PART 1 1
Introduction 1
INTRODUCTION TO CLINICAL PHARMACOLOGY AND RATIONAL THERAPEUTICS David W.Nierenberg, Kenneth L.Melmon 3
PART 2 63
Drug Therapy of Common Diseases: Problem-Based Therapeutic Decisions 63
CHAPTER 1 65
CARDIOVASCULAR DISORDERS 65
Hypertension Brian B.Hoffman, S.George Carruthers 65
Hypotension David Robertson 95
Coronary Artery Disease Thomas Michel, Mark S.Weinfeld 114
Acute Myocardial Infarction Christopher P.Cannon, Peter H.Stone 131
Heart Failure J.Malcolm O.Arnold 157
Arrhythmias Dan M.Roden 183
Peripheral Arterial Occlusive Disease Thomas L.Whitsett 207
Venous Thromboembolic Disease Brian G.Birdwell, Thomas L.Whitsett 214
Adverse Effects of Cardiovascular Drugs on the Cardiovascular System Stanley Nattel 229
CHAPTER 2 235
Introduction and General Approach to Therapy John A.Abisheganaden, Homer A.Boushey 235
Obstructive Lung Diseases: Treatment John A.Abisheganaden, Homer A.Boushey, Stephen I.Rennard 238
Asthma John A.Abisheganaden, Homer A.Boushey 260
Chronic Obstructive Pulmonary Disease Stephen I.Rennard 265
Cystic Fibrosis Moira L.Aitken, Mark Tonelli 271
Pneumonia Michael S.Niederman 275
Pulmonary Vascular Disease Sean P.Gaine 289
Idiopathic Pulmonary Fibrosis Naseema B.Merchant, Paul W.Noble 293
Drug-Induced Lung Disease Naseema B.Merchant, Paul W.Noble 297
CHAPTER 3 303
GASTRO, NTESTINAL DISORDERS Gabriel Garcia 303
CHAPTER 4 319
HEPATR DISORDERS AND THE INFLUENCE OF LIVER FGNCIION ON DRUG DISPOSITION Gabriel Garcia 319
CHAPTER 5 341
? Elizabeth M.Ross, Irwin H.Rosenberg 341
CHAPTER 6 363
? D.Craig Brater 363
CHAPTER 7 401
? 401
Headache Thomas N.Ward 401
Seizures Richard S.McLachlan 411
Cerebrovascular Diseases Arturo Tamayo, Vladimir Hachinski 423
Parkinson s Disease David J.Coffey 437
Dementia Lawrence R.Jenkyn 445
Multiple Sclerosis: Current Treatment G.P.A.Rice,George C.Ebers 453
Myasthenia Gravis Michael W.Nicolle 460
Drug-Induced Neurologic Disorders B.M.Demaerschalk, P.E.Cooper 480
CHAPTER 8 489
PSYOHATRIC DISORDERS Leo E.Hollister 489
CHAPTER 9 529
ENDC CRINE AND MEFABOHC DISORDERS 529
Diabetes Mellitus Jeffrey W.Miller, Fredric B.Kraemer 529
Dyslipidemias Fredric B.Kraemer, Jeffery W.Miller 552
Adrenal Steroids Jeffrey W.Miller 581
Thyroid Disease Jeffrey W.Miller 594
Reproductive Steroids Jeffrey W.Miller 610
Hypothalamic Hormone Therapy Steven A.Lieberman, Andrew R.Hoffman 637
CHAPTER 10 645
CONNECTIVE TISSUE AND BONE DISORDERS 645
Rheumatic Disorders Richard Day, David Quinn, Kenneth Williams, Malcolm Handel, Peter Brooks 645
Osteoporosis Robert Marcus 703
CHAPTER 11 713
DERMATOLOGIC DISORDERS Christopher M.Barnard, Marc E.Coldyne 713
CHAPTER 12 737
HEM TOIOGIC DISORDERS Richard Lin, Zhuo-Wei Hu 737
ONCOLOGIC DISORDERS Joseph R.Bertino, Owen A.O Connor 799
CHAPTER 13 799
CHAPTER 14 873
INFECTIOUS DISORDERS Thomas J.Marrie,Claire Touchie,B.Lynn Johnston, Kevin R.Forward, Kathryn L.Slayter, Spencer Lee, Paul Hoffman 873
CHAPTER 15 1003
CONSCIOUS SEDATION AND PAN Mervyn Maze ,John C.Hunter, Raymond R.Gaeta 1003
CHAPTER 16 1029
TREATMENT IN THE INTENSIVE CARE UNIT David J.Liepert, Ronald G.Pearl 1029
CHAPTER 17 1053
SUBSTANCE ABUSE: DEPENDENCE AND TREATMENT Lori D.Karan, Neal L.Benowitz 1053
CHAPTER 18 1091
POISONING Lewis S.Nelson, Lewis R.Goldfrank 1091
PART 3 1115
Core Topics in Clinical Pharmacology 1115
DRUG THERAPY IN PREGNANT AND BREAST-FEEDING WOMEN Peter C.Rubin, Jane M.Rutherford 1117
CHAPTER 19 1117
CHAPTER 20 1143
DRUG THERAPY IN PEDIATRIC PATIENTS Ronen Loebstein, Sunita Vohra, Gideon Koren 1143
CHAPTER 21 1151
GERIATRIC PHARMACOLOGY Robert E.Vestal, Jerry H.Gurwitz 1151
CHAPTER 22 1179
PHARMACOGENETICS Urs A.Meyer 1179
CHAPTER 23 1207
CLINICAL PHARMACOKINETICS AND PHARMACODYNAMICS Daniel S.Sitar 1207
CHAPTER 24 1223
ADVERSE DRUG REACTIONS David W.Bates, Lucian Leape 1223
DRUG INTERACTIONS James M.Wright 1257
CHAPTER 25 1257
CHAPTER 26 1267
WRITING PRESCRIPTIONS Terrence F.Blaschke 1267
CHAPTER 27 1289
DRUG DISCOVERY AND DEVELOPMENT Richard D.Mamelok 1289
CHAPTER 28 1307
RISK ANALYSIS APPLIED TO PRESCRIPTION DRUGS John Urquhart 1307
CHAPTER 29 1319
THE CLINICIAN S ACTIONS WHEN N=1 Gordon Guyatt, David L.Sackett 1319
CHAPTER 30 1329
INFORMATION ABOUT DRUGS: A CLINICAL EPIDEMIOLOGIC APPROACH TO THERAPEUTICS Brian L.Strom 1329
Appendix 1341
Index 1347