Chapter 1 INTRODUCTION 15
Historical Background 15
The Concept of Allergy 16
Allergy as an Antigen-Antibody Reaction 19
Terminology 20
Chapter 2 IMMUNOLOGY OF ALLERGIC DISEASES 23
Anaphylaxis 23
Atopic Sensitization 27
Contact Dermatitis 28
Delayed Bacterial Hypersensitivity 29
Classification of Allergic Reactions 30
Chapter 3 NONIMMUNOLOGIC FACTORS AFFECTING ALLERGIC REACTIONS 32
Chemical Factors 32
Hormones 33
The Autonomic Nervous System 35
Effect of Physiologic Activity of the Shock Organ 37
Effect of Nonspecific Irritants on the Shock Organ 37
Influence of Emotionah Factors 37
Chapter 4 DRUGS USED IN THE TREATMENT OF ALLERGY 41
Antihistamine Drugs 41
Preparations 44
Adrenergic Drugs 45
Epinephrine 45
Ephedrine 46
Isopropylarterenol 47
Phenylephrine Hydrochloride(Neo-Synephrine)and Naphazoline Hydrochloride(Privine) 47
Cortisone and Related Compounds 48
Chapter 5 ANAPHYLAXIS IN PEDIATRIC PRACTICE 51
Etiology 51
Anaphylactic Shock 52
Physiology 52
Symptoms 52
Diagnosis 53
Treatment 53
Allergic Reactions to Insect Stings and Bites 53
Etiology 54
Symptoms 54
Treatment 54
Prognosis 55
Biting Insects 55
Sensitization to Parasitic Worms 56
Etiology 56
Diagnostic Skin and Serologic Tests 56
Allergic Manifestations 56
Loeffler＇s Syndrome 57
Etiology 57
Symptoms 58
Diagnosis 60
Treatment 60
Chapter 6 SERUM SICKNESS AND SERUM REACTIONS 61
Serum Sickness 61
Etiology 61
Immunologic Mechanism 62
Symptoms 62
Pathology 64
Diagnosis 64
Treatment 64
Prognosis 65
Immediate Reactions to Heterologous Serum 65
Immunology 65
Diagnosis of Serum Sensitization 66
Administration of Antiserum to Sensitive Children 66
Symptoms and Treatment of Immediate Shock Reactions 68
Accelerated Serum Reactions 68
Symptoms 69
Prevention and Treatment 69
Arthus Reactions to Antisera 69
Clinical Features 69
Prevention and Treatment 70
Use of Toxoids 70
Chapter 7 THE ATOPIC DISEASES 72
Clinical Association of Diseases of the Group 72
Heredity 73
Effect of Exposure to Allergens 75
Natural History of Atopic Disease 77
The Immediate Urticarial Skin Reaction 78
Skin-Sensitizing Antibodies 80
Immunologic Effects of Injections of Antigen 81
Physiology of Atopic Reactions 83
The Constitutional Reaction 84
Etiology 85
Symptoms 85
Treatment 86
Chapter 8 ALLERGENS CAUSING ATOPIC DISEASES 88
Inhalant Allergens 88
Pollen Allergens 95
Food Allergens 101
Antigenic Solutions for Testing and Treatment 107
Chapter 9 DIAGNOSIS OF THE SPECIFIC CAUSATIVE ALLERGENS 111
Clinical History 112
Skin Tests 114
The Scratch Test 116
The Intracutaneous Test 117
Nonallergic Factors Affecting Skin Tests 119
Intracutaneous Tests With Bacterial Antigens 119
Passive Transfer Tests 120
Significance of Skin Tests 124
Mucosa Tests 126
Correlation of Skin Reactions and History 127
Dietary Trials 129
Environmental Tests 130
General Principles 131
Chapter 10 INJECTION TREATMENT 133
General Principles 133
Indication for Injection Treatment 134
Results 134
Technique and Necessary Precautions 135
Dosage 135
Maintenance Treatment 138
Constitutional Reactions 139
Mixture of Antigens 141
Desensitization With Food Antigens 143
Injection Treatment With Bacterial Antigens 143
Chapter 11 ALLERGIC RHINITIS 146
Terminology 146
Incidence 146
Etiology 147
Pathology and Physiology 147
Symptoms and Diagnosis 148
Treatment 154
Prognosis and Complications 157
Relation of Allergic Rhinitis to Upper Respiratory Infection 158
Chapter 12 BRONCHIAL ASTHMA 161
Pathology 161
Physiology 162
Symptoms 165
Differential Diagnosis 166
Etiologic Diagnosis 168
Symptomatic Treatment 173
Useful Drugs 173
Home Treatment 176
Treatment Administered by Physician 177
Hospital Treatment 177
Specific Treatment 178
Treatment of Infection 180
Emotional Factors 182
General Measures 183
Prognosis and Complications 186
Chapter 13 ATOPIC DERMATITIS-INFANTILE ECZEMA 190
Etiology 190
Symptoms and Pathology 194
Differential Diagnosis 196
Etiologic Diagnosis 197
Specific Treatment 201
Symptomatic Treatment 203
Prognosis and Complications 206
Chapter 14 URTICARIA AND ANGIOEDEMA 208
Urticaria 208
Etiology 208
Physiology and Pathology 210
Symptoms 210
Diagnosis 211
Treatment 212
Prognosis 213
Angioedema(Giant Urticaria) 214
Symptoms 214
Diagnosis 214
Treatment 214
Chapter 15 GASTROINTESTINAL ALLERGY 215
Etiology 215
Physiology 215
Symptoms 216
Diagnosis 217
Treatment 218
Chapter 16 ALLERGY OF THE EYE 219
Allergic Conjunctivitis 219
Atopic Conjunctivitis 219
Dermato-conjunctivitis 220
Conjunctivitis Due to Bacterial Allergy 220
Vernal Conjunctivitis 221
Etiology 221
Symptoms 221
Etiologic Diagnosis 222
Treatment 222
Phlyctenular Keratoconjunctivitis 223
Other Allergic Diseases of the Eye 223
Uveitis 223
Sympathetic Ophthalmia 224
Endophthalmitis Phacoanaphylactica 224
Cataract Associated With Atopic Dermatitis 224
Chapter 17 ALLERGY OF THE CENTRAL NERVOUS SYSTEM 225
Headache-Migraine 226
Epilepsy 228
Behavior Disorders 229
Chapter 18 CONTACT DERMATITIS 231
Terminology 231
Etiology 232
Immunology and Pathology 234
Diagnosis 235
Prophylaxis and Treatment 237
Prognosis and Complications 240
Chapter 19 DELAYED ALLERGY TO INFECTIVE AGENTS 242
Types of Allergic Reactions to Infection 242
Organisms Inducing Delayed Allergy 243
Nature of the Delayed Reactions 244
Effect of Bacterial Allergy on Pathogenesis of Infectious Diseases 244
Relation of Bacterial Allergy to Immunity 244
Desensitization 245
Diagnostic Skin Tests Dependent on Delayed Allergy 245
Chapter 20 ALLERGIC PURPURA 248
Nature of Purpura 248
Types of Purpura 249
Anaphylactoid Purpura 249
Etiology 249
Symptoms 250
Diagnosis 250
Treatment 251
Prognosis 251
Idiopathic Thrombocytopenic Purpura 251
Purpura Due to Drugs 252
Chapter 21 DRUG ALLERGY 253
Special Features of Drug Allergy 253
Urticaria and Angioedema 254
Reactions Resembling Serum Sickness 255
Anaphylactic Reactions 255
General Atopic Reactions 256
Drug Fever 256
Drug Rashes 257
Hepatitis 258
Blood Dyscrasias 259
Specificity and Duration of Drug Allergy 260
Desensitization 260
Suppression of Drug Allergy by Other Medications 260
Chapter 22 PHYSICAL ALLERGY 262
Cold Urticaria 264
Heat Urticaria 265
Allergy to Light 266
Urticaria Due to Mechanical Irritation 266
Chapter 23 ALLERGY IN RELATION TO COLLAGEN DISEASES 268
Rheumatic Fever 269
Etiologic Factors 269
Clinical Evidence of an Allergic Factor 270
Pathologic Evidence 270
Rheumatoid Arthritis 271
Periarteritis Nodosa 271
Disseminated Lupus Erythematosus 272
Scleroderma and Dermatomyositis 273
Chapter 24 GENERAL PEDIATRIC CARE OF THE ALLERGIC CHILD 274
Characteristics of the Allergic Child 274
General Principles 274
Diet 275
Diet of Mother During Pregnancy 277
Furnishings 277
Pets 278
Exercise 278
Respiratory Infections 279
Emotional Problems 279
Immunizations 279
APPENDIX 281
Measures for the Control of House Dust 281
Lists of Allergen Extracts for Testing 283
Inhalants 283
Molds 284
Foods 284
Miscellaneous 285
Pollens 285
Other Methods of Standardization 285
Group Antigens 285
Dilution of Extracts 286
Preparation of Dust Extract 286
Sterilization by Filtration 287
Sterility Tests 288