Ⅰ.BASIC PRINCIPLES 1
1.Introduction&Bertram G.Katzung, MD, PhD 1
2.Drug Receptors ＆ Pharmacodynamics&Henry R.Bourne, MD, ＆ Mark von Zastrow, MD, PhD 9
3.Pharmacokinetics ＆ Pharmacodynamics: Rational Dosing ＆ the Time Course of Drug Action&Nicholas H.G.Holford, MB, ChB, FRACP 35
4.Drug Biotransformation&Maria Almira Correia, PhD 51
5.Basic ＆ Clinical Evaluation of New Drugs&Barry A.Berkowitz, PhD, ＆ Bertram G.Katzung, MD, PhD 64
Ⅱ.AUTONOMIC DRUGS 75
6.Introduction to Autonomic Pharmacology&Bertram G.Katzung, MD, PhD 75
7.Cholinoceptor-Activating ＆ Cholinesterase-Inhibiting Drugs&Achilles J.Pappano, PhD 92
8.Cholinoceptor-Blocking Drugs&Achilles J.Pappano, PhD, ＆ Bertram G.Katzung, MD, PhD 107
9.Adrenoceptor-Activating ＆ Other Sympathomimetic Drugs&Brian B.Hoffman, MD 120
10.Adrenoceptor Antagonist Drugs&Brian B.Hoffman, MD 138
Ⅲ.CARDIOVASCULAR-RENAL DRUGS 155
11.Antihypertensive Agents&Neal L.Benowitz，MD 155
12.Vasodilators ＆ the Treatment of Angina Pectoris&Bertram G.Katzung, MD, PhD, ＆ Kanu Chatterjee, MB, FRCP 181
13.Cardiac Glycosides ＆ Other Drugs Used in Congestive Heart Failure&Bertram G.Katzung, MD, PhD, ＆ William W.Parmley, MD 200
14.Agents Used in Cardiac Arrhythmias&Luc M.Hondeghem, MD, PhD, ＆ Dan M.Roden, MD 219
15.Diuretic Agents&Harlan E.lves,MD,PhD 245
Ⅳ.DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE 265
16.Histamine, Serotonin, ＆ the Ergot Alkaloids&Bertram G.Katzung, MD, PhD, ＆ David J.Julius, PhD 265
17.Vasoactive Peptides&lan A.Reid, PhD 292
18.The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes,＆ Related Compounds&Marie L.Foegh, MD, DSc, ＆ Peter W.Ramwell, PhD 311
19.Nitric Oxide, Donors, ＆ Inhibitors&George Thomas, PhD, ＆ Peter W.Ramwell, PhD 326
20.Drugs Used in Asthma&Homer A.Boushey, MD 333
Ⅴ.DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM 351
21.Introduction to the Pharmacology of CNS Drugs&Roger A.Nicoll, MD 351
22.Sedative-Hypnotic Drugs&Anthony J.Trevor, PhD, ＆ Walter L.Way, MD 364
23.The Alcohols&Susan B.Masters,PhD 382
24.Antiseizure Drugs&Roger J.Porter, MD,＆ Brian S.Meldrum, MB, PhD 395
25.General Anesthetics&Anthony J.Trevor, PhD,＆Ronald D.Miller, MD 419
26.Local Anesthetics&Ronald D.Miller, MD, ＆ Bertram G.Katzung,MD,PhD 436
27.Skeletal Muscle Relaxants&Ronald D.Miller, MD, ＆ Bertram G.Katzung, MD, PhD 446
28.Pharmacologic Management of Parkinsonism ＆ Other Movement Disorders&Michael J.Aminoff, MD, FRCP 463
29.Antipsychotic Agents ＆ Lithium&William Z.Potter, MD, PhD, ＆ Leo E.Hollister, MD 478
30.Antidepressant Agents&William Z.Potter, MD, PhD, ＆ Leo E.Hollister, MD 498
31.Opioid Analgesics ＆ Antagonists&Walter L.Way,MD,Howard L.Fields,MD,PhD,＆ Mark A.Schumacher, PhD, MD 512
32.Drugs of Abuse&Thomas R.Kosten, MD, and Leo E.Hollister, MD 532
Ⅵ.DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, ＆ GOUT 549
33.Agents Used in Anemias; Hematopoietic Growth Factors&Daniel V.Santi, MD,PhD, ＆ Susan B.Masters, PhD 549
34.Drugs Used in Disorders of Coagulation&Julie Hambleton, MD, ＆ Robert A.O'Reilly, MD 564
35.Agents Used in Hyperlipidemia&Mary J.Malloy, MD, ＆ John P.Kane, MD, PhD 581
36.Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, ＆ Drugs Used in Gout&Daniel E Furst, MD, ＆ Tino Munster, MD 596
Ⅶ.ENDOCRINE DRUGS 625
37.Hypothalamic ＆ Pituitary Hormones&Paul A.Fitzgerald, MD 625
38.Thyroid ＆ Antithyroid Drugs&Francis S.Greenspan, MD, ＆ Betty J.Dong, PharmD 644
39.Adrenocorticosteroids ＆ Adrenocortical Antagonists&George P.Chrousos, MD, ＆ Andrew N.Margions, MD 660
40.The Gonadal Hormones ＆ Inhibitors&George P.Chrousos, MD, Emmanouil N.Zoumakis,PhD, ＆ Achille Gravanis, PhD 679
41.Pancreatic Hormones ＆ Antidiabetic Drugs&Martha S.Nolte, MD, ＆ John H.Karam, MD 711
42.Agents That Affect Bone Mineral Homeostasis&Daniel D.Bikle, MD, PhD 735
Ⅷ.CHEMOTHERAPEUTIC DRUGS 754
43.Beta-Lactam Antibiotics ＆ Other Inhibitors of Cell Wall Synthesis&Henry F.Chambers,MD 754
44.Chloramphenicol, Tetracyclines, Macrolides, Clindamycin, ＆ Streptogramins&Henry F.Chambers, MD 774
45.Aminoglycosides ＆ Spectinomycin&Henry F.Chambers, MD 784
46.Sulfonamides, Trimethoprim, ＆ Quinolones&Henry F.Chambers, MD 793
47.AntimycobacterialDrugs&Henry F.Chambers,MD 803
48.AntifungalAgents&Don Sheppard, MD,＆ Harrry W.Lampiris, MD 814
49.AntiviralAgents&Sharon Safrin, MD 823
50.Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, ＆ Sterilants&Henry F.Chambers, MD 845
51.Clinical Use of Antimicrobial Agents&Harry W.Lampiris, MD, ＆ Daniel S.Maddix, PharmD 854
52.Basic Principles of Antiparasitic Chemotherapy&Ching Chung Wang, PhD 869
53.AntiprotozoalDrugs&Philip J.Rosenthal, MD, ＆ Robert S.Goldsmith, MD, DTM＆H 882
54.Clinical Pharmacology of the Anthelmintic Drugs&Robert S.Goldsmith, MD, DTM＆H 903
55.Cancer Chemotherapy&Sydney E.Salmon, MD, ＆ Alan C.Sartorelli, PhD 923
56.Immunopharmacology&Douglas F.Lake, PhD, Emmanuel T.Akporiaye, PhD, ＆ Evan M.Hersh, MD 959
Ⅸ.TOXICOLOGY 987
57.Introduction to Toxicology: Occupational ＆ Environmental&Gabriel L.Plaa, PhD 987
58.Heavy Metal Intoxication ＆ Chelators&Michael J.Kosnett, MD, MPH 999
59.Management of the Poisoned Patient&Kent R.Olson, MD 1011
Ⅹ.SPECIAL TOPICS 1025
60.Special Aspects of Perinatal ＆ Pediatric Pharmacology&Gideon Koren, MD 1025
61.Special Aspects of Geriatric Pharmacology&Bertram G.Katzung, MD, PhD 1036
62.Dermatologic Pharmacology&Dirk B.Robertson, MD, ＆ Howard I.Maibach, MD 1045
63.Drugs Used in Gastrointestinal Diseases&David F.Altman, MD 1064
64.Therapeutic ＆ Toxic Potential of Over-the-Counter Agents&Robin L.Corelli, PharmD, ＆ Mary Anne Koda-Kimble, PharmD 1077
65.Botanicals （“Herbal Medications”） ＆ Nutritional Supplements&Cathi E.Dennehy, PharmD, ＆ Candy Tsourounis, PharmD 1088
66.Rational Prescribing ＆ Prescription Writing&Paul W.Lofholm, PharmD, ＆ Bertram G.Katzung, MD, PhD 1104
Appendix Ⅰ.Vaccines, Immune Globulins, ＆ Other Complex Biologic Products&Harry W.Lampiris, MD, ＆ Daniel S.Maddix, PharmD 1113
Appendix Ⅱ.Important Drug Interactions ＆ Their Mechanisms&Philip D.Hansten, PharmD 1122
Index 1135