基因表达的翻译调控 英文版PDF电子书下载

1 Origins and Principles of Translational Control M．B．Mathews．N．Sonenberg,and J．W．B．Hershey 1

Contents 9

Preface 9

2 Pathway and Mechanism of Initiation of Protein Synthesis J．W．B．Hershey and W．C．Merrick 33

3 The Protein Biosynthesis Elongation Cycle　W．C．Merrick　and J．Nyborg　 89

4 Comparative View of Initiation Site Selection Mechanisms　R．J．Jackson　 127

5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes　A．G．Hinnebusch　 185

6 Regulation of Ribosomal Recruitment in Eukaryotes B．Raught,A．-C．Gingras,and N．Sonenberg　 245

7 Translational Control of Developmental Decisions M．Wickens,E．B．Goodwin,J．Kimble,S．Strickland,and M．Hentze 295

8 ViraI Translational Strategies and Host Defense Mechanisms T．Pe'ery and M．B．Mathews　 371

9 Ribosomal Subunit Joining T．V．Pestova,T．E．Dever,and C．U．T．Hellen 425

10 Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A)Tail A．Sachs 447

11 Translation Termination：It's Not the End of the Story E．M．Welch,W Wang,and S．W．Peltz 467

12 Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae T．F．Donahue 487

13 Double-stranded RNA-activated Protein Kinase PKR R．J．Kaufman 503

14　Heme-regulated eIF2α Kinase J．-J．Chen 529

15 PERK and Translational Control by Stress in the Endoplasmic Reticulum D．Ron and H．P．Harding　 547

16 Regulation of Translation Initiation in Mammalian Cells by Amino Acids S．R．Kimball and L．S．Jefferson 561

17 Translational Control during Heat Shock R．J．Schneider 581

18 Translational Control by Upstream Open Reading Frames A．P．Geballe and M．S．Sachs 595

19　 Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation　M．S．Carter,K．M．Kuhn．and．P．Sarnow　 615

20 Iranslational Control and Cancer J．W．B．Hershey and S．Miyamoto 637

21 Translational Control of Ferritin Synthesis T．A．Rouault and J．B．Harford 655

22 Translational Control of TOP mRNAs O．Meyuhas and E．Hornstein 671

23 S6 Phosphorylation and Signal Transduction S．Fumagalli and G．Thomas 695

24 Control of the Elongation Phase of Protein Synthesis C．Proud 719

25 Programmed Translational Frameshifting,Hopping,and Readthrough of Termination Codons P．J Farabaugh,Q．Qian,and G．Stahl 741

26 Recoding UGA as Selenocysteine M．J．Berry 763

27 Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function J．D．Richter 785

28 Interaction of mRNA Translation and mRNA Degradation in Saccharomyces cerevisiae D．C．Schwartz and R．Parke r 807

29 Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae A．Jacobson and S．W．Peltz　 827

30 Nonsense-mediated RNA Decay in Mammalian Cells：A Splicing-dependent Means to Down-regulate the Levels of mRNAs That Prematurely Terminate Translation L．E．Maquat 849

31 Translation Initiation on Picornavirus RNA G．J Relsham and R．J．Jackson 869

32 Adenovirus Inhibition of Cellular Protein Synthesis and Preferential Translation of Viral mRNAs R．J．Schneider 901

33 Reovirus Translational Control A．J．Shatkin 915

34 Translational Reprogramming during Influenza Virus Infection S．-L．Tan,M．Gale,Jr．,and M．G．Katze 933

35 Translational Control in Poxvirus-infected Cells B．L．Jacobs 951

36 Nontranslational Functions of Components of the Translational Apparatus　T．G． Kinzy and E．Goldman 973

Index 999