发育神经生物学PDF电子书下载

第一章 机体发育过程中的基因表达及同源异形基因盒 1

Chapter 1 Expression of Genes during Development and Homebox Gene 1

Differentiation of Embryonic Cell 2

胚胎细胞分化 2

Expression of Genes during Development 5

机体成形过程中的基因表达 5

Specific Expression of Genes in Adult Tissue 18

成体组织中基因的特异性表达 18

Modulation of Genes in Cell Differentiation 19

细胞分化的基因调控机制 19

Homebox Gene and Developing Nervous System 21

同源盒基因家族与神经系统发育 21

第二章 神经细胞的发育分化与神经系统发育中的基因调控 32

Chapter 2 Development and Differentiation of Neural Cells and Modulation of Genes in Developing Nerv 32

Neuroepitheliurn in Cell Circle 32

细胞周期中的神经上皮细胞 32

中枢神经系统神经元与神经胶质细胞的起源与分化 37

Origin and Differentiation of Neuron and Neuroglia in Central Nervous System 37

Modulation of Genes in Developing Nervous System 47

神经系统发育中的基因调控 47

胚盘中轴结构的形成 52

Formation of Axonal Structure in Embryonic Disk 52

Chapter 3 Development of Nervous System 52

第三章 神经系统的发生 52

Developmental Model of Developing Nervous System 53

神经系统发育分化的基本规律和模式 53

神经诱导与分化决定 54

Neural Indution and Determination 54

细胞粘附分子与神经发育 58

Neural Cell Adhesion Molecule and Neural Development 58

Morphogenesis of Nervous System 60

神经系统的发生 60

Chapter 4 Axonal Development 76

第四章 轴突的发育 76

细胞骨架 77

The Cytoskeleton 77

轴突运输 83

Axonal Transport 83

生长锥 86

The Growth Cone 86

Outgrowth of the Axon 89

轴突的长出 89

Single Transduction during Axonal Growth 95

轴突生长发育过程中的信息转导 95

Chapter 5 Dendritic Development and Formation of Synaptic Connections 98

第五章 树突的发育和突触的形成 98

Outgrowth of Dendrite 99

树突的生长发育 99

树突发育的时空规律 101

Time and Spatial Regulation of Developing Dendrite 101

Morphology of Dendritic Growth Cone 102

Morphology and Function of Dendritic Spine 102

树突生长锥的形态结构 102

树突棘的结构和功能 102

Cytochrome Oxidase Activity of Dendrite 105

树突的细胞色素氧化酶活性 105

Factors Influencing Growth of Dendrite 106

影响树突生长发育的一些因素 106

树突发育的稳定性 108

Developmental Stability of Dendrite 108

突触形成的一般概述 109

Introduction of Synaptic Formation 109

Program of Synaptic Formation 111

突触形成的程序性 111

Ultrastructural Defferentiation of Synapses 113

突触超微结构的分化 113

突触连接的地域分布特异性 115

突触的稳定性和适应性 115

Synaptic Stability and Lability 115

Topographical Specificity of Synaptic Connection 115

视觉刺激和视觉剥夺对突触形成的影响 116

Effects of Visual Stimultion and Deprivation on Formation of Synaptic Connection 116

蛋白质聚集素在突触形成中的作用 117

Role of Argine in Synapse Formation 117

概论 120

第六章 神经嵴及其衍生物 120

Introduction 120

Chapter 6 The Neural Crest and Its Derivatives 120

Developmental Process of Nreural Crest 124

神经嵴的发育过程 124

Basic Patterns of Neural Crest Development 133

神经嵴发育的基本方式 133

Factors Regulating Development and Differentiation of Neural Crest and Its Derivatives 134

神经嵴及其衍生物分化发育的调控因素 134

Regulating Model of Migration of Neural Crest Cells 136

神经嵴细胞迁移的调节模式 136

Control of Differentiation of Neural Crest Cells 137

神经嵴细胞分化的调控 137

脊髓感觉通路的胚胎发生及调控因素 138

Histogenesis of Spinal Sensory Pathway and Its Regulating Factors 138

Chapter 7 Neuroglial Cells 142

第七章 神经胶质细胞 142

Origin and Differentiation of CNS Macroglial Cells 144

中枢大胶质细胞的起源和分化 144

Astrocytes 145

星形胶质细胞 145

少突胶质细胞 156

Oligodendrocytes 156

小胶质细胞 163

Microglial Cells 163

Chapter 8 Histogenesis of Cerebral Neocortex 171

Schwann Cells 171

雪旺细胞 171

第八章 大脑新皮质的组织发生 177

Development of Cerebral Cortex:Overview 177

大脑皮质发育概况 177

Developmental Pattem of Ancestor Cells in Ventricular Zone of Telencephalon 178

端脑脑室层祖细胞的发生规律 178

Formation of the Cortical Preplate 181

早期胚胎皮质板的发生 181

大脑新皮质板层的组织发生 185

Histogenesis of Cerebral Cortical Plate 185

大脑皮质传入神经纤维的发生 188

Development of Cerebral Cortical Afferent Nerve Fibers 188

大脑皮质传出神经纤维的发生 191

Development of Cerebral Cortical Efferent Nerve Fibers 191

大脑皮质功能单位的发育 192

Development of Functional Units in Cerebral Cortex 192

视皮质神经回路的发生 196

Histogenesis of Neural-Circuit in the Optic Tecturn 196

General Overview of Retinal Canglion Cells 201

第九章 视网膜节细胞发育 201

视网膜节细胞概况 201

Chapter 9 Development of Retinal Ganglion Cells 201

视网膜节细胞的密度和分布 202

Density and Distribution of Retinal Ganglion Cells 202

视网膜节细胞的分类 203

Classification of Retinal Ganglion Cells 203

Arrangement of Dendrites of Retinal Ganglion Cells 208

视网膜节细胞树突的分层 208

视网膜节细胞的分化和发育 208

Development and Differentiation of Retinal Ganglion Cells 208

视网膜节细胞轴突投射的发育 212

Development of Axon Projections of Retinal Ganglion Cells 212

历史回顾 221

Historical Overview 221

Chapter 10 Programmed Neuronal Death and Its Occurring Mechanisms during Development 221

第十章 发育过程中的神经细胞编程性死亡及其发生机理 221

细胞凋亡的形态学与生化特征 222

Morpbological and Biochemical Characteristics of Cell Apoptosis 222

神经细胞编程性死亡的生物学意义 227

Biological Significance of Programmed Neuronal Death 227

神经细胞编程性死亡的发生机理 229

Occurring Mechanisms of Programmed Neuronal Death 229

细胞周期与细胞凋亡 238

Cell Cycle and Cell Apoptosis 238

老化与发育：对立的统一 243

Aging and Development;Opposite Unity 243

第十一章 脑的老化与老年性痴呆 243

Chapter 11 Brain Aging and Senile Dementia 243

脑的老化 246

Aging of Brain 246

生理性脑老化与老年性痴呆 250

Physiological Aging of Brain and Dementia 250

推迟脑衰老的对策 253

Counter Tactics of Postpone the Aging of Brain 253

Chapter 12 Neurotrophic Factors 259

第十二章 神经营养因子 259

The Family of Neurotrophic Factors 260

神经营养素家族 260

Ciliar Neurotrophic Factors 269

睫状神经营养因子 269

Astroglia-Derived Neuropholic Factors 272

胶质细胞系源性神经营养因子 272

已知的生长因子和细胞因子 273

Known Growth Factors and Cytokines 273

Neurotrophic Factors and Neural Degenerative Disease 279

神经营养因子与神经变性疾病 279

第十三章 中枢神经系统的可塑性 284

Chapter 13 Plasticity of Central Nervous System 284

视神经的可塑性 285

Plasticity of Optic Nerve 285

Plasticity of Spinal Cord 297

脊髓的可塑性 297

Chapter 14 Dependence of the Developing Nervous System on Nutrition and Hormones and Related Questio 304

第十四章 神经系统发育对激素与营养的依赖性及其他有关问题 304

Dependence of the Developing Nervous System on Nutrition and Hormones 305

神经系统发育对激素与营养的依赖性 305

Nitric Oxide and the Development and Regeneration of Nervous System 314

NO与神经系统的发育及再生 314

Transmitter Development of Neurons in Central Nervous System 325

中枢神经元的递质发育 325

学习、记忆与脑发育 336

Learning, Memory and Brain Development 336

Chapter 15 Transplantation and the Development and Regeneration of Central Nervous System 348

第十五章 脑内移植与中枢神经系统的发育再生 348

脑内移植研究的历史及现状 349

Historical Orientation of Transplantation 349

Functional Mechanisms of Transplantation 350

脑内移植物产生功能效应的机理 350

Transplantation of Nerve Tissue and the Development and Regeneration of Central Nervous System 353

神经组织移植与中枢神经发育再生 353

Recovery of Central Nervous Degenerative Disease by Transplantation of Nerve Tissue 356

神经组织移植修复中枢神经退行性疾病的研究 356

Chapter 16 Developing Nervous System and Tumor 370

第十六章 神经系统发育与肿瘤 370

Similarity of Fetus Development and Tumorgenesis 371

胚胎发育与肿瘤的相似性 371

Etiology and Etiopathogeneis Mechanism of Tumor 374

肿瘤的病因及致癌机理 374

Oncogene, Anti-Oncogene and Tumorgenesis 376

癌基因、抑癌基因与肿瘤发生 376

Sort and Physiological Function of Oncogene 378

癌基因的种类及生理功能 378

Oncogenes Related to the Development and Differention of Nervous System 380

与神经系统分化发育有关的癌基因 380

Genetic Tumor of the Centeral Nervous System Retinal Blastoma 381

神经系统遗传性肿瘤视网膜母细胞瘤 381

Other Tumors Related Fetus Development 382

神经系统其他的与胚胎发生有关的肿瘤 382

Introduction 384

Chapter 17 Methodology of Studying Tissue Development and Differentiation 384

第十七章 研究组织发育分化的一些实验技术 384

概述 384

Culture of Mouse Fetus after Transplantation 385

植入后小鼠胚胎的培养 385

Culture of Neural Plate, Crest, and Neural Tuble 390

神经板、神经嵴和神经管的培养 390

Subrenal Capsule Embryo Heterotopic Transplantation 392

肾被膜下间隙胚胎异位移植技术 392

Eye Anterior Heterotopic Transplantation 393

眼前房胚胎异位移植技术 393