PART Ⅰ－GENERAL PHYSICOCHEMICAL AND PHYSIOLOGIC CONSIDERATIONS OF HYPOTHERMIA 1
Some Considerations of Physicochemical Factors in Hypothermia＆D．E．S．Brown 1
Effects of Hypothermia on General Metabolism＆S．M．Horvath and G．B．Spurr 8
The Effect of Low Temperatures upon Intracellular Potassium in Isolated Tissues＆I．M．Taylor 26
Potassium Exchange in Perfused Mammalian Skeletal Muscle＆E．M．Renkin 32
Electrolyte Transfer during Hypothermia＆Frank Gollan 37
Myocardial Balance of Potassium＆Henry Swan 42
Effects of Low Body Temperature on Tissue Oxygen Utilization＆E．F．Adolph 44
Oxygen Consumption of Mammalian Tissue at Reduced Temperatures＆F．A．Fuhrman 50
Respiratory Physiologic Studies During Hypothermia＆J．W．Severinghaus and M．Stupfei 52
The Gas Transport System in Hypothermia＆F．F．Kao 58
Hypothermia in the Unanesthetized Poikilothermic Dog＆A．D．Keller 61
Discussion：＆A．C．Burton，J．W．Severinghaus，and J．Cahn 78
Physiology of Hibernation in Mammals＆C．P．Lyman and P．O．Chat field 80
Discussion：＆A．C．Burton，A．D．Keller；E．Calkins，G．E．Burch，J．D．McMurrey，H．Swan，C．McC．Brooks，and R．K．Andjus 122
Resuscitation and Recovery of Hypothermic，Supercooled，and Frozen Mammals＆R．K．Andjus，J．E．Lovelock，and A．U．Smith 125
Discussion：＆F．J．Lewis，J．W．Severinghaus，W．Parkins，A．L．Hopkins，J．Fine，R．W．Brauer，F．D．Moore，R．D．Dripps，and J．Henley 143
PART Ⅱ－THE EFFECTS OF HYPOTHERMIA ON SPECIFIC SYSTEMS 146
Cardiovascular Functions in Deep Hypothermia＆H．E D＇Amato 146
Discussion：＆I．K．R．McMillan and E．Friedman 155
The Circulation During Rewarming＆Henry Swan 161
Discussion：＆R．O．Heimbecker and J．Fine 161
Coronary Blood Flow During Hypothermia＆R．M．Berne 165
The Effect of Hypothermia on Pituitary ACTH Release and on Adrenal Cortical and Medullary Secretion in the Dog＆D．M．Hume，R．H．Egdahl，and D．H．Nelson 170
Discussion：＆A D．Keller，M．E．De Bakey，J．R．Pappenheimer，and F．D．Moore 173
The Effect of Hypothermia on the Peripheral Serum Levels of Free 17-Hydroxycorticoids in the Dog，and in Man＆W．F．Bernhard 175
Discussion：＆J．Cahn and H．Swan 178
Some Problems of Hematology in Hypothermia：An Introduction＆William H．Crosby，Jr 183
The Effect of Hypothermia on Platelets and White Cells in Dogs＆T．J．Villalobos，E．Adelson，and P．A．Riley 186
Discussion：＆C．M．Couves，D．Warren，J．E．Rhoads，J．A．Helmsworth，and J．Adams-Ray 194
Renal Functional Response to Hypothermia and Ischemia in Man and Dog＆J．H．Moyer，G．C．Morris，and M．E．De Bakey 199
Effect of Hypothermia on the Kidney＆R．K．Andjus 214
Discussion：＆P．A．Riley 218
Hypothermia and Temporary Occlusion of the Hepatic Circulation＆N．E．Shumway and F．J．Lewis 221
Effect of Hypothermia on Metabolism and Drug Detoxification in the Isolated Perfused Rabbit Liver＆I．Gray，R．R．Rueckert，and R．R．Rink 226
The Effect of Hypothermia on the Isolated Perfused Rat Liver＆R．W．Brauer 235
Effects of Cold on the Nervous System＆I．D．McQueen 243
Effects of Changes in Arterial pCO2 on Cerebral Blood Flow and Metabolism during Hypothermia＆I．Kleinerman 251
Hypothermia and the Central Nervous System＆H．L．Rosomoff 253
Hypothermia and the Nervous System＆C．McC．Brooks 260
Experimental and Clinical Observations on the Use of Hypothermia to Prevent Ischemic Damage to the Central Nervous System＆R．G．Pontius and M．E．De Bakey 264
Discussion：＆W．H．Lougheed 270
Possibilities and Limitations of Differential Brain Cooling in Dogs＆J．M．Jensen，W．M．Parkins，and H．M．Vars 271
Discussion：＆W．M．Parkins，J．Cahn，and J．D．McMurrey 274
REVIEW AND APPRAISAL OF PARTS Ⅰ AND Ⅱ＆J．W．Severinghaus 279
REVIEW AND APPRAISAL OF PARTS Ⅰ AND Ⅱ＆S．M．Horvath 284
PART Ⅲ－MYOCARDIAL IRRITABILITY AND HYPOTHERMIA 287
Hypothermia and the Physiology of Cardiac Excitability＆C．McC．Brooks 287
Temperature Effects on Cardiac Transmembrane Potentials＆B．F．Hoflman 302
Discussion：＆G．E．Burch，J．W．Severinghaus．and D．Durrer 324
Myocardial Irritability in Experimental Immersion Hypothermia＆A．H．Hegnauer and B．G．Covino 327
Discussion：＆F．J．Lewis，B．F．Hoffman，F．Gollan，A．Riberi，and J．Cahn 340
REVIEW AND APPRAISAL OF PART Ⅲ－C．McC．Brooks and B．F．Hoffman 355
PART Ⅳ－CLINICAL APPLICATION OF INDUCED HYPOTHERMIA 363
Hypothermia in Neurosurgery＆E．H．Botterell and W．M．Lougheed 363
Discussion：＆G．H．Clowes，Jr．，W．M．Lougheed，and E．H．Botterell 368
Effect of Hypothermia on Tolerance to Hemorrhagic Shock＆E．W．Friedman，D．Davidoff，and Jacob Fine 369
Discussion：＆E．Frank 378
Experimental Observations on the Influence of Hypothermia and Autonomic Blocking Agents on Hemorrhagic Shock＆R．C．Overton and M．E．De Bakey 381
Hypothermia and Experimental Myocardial Infarction＆Charles Huggim 392
Treatment of the Seriously Ill，Febrile Patient with Surface Cooling＆F．J．Lewis，D．M．Ring，and J．F．Alden 394
Discussion：＆W．J．Kolff，E．Calkins，H．Swan，F．J．Lewis，J．Henley，and C．W．Hughes 399
The Use of Hypothermia in Cardiac Surgery＆Henry Swan 402
Discussion：＆F．J．Lewis，J．H．Kay，I．K．R．McMillan，W．P．Longmire，Jr．，J．Cahn，C．W．Hughes，and H．Swan 409
REVIEW AND APPRAISAL OF PART Ⅳ＆R．D．Dripps 413
PART Ⅴ－TECHNIQUES OF INDUCING HYPOTHERMIA 415
Problems in Methods of Inducing Hypothermia by Use of External Cooling＆W．H．Muller，Jr．and J．F．Dammann 415
Problems in Methods of Inducing Hypothermia by Use of Drugs and Internal Cooling＆J．F．Dammann and W．H．Muller，Jr 422
Discussion：＆J．Adams-Ray，A．Riberi，R．O．Heimbecker，F．Gollan，R．W．Brauer，and L．I．Goldberg 430
REVIEW AND APPRAISAL OF PART Ⅴ＆R．D．Dripps 439
Attendance 441
Index of Authors and Discussants 447