医学免疫学 留学生与双语教学用 英文原版改编版PDF电子书下载

Chapter 1 Introduction 1

A BRIEF OVERVIEW OF IMMUNOLOGY 1

HISTORY OF IMMUNOLOGY 10

STUDY QUESTIONS 13

SUGGESTED READINGS 13

Chapter 2 Antigen 14

DEFINITION 14

EPITOPES 14

CLASSIFICATION OF ANTIGENS BASED ON IMMUN RESPONSE 15

DETERMINANTS OF IMMUNOGENICITY 15

ANTIGEN RECEPTORS 16

ANTIGENIC SPECIFICITY 17

STUDY QUESTIONS 18

SUGGESTED READINGS 18

Chapter 3 Antigen Recognition Molecules 19

ANTIBODIES-IMMUNOGLOBULINS 20

MAJOR HISTOCOMPATIBILITY COMPLEX 25

STUDY QUESTIONS 28

SUGGESTED READINGS 28

Chapter 4 The Complement System 29

COMPLEMENT ACTIVATION 29

REGULATION OF THE COMPLEMENT SYSTEM 31

BIOLOGICAL CONSEQUENCES OF COMPLEMENT ACTIVATION 32

DEFECTS IN THE COMPLEMENT SYSTEM 34

STUDY QUESTIONS 34

SUGGESTED READINGS 35

Chapter 5 Organs and Tissues of the Immune System 36

LYMPHOID ORGANS 36

STUDY QUESTIONS 39

SUGGESTED READINGS 39

Chapter 6 Immune Cells 41

LYMPHOCYTES 41

PHAGOCYTIC CELLS 47

DENDRITIC CELLS 48

STUDY QUESTIONS 48

SUGGESTED READINGS 48

Chapter 7 Immune Response 49

ANTIGEN PROCESSING AND PRESENTATION 49

ACTIVATION OF HELPER T LYMPHOCYTES 51

HUMORAL IMMUNE RESPONSE(HUMORAL IMMUNITY) 55

PRIMARY AND SECONDARY RESPONSE 58

FACTORS INFLUENCING ANTIBODY PRODUCTION 59

CELL-MEDIATED IMMUNE RESPONSE(CELL-MEDIATED IMMUNITY) 60

CYTOKINES 64

THEORIES OF IMMUNE RESPONSE 71

STUDY QUESTIONS 73

SUGGESTED READINGS 75

Chapter 8 Immunological Tolerance 76

CENTRAL T CELL TOLERANCE TO SELF-ANTIGENS 76

PERIPHERAL T CELL TOLERANCE TO SELF-ANTIGENS 77

B CELL TOLERANCE TO SELF-ANTIGENS 78

ARTIFICIALLY INDUCED TOLERANCE IN VIVO 79

STUDY QUESTIONS 80

SUGGESTED READINGS 80

Chapter 9 Hypersensitivity 81

DEFINITION 81

GELL AND COOMBS CLASSIFICATION 81

IMMEDIATE TYPE I HYPERSENSITIVITY 81

TYPE Ⅱ HYPERSENSITIVITY REACTION(ANTIBODY-DEPENDENT CYTOTOXICITY) 89

TYPE Ⅲ HYPERSENSITIVITY REACTION(IMMUNE COMPLEX-MEDIATED) 93

TYPE Ⅳ CELL-MEDIATED (DELAYED)HYPERSENSITIVITY 96

STUDY QUESTIONS 101

SUGGESTED READINGS 101

Chapter 10 Autoimmuni 102

PROBABLE MECHANISMS OF AUTOIMMUNITY 102

AUTOIMMUNE DISEASES 107

STUDY QUESTIONS 109

SUGGESTED READINGS 110

Chapter 11 Immunodeficiency Disorders 111

PRIMARY IMMUNODEFICIENCIES 111

SECONDARY(ACQUIRED)IMMUNODEFICIENCIES 117

STUDY QUESTIONS 125

SUGGESTED READINGS 125

Chapter 12 Tumor Immunology 126

CANCER:ORIGIN 126

TUMOR ANTIGENS 129

CANCER IMMUNOTHERAPY 134

STUDY QUESTIONS 136

SUGGESTED READINGS 137

Chapter 13 Transplantation Immunology 138

GRAFT REJECTION 138

FACTORS FAVORINGALLOGRAFT SURVIVAL 140

MECHANISM INVOLVED IN GRAFT REJECTION 142

TEMPO OF REJECTION 145

STUDY QUESTIONS 147

SUGGESTED READINGS 147

Chapter 14 Immunological Techniques 149

STAGES OF ANTIGEN-ANTIBODY INTERACTIONS 149

MEASUREMENT OF ANTIGEN AND ANTIBODY 149

PRECIPITATIONREACTIONS 149

AGGLUTINATION REACTION 154

MONOCLONAL ANTIBODIES AND HYBRIDOMA TECHNIQUE 167

STUDY QUESTIONS 170

SUGGESTED READINGS 171

Chapter 15 Immunoprophylaxis ＆ Immunotherapy 172

IMMMUNOPROPHYLAXIS 172

IMMUNOTHERAPY 179

STUDY QUESTIONS 183

SUGGESTED READINGS 183

Chapter 16 Immunity in Viral,Bacterial,Fungal,and Parasitic Infections 184

IMMUNITY IN VIRALINFECTIONS 184

IMMUNITY IN BACTERIAL INFECTIONS 188

IMMUNITY IN FUNGAL INFECTIONS 197

IMMUNITY IN PARASITIC INFECTIONS 198

STUDY QUESTIONS 204

SUGGESTED READINGS 204