吴冠芸教授论文选 3
1．大肠杆菌可溶性核糖核酸的提取及其性质的研究 3
2．靛玉红治疗慢性粒细胞白血病疗效原理的研究——靛玉红与DNA的结合作用及其结合键型的鉴别 10
3．α-地中海贫血的早期产前基因诊断 17
4．广西地区19例HbH病人的α-珠蛋白基因组织 21
5．甲型血友病基因诊断的研究 28
6．中国广西、广东、四川三省区β-地中海贫血基因突变类型及产前基因诊断研究 33
7．安徽省铜陵市脆性X综合征的分子生物学调查和遗传学分析 38
8．Application of capillary nongel sieving electrophoresis for gene analysis 42
吴冠芸教授发表的论文和著作目录 53
论文目录 53
综述与译文目录 67
书籍目录 68
祝贺吴冠芸教授80华诞 71
著名生物化学与分子生物学家吴冠芸教授 71
我的导师吴冠芸教授&杨善蓉 74
祝贺论文选（以作者姓氏拼音为序） 75
1．RanBPM is a novel binding protein for p75NTR&Dong Bai,Bing-Ren Huang（黄秉仁）et al 75
2．Transgenic study of the function of chymase in heart remodeling&Lan-Ying Chen（陈兰英）et al 83
3．Hb F-Forest Park,a new Aγ variant with two amino acid substitutions,75(E19)Ile→Thr and 73(E17)Asp→Asn,which can be identified in adults by gene-mapping analysis&Song-sen Chen（陈松森）et al 97
4．High-level expression of foreign genes via multiple joined operons and a new concept regarding the restricted constant of total amount of plasmid DNA per Escherichia coli cell&Chen Weijing、Lu Shengdong（卢圣栋）et al 105
5．Association between Genetic Variation of CACNA1H and Childhood Absence Epilepsy&Yucai Chen,Yan Shen（沈岩）et al 112
6．The expression of human α-like globin genes in transgenic mice mediated by bacterial artificial chromosome&Dong-Xiao、Chih-Chuan Liang（梁植权）et al 119
7．Correlation of expression of BP1,a homeobox gene,with estrogen receptor status in breast cancer&Sidney W Fu（付四东）et al 127
8．Distinct functions of two isoforms of a homeobox gene,BP1 and DLX7,in the regulation of the β-globin gene&Sidong Fu（付四东）et al 136
9．Effects of point mutation C→T at-64 of human δ globin gene promoter on DNA binding proteins&Kou Haiping、Liang Zhiquan（梁植权）et al 148
10．The effect of chemical carcinogenesis on rat glutathione S-transferase PI gene transcriptional regulation&Dongyuan Liu、Fude Fang（方福德）et al 154
11．Heterogeneity of Adult Polycystic Kidney Disease Analysis of an APKD Family Unlinked to 3'HVR&LIU Guo-Yang（刘国仰）et al 163
12．A CASE OF HEMOGLOBIN IWATA[α87(F8)HIS→ARG]IN CHINA&Liu Guoyang（刘国仰）et al 167
13．PCR assay for the inversion causing severe Hemophilia A and its application&Liu Jingzhong（刘敬忠）et al 170
14．STUDIES OF β-THALASSEMIA MUTATIONS IN FAMILIES LIVING IN THREE PROVINCES IN SOUTHERN CHINA&J.Z.Liu（刘敬忠）et al 177
15．多基因疾病相关基因定位的研究策略&刘天承、邱长春等 184
16．Tyrosine mutation in CD3ε-ITAM Blocked T Lymphocyte Apoptosis Mediated by CD3ε&Yanxin Liu、Dexian Zheng（郑德先）et al 192
17．Deficiency of the Mouse Complement Regulatory Protein mCd59b Results in Spontaneous Hemolytic Anemia with Platelet Activation and Progressive Male Infertility&Xuebin Qin（秦学斌）et al 202
18．重组可溶性TRAIL的表达与生物学活性&史娟、刘士廉、刘彦信、郑德先等 218
19．Multiplex Allele-specific Polymerase Chain Reaction in the Diagnosis of Phenylketonuria&SONG Fang（宋昉）et al 223
20．中国人苯丙氨酸羟化酶基因的10种新突变&宋昉等 227
21．Detection of Erythrocytes Deficient of Glycosylphosphatidylinositol Anchored Membrane proteins in patients with Paroxysmal Nocturnal Hemoglobinuria by the toxin HEC secreted by Aeromonas hydrophila J-1&Jian Wang、Caimin Xu（许彩民）、Huazhen Pan（潘华珍）、Zhinan Zhang（张之南）et al 232
22．苯丙酮尿症患者苯丙氨酸羟化酶基因的两个新突变&徐陆亭、苗世荣、刘国仰、黄尚志、罗会元等 239
23．Overexpression and purification of recombinant atrial natriuretic peptide using hybrid fusion protein REF-ANP in Escherichia coli&Jun Wang、Shengdong Lu（卢圣栋）et al 243
24．ASH2L:alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell line&Yan Shen（沈岩）、Jiangang Yuan（袁建刚）、Boqin Qiang（强伯勤）、Junhua Wang et al 254
25．人干细胞因子受体c-Kit稳定表达细胞株的构建&熊安琪、陈松森等 264
26．PKC∈ Is a Unique Regulator for hsp90β Gene in Heat Shock Response&Jianmin Wu、Lian-xian Cui（崔莲仙）、Ninghua Wu（吴宁华）、Yufei Shen（沈羽非）et al 270
27．Mekk3 is essential for early embryonic cardiovascular development&Jianhua Yang（杨建华）et al 282
28．Calcineurin/Nuclear Factors of Activated T Cells(NFAT)-activating and Immunoreceptor Tyrosine-based Activation Motif(ITAM)-containing Protein(CNAIP),a Novel ITAM-containing protein That Activates the Calcineurin/NFAT-signaling pathway&Jianhua Yang（杨建华）et al 291
29．The essential role of MEKK3 in TNF-induced NF-κB activation&Jianhua Yang（杨建华）et al 301
30．Molecular Characterization of a Novel form of(Aγδβ)0 Thalassemia Deletion in a Chinese Family&JunWu Zhang（张俊武）et al 310
31．A novel gene,RSD-3/HSD-3.1,encodes a meiotic-related protein expressed in rat and human testis&Xiaodong Zhang、Shiying Miao（缪时英）、Linfang Wang（王琳芳）et al 319
32．DSPP mutation in dentinogenesis imperfecta Shields typeⅡ&Xiaohai Zhang、Boqin Zhang（强伯勤）、Yan Shen（沈岩）et al 332
33．The 3'breakpoint of the Yunnanese(Aγδβ)0-thalassemia deletion lies in an L1 family sequence:implications for the mechanism of deletion and the reactivation of the Gγ-globin gene&Xue-Qing Zhang ＆ Jun-Wu Zhang（张俊武） 336
34．原发性高血压相关新基因的发现——D1S249位点与汉族EH相关联&郑勇、邱长春等 345
35．Inhibition of L ZIP-mediated Transcription through Direct Interaction with a Novel Host Cell Factor-Like Protein&HaiJun Zhou、BoQin Qiang（强伯勤）、JianGang Yuan（袁建刚）et al 352
36．Fudenine,a C-Terminal Truncated Rat Homologue of Mouse prominin,Is Blood Glucose-Regulated and Can Up-Regulate the Expression of GAPDH&Guozhi Zhu、Jin Zuo（左瑾）、Fude Fang（方福德）et al 364
37．Cloning and characterization of PIMT,a protein with a methyltransferase domain,which interacts with and enhances nuclear receptor coactivator PRIP function&Yijun Zhu（朱益军）et al 373
38．Coactivator PRIP,the Peroxisome Proliferator-activated Receptor-interacting Protein,Is a Modulator of Placental,Cardiac,Hepatic,and Embryonic Development&Yi-Jun Zhu（朱益军）et al 385
编后记 395