1 Origins and Principles of Translational Control M．B．Mathews．N．Sonenberg,and J．W．B．Hershey 1
Contents 9
Preface 9
2 Pathway and Mechanism of Initiation of Protein Synthesis J．W．B．Hershey and W．C．Merrick 33
3 The Protein Biosynthesis Elongation Cycle W．C．Merrick and J．Nyborg 89
4 Comparative View of Initiation Site Selection Mechanisms R．J．Jackson 127
5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes A．G．Hinnebusch 185
6 Regulation of Ribosomal Recruitment in Eukaryotes B．Raught,A．-C．Gingras,and N．Sonenberg 245
7 Translational Control of Developmental Decisions M．Wickens,E．B．Goodwin,J．Kimble,S．Strickland,and M．Hentze 295
8 ViraI Translational Strategies and Host Defense Mechanisms T．Pe'ery and M．B．Mathews 371
9 Ribosomal Subunit Joining T．V．Pestova,T．E．Dever,and C．U．T．Hellen 425
10 Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A)Tail A．Sachs 447
11 Translation Termination：It's Not the End of the Story E．M．Welch,W Wang,and S．W．Peltz 467
12 Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae T．F．Donahue 487
13 Double-stranded RNA-activated Protein Kinase PKR R．J．Kaufman 503
14 Heme-regulated eIF2α Kinase J．-J．Chen 529
15 PERK and Translational Control by Stress in the Endoplasmic Reticulum D．Ron and H．P．Harding 547
16 Regulation of Translation Initiation in Mammalian Cells by Amino Acids S．R．Kimball and L．S．Jefferson 561
17 Translational Control during Heat Shock R．J．Schneider 581
18 Translational Control by Upstream Open Reading Frames A．P．Geballe and M．S．Sachs 595
19 Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation M．S．Carter,K．M．Kuhn．and．P．Sarnow 615
20 Iranslational Control and Cancer J．W．B．Hershey and S．Miyamoto 637
21 Translational Control of Ferritin Synthesis T．A．Rouault and J．B．Harford 655
22 Translational Control of TOP mRNAs O．Meyuhas and E．Hornstein 671
23 S6 Phosphorylation and Signal Transduction S．Fumagalli and G．Thomas 695
24 Control of the Elongation Phase of Protein Synthesis C．Proud 719
25 Programmed Translational Frameshifting,Hopping,and Readthrough of Termination Codons P．J Farabaugh,Q．Qian,and G．Stahl 741
26 Recoding UGA as Selenocysteine M．J．Berry 763
27 Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function J．D．Richter 785
28 Interaction of mRNA Translation and mRNA Degradation in Saccharomyces cerevisiae D．C．Schwartz and R．Parke r 807
29 Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae A．Jacobson and S．W．Peltz 827
30 Nonsense-mediated RNA Decay in Mammalian Cells：A Splicing-dependent Means to Down-regulate the Levels of mRNAs That Prematurely Terminate Translation L．E．Maquat 849
31 Translation Initiation on Picornavirus RNA G．J Relsham and R．J．Jackson 869
32 Adenovirus Inhibition of Cellular Protein Synthesis and Preferential Translation of Viral mRNAs R．J．Schneider 901
33 Reovirus Translational Control A．J．Shatkin 915
34 Translational Reprogramming during Influenza Virus Infection S．-L．Tan,M．Gale,Jr．,and M．G．Katze 933
35 Translational Control in Poxvirus-infected Cells B．L．Jacobs 951
36 Nontranslational Functions of Components of the Translational Apparatus T．G． Kinzy and E．Goldman 973
Index 999