson, MD, &Howard L Maibach, MD 1061

62. Drugs Used in the Treatment of Gastrointestinal Diseases&Kenneth R. McQuaid, MD 1081

63. Therapeutic & Toxic Potential of Over-the-Counter Agents&Robin L. Corelli, PharmD 1115

64. Dietary Supplements & Herbal Medications&Cathi E. Dennehy, PharmD, & Candy Tsourounis, PharmD 1125

65. Rational Prescribing & Prescription Writing&Paul W. Lofholm, PharmD, &Bertram G. Katzung, MD, PhD 1139

66. Important Drug Interactions &Their Mechanisms&John R. Horn, PharmD, FCCP 1149

Appendix: Vaccines, Immune Globulins, & Other Complex Biologic Products&Harry W. Lampiris, MD, & Daniel S. Maddix, PharmD 1163

Index 1171