第一章 导论 1
第一节 中医科学的新基础 The brand-new fundation ofTraditional Chinese Medicine(TCM) 2
第二节 整体观念与基因组学 TCM Integrity principal and the genomics 4
第三节 辨证论治与临床遗传原理 TCM Differentiation principles and clinical genetics 5
第四节 深层次运用分子生物学技术 Further approaches upon Edge-Cutting molecular biolgical techiques 7
第二章 阴阳学说与分子生物学 11
第一节 宏观人天阴阳律 Macroscopic Yin-Yang Theory of human being and their environments 12
第二节 微观分子阴阳律 Microscopic Yin-Yang Theory of Dynamics in Organic molecular 14
第三节 基因属性阴阳析 Property analysis of genes with Yin-Yang Theory 16
第四节 分子遗传阴阳析 Molecular genetics approaches through Yin-Yang Theory 19
第五节 等位基因阴阳析 Alleles assessment by Yin-Yang Theory 21
第六节 复制翻译阴阳析 Transcription and translation outlined by Yin-Yang Theory 23
第七节 分子运动阴阳析 Molecular dynamics in view of Yin-Yang Theory 25
第八节 基因合化阴阳析 Gene dynamics analogy with Yin-Yang Theory 28
第九节 分子状态阴阳析 Yin-Yang Implies of molecular status 31
第三章 藏象学说与分子生物学 35
第一节 藏象分子研究的界定 A molecular definition of viscera-status theory 36
第二节 肝胆与基因 Reciprocal reaction of Liver-Gall system and relevant genes 37
第三节 心小肠与基因 Reciprocal reaction ofHeart-Small intestine system and relevant genes 39
第四节 脾胃与基因 Reciprocal reaction of Spleen-Stomach system and relevant genes 41
第五节 肺大肠与基因 Reciprocal reaction of Lung-Large intestine system and relevant genes 45
第六节 肾膀胱与基因 Reciprocal reaction of Kidney-Urinary bladder system and relevant genes 47
第四章 气血学说与分子生物学 53
第一节 气的泛义及界定困难 The general definition ofQi and problems within 54
第二节 气乃功能基因组的表现 Qi might be the demonstration of function genomics 55
第三节 基因的功能与气的作用 Principal effects of Qi and function of relevant genes 57
第四节 血与基因 Blood and relevant genes 60
第五章 运气环境与HLA 64
第一节 运气与寒暑相关基因 Yun-Qi,season change and the genes relate to cold or hot 65
第二节 运气环境与易感基因应答 Yun-Qi,climatic factors and the adaptive response of sensible genes 67
第三节 HLA的藏象功能分类 HLA system and functional classifications of the viscera-status theory 69
第四节 运气六淫与HLA易感性 Yun-Qi,six extreme weather conditions and the sensibility of HLA genes 71
第五节 HLA转基因与体质辨证 Transgene upon HLA and the differentiation in somatic construction 74
第六章 七情心理与基因 79
第一节 七情研究层次的深入 Upgraded studies on Seven Emotions 80
第二节 “恐伤肾”的应激模型 The stress mice model of“Fear impairs Kidney” 81
第三节 “恐伤肾”的即早基因表达 The early expressed genes of stress model“Fear impairs Kidney” 83
第四节 “恐伤肾”的差异基因表达 The differential expressed genes of stress model“Fear impairs Kidney”and 84
第五节 “恐伤”心理的基因定势表达 Gene expressive norm under emotion panic 88
第六节 “五劳”行为的基因定势表达 Behavioral gene expressive norm upon conditions of Five-Fatigue 91
第七章 四诊证治与遗传基因 95
第一节 证有分子生物学基础的假说 A hypothesis of TCM Symptoms include molecular basics 96
第二节 辨证的遗传学基础及方法 Differentiation methods and the aekownledge of genetics 98
第三节 相诊的遗传背景与中西医异同 The genetic background of Inspection,Physiognomy,and Comparation between western medicine and TCM 100
第四节 舌诊的基因与遗传 Inspection upon the tongue and genetics 102
第五节 脉诊的基因与遗传 Inspection upon the Pulse condition and genetics 106
第六节 遗传差异与辨证分型 Individual genetic difference and the Symptom differentiation 109
第八章 八纲辨证与基因 114
第一节 概论 Introduction 115
第二节 阴阳辨证与基因 Differentiation of Yin-Yang Symptoms and genes 117
第三节 寒热辨证与基因 Differentiation of Cold-Hot Symptoms and genes 119
第四节 虚实辨证与 HLA Differentiation of Deficiency-Excess Symptoms and HLA 121
第五节 虚实辨证与分子机制 Differentiation of Deficiency-Excess and its molecular mechanism 123
第六节 虚实辨证与基因诊断 Differentiation of Deficiency-Excess Symptoms and gene diagnosis 126
第九章 中医遗传学理论 134
第一节 中医遗传学的形成与发展 The establishment and development of TCM Genetics 135
第二节 中医遗传学是新学科的升华 The rise of TCM Genetics as a brand-new discipline 136
第三节 中医遗传学是中基的突破 TCM Genetics emblems a breakthrough of TCM 139
第四节 中医遗传学具有战略意义 The strategic significance of TCM genetics 141
第五节 中医遗传学的分科切入 Development of the major disciplines of TCM genetics 142
第六节 易理遗传及因素分析 Factor analysis of the genetic principle upon the theory YI 145
第十章 中医遗传学临床 148
第一节 概说 Introduction 149
第二节 中医防治遗传病 Prevention and therapy of genetic diseases by TCM 151
第三节 《内经》遗传病提要 Outline of the genetic diseases in NEI JING 153
第四节 两个家族的抗痘麻力及寿限比较 Comparative genetic studies two family trees with their anti-smallbox and anti-measles character against those of life spans 156
第五节 家族性头痛及古代医案的基因分析 Gene analysis focusing on the family headache taken from the famous collects of ancient Chinese medical cases 159
第十一章 中医遗传学的实验 166
第一节 子代肾虚鼠的生理研究 Physiological study on the Offspring of Kidney Deficiency Mice(OKDM) 167
第二节 子代肾虚鼠的病理研究 Pathological study on OKDM 169
第三节 子代肾虚鼠脏器的红外研究 Infrared-ray spectrum study on the OKDM 172
第四节 子代肾虚鼠的行为遗传研究 Behavioral genetic investigation of the OKDM 174
第五节 子代肾虚鼠的免疫生化研究 Immunology and biochemistry approach on the OKDM 176
第六节 子代肾虚鼠的先天补肾研究 Therapy assess of congenial Kidney tonic on the OKDM 178
第十二章 建立中药分子药性学 183
第一节 中药分子药性学引导 Introduction of molecular pharmacology of TCM 184
第二节 分子生药学的研究进展 Review on the molecular pharmacology of TCM 186
第三节 人参的分子药性学研究 Study on the molecular pharmacology of Ginseng 189
第四节 黄芪的分子药性学研究 Study on the molecular pharmacology of Astragus M. 190
第五节 丹参的分子药性学研究 Study on the molecular pharmacology of Salvia M. 192
第六节 灵芝的分子药性学研究 Study on the molecular pharmacology of Magic fungus 194
第七节 水蛭等分子药性学研究 Study on the molecular pharmacology of Leech,etc 195
第十三章 复方的分子机制 200
第一节 概说 Introduction 201
第二节 补益剂的分子机制 Molecular mechanism oftonic prescription 203
第三节 活血剂的分子机制 Molecular mechanism of circulation-promoting prescription 206
第四节 清热剂的分子机制 Molecular mechanism of Heat-clear prescription 208
第五节 和解剂等分子机制 Molecular mechanism of Reconcile prescriotion,etc 210
第十四章 补肾方的分子机制 214
第一节 概说 Introduction 215
第二节 滋补肾阴方的分子机制 Molecular mechanism of Kidney Yin-tonic prescription 217
第三节 温肾补阳方的分子机制 Molecular mechanism of Kidney Yang-tonic prescription 220
第四节 益肾兼泻方的分子机制 Molecular mechanism of tonic-plus-dispelling prescription 224
第十五章 肿瘤的中医分子生物学研究 230
第一节 概说 Introduction 231
第二节 胃癌的中医分子机制研究 Molecular mechanism of TCM study on stomach cancer 232
第三节 肝癌的中医分子机制研究 Molecular mechanism of TCM study on liver cancer 235
第四节 白血病的中医分子机制研究 Molecular mechanism of TCM study on leukemia 237
第五节 鼻咽癌等中医分子机制研究 Molecular mechanism of TCM study on nasopharyngeal,carcinoma,etc 239
第十六章 红斑狼疮遗传背景及中医研究前瞻 245
第一节 概说 Introduction 246
第二节 狼疮遗传素质与先天肾本 Genetics backgrounds of SLE patients and their relationships with those of the congenital Kidney 248
第三节 红斑狼疮的病机及分子机制 Pathogenesis of SLE and its molecular mechanism of SLE 250
第四节 狼疮的HLA及转基因研究前瞻 The HLA pattern of SLE and transgene therapy 252
第五节 狼疮的亲子用药及中西医互补 Therapy on both parents and children by coordinated activities of TCM and western medicine on treatment of SLE 254
第十七章 老年痴呆的中医分子生物学研究前瞻 259
第一节 概说 Introduction 260
第二节 肾本-基因论老年痴呆的分子机制 Molecular mechanism of kidney-gene hypothesis upon the aged dementia 262
第三节 邪正观析老年痴呆成对指标 Evil-Right paired index analysis on the aged dementia 265
第四节 中医对痴呆的行为细胞及基因研究 Behavioral,cellular and genetic researches on aged dementia by meaning of TCM 267
第五节 肾本-基因论前瞻老年痴呆的研究 Prospect on the TCM molecular pharmacology study on the senior and aged dementia 270
第六节 基因芯片展示衰老鼠的基因表达谱 Microarray demonstration of the differential expressed gene profiles on the animals model of aged 271
第十八章 针灸的分子生物学研究及前瞻 279
第一节 概说 Introduction 280
第二节 针刺镇痛的分子机制研究 Molecular mechanism study on the acupuncture analgesia 281
第三节 针灸调节 神经免疫的分子机制 Molecular modulatory mechanism of the acupuncture effect on the neuro-immunology axle 284
第四节 针灸分子生物学研究的前瞻 Prospect of the molecular studies on the special therapy acupuncture 286
第五节 针刺衰老鼠涌泉穴的p53基因表达 The expression of p53 induced by acupuncture on the Yong-Quan point of aged model of mice 288
第十九章 “肾本遗传”研究(国家自然科学基金资助项目) 293
第一节 “肾为先天之本”实验的提案 Propose of the experiment study on the TCM principal that Kidney is the congenital fundamental of human being 294
第二节 肾本遗传的创新四论 The four novel theories of congenital fundamental of Kidney 297
第三节 先天行为与免疫学研究 Study on congenital behavior and immunology 298
第四节 肾本遗传的实验初阶 Primary studies on Kidney congenital genetics 300
第五节 肾本行为遗传的研究鉴定 Appraisal of the behavoiral genetic studies of congenital Kidney 301
第六节 肾本行为遗传的基因表达研究 Behavoiral gene expression pattern on congenital Kidney 304
第七节 肾阳虚证的基因芯片研究立论 Construct microarray approach on the differential expressed gene profiles of the Kidney Yang-deficiency 307
第二十章 中医分子流行病学发展前瞻 312
第一节 分子与人类基因组流行病学 Molecular and human genomic researches with epidemics 313
第二节 中医科学应切入分子流行病学 Requiring of TCM stepping into the molecular epidemics 315
第三节 中医流行病学现状横览 Updated conditions about the epidemics studies of TCM 317
第四节 分子流行病学调研示例 Investigation samples to show the methods of TCM epidemics 320
第五节 中医分子流行病学前瞻纵论 Prospect on the molecular approaching to TCM epidemics 322
第二十一章 天年长寿与基因 327
第一节 天年寿限与长寿基因 The life-span,longevity and longevity genes 328
第二节 长寿阴阳的时空有序展开 Deployment according to the special period and space programme of Yin-Yang theory with longevity 330
第三节 寿命环境与遗传基因 Coordinated of environmental factors and genes on longevity 332
第四节 远古至唐百岁老人的遗传与环境分析 Genetics and envirorment study on the cases from ancient to Tang dynasty 336
第五节 五代至清百岁老人的遗传与环境的分析 Genetics and envirorment study on the cases from Five dynasty to Qing dynasty 343
第六节 陈氏颖川支系智能遗传分析 Genetic analysis of family intelligent on Yingchuan division of Chen 348
第二十二章 养生延年与基因 354
第一节 易理寿限及遗传病 Longevity of the Theory YI and genetic diseases 355
第二节 中医抗衰老论及基因 TCM theory of the anti-aged and relevant genes 362
第三节 抗衰老方药及分子机制 Study on anti-aged Chinese medicine and molecular mechanism 365
第四节 太极气功养生及遗传禀赋 TCM regimen,Taiji and Qigong,and relationship with congenital character 367
第五节 三国皇族寿命及疾病的研究 Longevity patterns and disease research on the emperial families of the Three-kingdom Dynasty 370
第六节 宋帝贵族寿命及疾病的研究 Longevity pattern and disease research on the imperial and noble families of Song dynasty 375
第二十三章 中医分子生物学科研计划前瞻 383
第一节 脾肾藏象的分子生物学研究切入 The edge-cutting TCM projects about the Spleen and Kidney system in views of molecular biology 384
第二节 肾虚证候与基因谱的贯通研究 Series and breakthrough studies on the relationships between Kidney deficiency Syndrome and expressed gene profiles 386
第三节 针药补肾分子机制的同一性研究 Identification on the Molecular machanism of acupuncture compared with Chinese medicine 387
第四节 应激恐伤肾的母子基因谱比较Comparative studies on the expression gene profiles between the parents and offspring upon the panic stress mice model 389
第五节 先天补肾的分子遗传学研究 Pharmacological studies on the molecular mechanism of the therapy of Congenital Kidney supplement 391
第六节 抑制消减杂交筛选证-药的相关基因谱 Screening the Symdrome-drug relevant Gene Screeh by employing method of Suppress Subtractive Hybridization(SSH) 392
第七节 基因芯片研究肾虚证主效基因的战略 Microarray strategies on the screen of the major genes responed to Kidney deficiency 394
第二十四章 古代的基因猜想与前沿的实证研究 401
第一节 古代图谱远距离地猜测基因 Primordial hypothesis about gene derived from the remote figure 402
第二节 易理四象大跨度地推衍基因 Gene conjecture logically from the Theory YI and four-dimensional theory 406
第三节 经典理论高容量地涵盖基因 Classical theories included the idea of gene highly 414
第四节 c-fos基因表达研究应激肾虚 Research of the c-fos expression on the Kidney deficiency model mice which were induced by panic stress 422
第五节 抑制消减杂交初选肾阳虚的相关基因 Screen the Kidney Yang deficiency by utilizing method of Suppressed Subtractive Hybridization(SSH) 425
第六节 基因芯片探索针刺衰老鼠的循证研究 Evidence-dependent investigation on the microarray gene profile of the aged mice model treated by acupuncture 428