中医分子生物学 分子中医学PDF电子书下载

第一章 导论 1

第一节 中医科学的新基础 The brand-new fundation ofTraditional Chinese Medicine(TCM) 2

第二节 整体观念与基因组学 TCM Integrity principal and the genomics 4

第三节 辨证论治与临床遗传原理 TCM Differentiation principles and clinical genetics 5

第四节 深层次运用分子生物学技术 Further approaches upon Edge-Cutting molecular biolgical techiques 7

第二章 阴阳学说与分子生物学 11

第一节 宏观人天阴阳律 Macroscopic Yin-Yang Theory of human being and their environments 12

第二节 微观分子阴阳律 Microscopic Yin-Yang Theory of Dynamics in Organic molecular 14

第三节 基因属性阴阳析 Property analysis of genes with Yin-Yang Theory 16

第四节 分子遗传阴阳析 Molecular genetics approaches through Yin-Yang Theory 19

第五节 等位基因阴阳析 Alleles assessment by Yin-Yang Theory 21

第六节 复制翻译阴阳析 Transcription and translation outlined by Yin-Yang Theory 23

第七节 分子运动阴阳析 Molecular dynamics in view of Yin-Yang Theory 25

第八节 基因合化阴阳析 Gene dynamics analogy with Yin-Yang Theory 28

第九节 分子状态阴阳析 Yin-Yang Implies of molecular status 31

第三章 藏象学说与分子生物学 35

第一节 藏象分子研究的界定 A molecular definition of viscera-status theory 36

第二节 肝胆与基因 Reciprocal reaction of Liver-Gall system and relevant genes 37

第三节 心小肠与基因 Reciprocal reaction ofHeart-Small intestine system and relevant genes 39

第四节 脾胃与基因 Reciprocal reaction of Spleen-Stomach system and relevant genes 41

第五节 肺大肠与基因 Reciprocal reaction of Lung-Large intestine system and relevant genes 45

第六节 肾膀胱与基因 Reciprocal reaction of Kidney-Urinary bladder system and relevant genes 47

第四章 气血学说与分子生物学 53

第一节 气的泛义及界定困难 The general definition ofQi and problems within 54

第二节 气乃功能基因组的表现 Qi might be the demonstration of function genomics 55

第三节 基因的功能与气的作用 Principal effects of Qi and function of relevant genes 57

第四节 血与基因 Blood and relevant genes 60

第五章 运气环境与HLA 64

第一节 运气与寒暑相关基因 Yun-Qi,season change and the genes relate to cold or hot 65

第二节 运气环境与易感基因应答 Yun-Qi,climatic factors and the adaptive response of sensible genes 67

第三节 HLA的藏象功能分类 HLA system and functional classifications of the viscera-status theory 69

第四节 运气六淫与HLA易感性 Yun-Qi,six extreme weather conditions and the sensibility of HLA genes 71

第五节 HLA转基因与体质辨证 Transgene upon HLA and the differentiation in somatic construction 74

第六章 七情心理与基因 79

第一节 七情研究层次的深入 Upgraded studies on Seven Emotions 80

第二节 “恐伤肾”的应激模型 The stress mice model of“Fear impairs Kidney” 81

第三节 “恐伤肾”的即早基因表达 The early expressed genes of stress model“Fear impairs Kidney” 83

第四节 “恐伤肾”的差异基因表达 The differential expressed genes of stress model“Fear impairs Kidney”and 84

第五节 “恐伤”心理的基因定势表达 Gene expressive norm under emotion panic 88

第六节 “五劳”行为的基因定势表达 Behavioral gene expressive norm upon conditions of Five-Fatigue 91

第七章 四诊证治与遗传基因 95

第一节 证有分子生物学基础的假说 A hypothesis of TCM Symptoms include molecular basics 96

第二节 辨证的遗传学基础及方法 Differentiation methods and the aekownledge of genetics 98

第三节 相诊的遗传背景与中西医异同 The genetic background of Inspection,Physiognomy,and Comparation between western medicine and TCM 100

第四节 舌诊的基因与遗传 Inspection upon the tongue and genetics 102

第五节 脉诊的基因与遗传 Inspection upon the Pulse condition and genetics 106

第六节 遗传差异与辨证分型 Individual genetic difference and the Symptom differentiation 109

第八章 八纲辨证与基因 114

第一节 概论 Introduction 115

第二节 阴阳辨证与基因 Differentiation of Yin-Yang Symptoms and genes 117

第三节 寒热辨证与基因 Differentiation of Cold-Hot Symptoms and genes 119

第四节 虚实辨证与 HLA Differentiation of Deficiency-Excess Symptoms and HLA 121

第五节 虚实辨证与分子机制 Differentiation of Deficiency-Excess and its molecular mechanism 123

第六节 虚实辨证与基因诊断 Differentiation of Deficiency-Excess Symptoms and gene diagnosis 126

第九章 中医遗传学理论 134

第一节 中医遗传学的形成与发展 The establishment and development of TCM Genetics 135

第二节 中医遗传学是新学科的升华 The rise of TCM Genetics as a brand-new discipline 136

第三节 中医遗传学是中基的突破 TCM Genetics emblems a breakthrough of TCM 139

第四节 中医遗传学具有战略意义 The strategic significance of TCM genetics 141

第五节 中医遗传学的分科切入 Development of the major disciplines of TCM genetics 142

第六节 易理遗传及因素分析 Factor analysis of the genetic principle upon the theory YI 145

第十章 中医遗传学临床 148

第一节 概说 Introduction 149

第二节 中医防治遗传病 Prevention and therapy of genetic diseases by TCM 151

第三节 《内经》遗传病提要 Outline of the genetic diseases in NEI JING 153

第四节 两个家族的抗痘麻力及寿限比较 Comparative genetic studies two family trees with their anti-smallbox and anti-measles character against those of life spans 156

第五节 家族性头痛及古代医案的基因分析 Gene analysis focusing on the family headache taken from the famous collects of ancient Chinese medical cases 159

第十一章 中医遗传学的实验 166

第一节 子代肾虚鼠的生理研究 Physiological study on the Offspring of Kidney Deficiency Mice(OKDM) 167

第二节 子代肾虚鼠的病理研究 Pathological study on OKDM 169

第三节 子代肾虚鼠脏器的红外研究 Infrared-ray spectrum study on the OKDM 172

第四节 子代肾虚鼠的行为遗传研究 Behavioral genetic investigation of the OKDM 174

第五节 子代肾虚鼠的免疫生化研究 Immunology and biochemistry approach on the OKDM 176

第六节 子代肾虚鼠的先天补肾研究 Therapy assess of congenial Kidney tonic on the OKDM 178

第十二章 建立中药分子药性学 183

第一节 中药分子药性学引导 Introduction of molecular pharmacology of TCM 184

第二节 分子生药学的研究进展 Review on the molecular pharmacology of TCM 186

第三节 人参的分子药性学研究 Study on the molecular pharmacology of Ginseng 189

第四节 黄芪的分子药性学研究 Study on the molecular pharmacology of Astragus M. 190

第五节 丹参的分子药性学研究 Study on the molecular pharmacology of Salvia M. 192

第六节 灵芝的分子药性学研究 Study on the molecular pharmacology of Magic fungus 194

第七节 水蛭等分子药性学研究 Study on the molecular pharmacology of Leech,etc 195

第十三章 复方的分子机制 200

第一节 概说 Introduction 201

第二节 补益剂的分子机制 Molecular mechanism oftonic prescription 203

第三节 活血剂的分子机制 Molecular mechanism of circulation-promoting prescription 206

第四节 清热剂的分子机制 Molecular mechanism of Heat-clear prescription 208

第五节 和解剂等分子机制 Molecular mechanism of Reconcile prescriotion,etc 210

第十四章 补肾方的分子机制 214

第一节 概说 Introduction 215

第二节 滋补肾阴方的分子机制 Molecular mechanism of Kidney Yin-tonic prescription 217

第三节 温肾补阳方的分子机制 Molecular mechanism of Kidney Yang-tonic prescription 220

第四节 益肾兼泻方的分子机制 Molecular mechanism of tonic-plus-dispelling prescription 224

第十五章 肿瘤的中医分子生物学研究 230

第一节 概说 Introduction 231

第二节 胃癌的中医分子机制研究 Molecular mechanism of TCM study on stomach cancer 232

第三节 肝癌的中医分子机制研究 Molecular mechanism of TCM study on liver cancer 235

第四节 白血病的中医分子机制研究 Molecular mechanism of TCM study on leukemia 237

第五节 鼻咽癌等中医分子机制研究 Molecular mechanism of TCM study on nasopharyngeal,carcinoma,etc 239

第十六章 红斑狼疮遗传背景及中医研究前瞻 245

第一节 概说 Introduction 246

第二节 狼疮遗传素质与先天肾本 Genetics backgrounds of SLE patients and their relationships with those of the congenital Kidney 248

第三节 红斑狼疮的病机及分子机制 Pathogenesis of SLE and its molecular mechanism of SLE 250

第四节 狼疮的HLA及转基因研究前瞻 The HLA pattern of SLE and transgene therapy 252

第五节 狼疮的亲子用药及中西医互补 Therapy on both parents and children by coordinated activities of TCM and western medicine on treatment of SLE 254

第十七章 老年痴呆的中医分子生物学研究前瞻 259

第一节 概说 Introduction 260

第二节 肾本-基因论老年痴呆的分子机制 Molecular mechanism of kidney-gene hypothesis upon the aged dementia 262

第三节 邪正观析老年痴呆成对指标 Evil-Right paired index analysis on the aged dementia 265

第四节 中医对痴呆的行为细胞及基因研究 Behavioral,cellular and genetic researches on aged dementia by meaning of TCM 267

第五节 肾本-基因论前瞻老年痴呆的研究 Prospect on the TCM molecular pharmacology study on the senior and aged dementia 270

第六节 基因芯片展示衰老鼠的基因表达谱 Microarray demonstration of the differential expressed gene profiles on the animals model of aged 271

第十八章 针灸的分子生物学研究及前瞻 279

第一节 概说 Introduction 280

第二节 针刺镇痛的分子机制研究 Molecular mechanism study on the acupuncture analgesia 281

第三节 针灸调节 神经免疫的分子机制 Molecular modulatory mechanism of the acupuncture effect on the neuro-immunology axle 284

第四节 针灸分子生物学研究的前瞻 Prospect of the molecular studies on the special therapy acupuncture 286

第五节 针刺衰老鼠涌泉穴的p53基因表达 The expression of p53 induced by acupuncture on the Yong-Quan point of aged model of mice 288

第十九章 “肾本遗传”研究(国家自然科学基金资助项目) 293

第一节 “肾为先天之本”实验的提案 Propose of the experiment study on the TCM principal that Kidney is the congenital fundamental of human being 294

第二节 肾本遗传的创新四论 The four novel theories of congenital fundamental of Kidney 297

第三节 先天行为与免疫学研究 Study on congenital behavior and immunology 298

第四节 肾本遗传的实验初阶 Primary studies on Kidney congenital genetics 300

第五节 肾本行为遗传的研究鉴定 Appraisal of the behavoiral genetic studies of congenital Kidney 301

第六节 肾本行为遗传的基因表达研究 Behavoiral gene expression pattern on congenital Kidney 304

第七节 肾阳虚证的基因芯片研究立论 Construct microarray approach on the differential expressed gene profiles of the Kidney Yang-deficiency 307

第二十章 中医分子流行病学发展前瞻 312

第一节 分子与人类基因组流行病学 Molecular and human genomic researches with epidemics 313

第二节 中医科学应切入分子流行病学 Requiring of TCM stepping into the molecular epidemics 315

第三节 中医流行病学现状横览 Updated conditions about the epidemics studies of TCM 317

第四节 分子流行病学调研示例 Investigation samples to show the methods of TCM epidemics 320

第五节 中医分子流行病学前瞻纵论 Prospect on the molecular approaching to TCM epidemics 322

第二十一章 天年长寿与基因 327

第一节 天年寿限与长寿基因 The life-span,longevity and longevity genes 328

第二节 长寿阴阳的时空有序展开 Deployment according to the special period and space programme of Yin-Yang theory with longevity 330

第三节 寿命环境与遗传基因 Coordinated of environmental factors and genes on longevity 332

第四节 远古至唐百岁老人的遗传与环境分析 Genetics and envirorment study on the cases from ancient to Tang dynasty 336

第五节 五代至清百岁老人的遗传与环境的分析 Genetics and envirorment study on the cases from Five dynasty to Qing dynasty 343

第六节 陈氏颖川支系智能遗传分析 Genetic analysis of family intelligent on Yingchuan division of Chen 348

第二十二章 养生延年与基因 354

第一节 易理寿限及遗传病 Longevity of the Theory YI and genetic diseases 355

第二节 中医抗衰老论及基因 TCM theory of the anti-aged and relevant genes 362

第三节 抗衰老方药及分子机制 Study on anti-aged Chinese medicine and molecular mechanism 365

第四节 太极气功养生及遗传禀赋 TCM regimen,Taiji and Qigong,and relationship with congenital character 367

第五节 三国皇族寿命及疾病的研究 Longevity patterns and disease research on the emperial families of the Three-kingdom Dynasty 370

第六节 宋帝贵族寿命及疾病的研究 Longevity pattern and disease research on the imperial and noble families of Song dynasty 375

第二十三章 中医分子生物学科研计划前瞻 383

第一节 脾肾藏象的分子生物学研究切入 The edge-cutting TCM projects about the Spleen and Kidney system in views of molecular biology 384

第二节 肾虚证候与基因谱的贯通研究 Series and breakthrough studies on the relationships between Kidney deficiency Syndrome and expressed gene profiles 386

第三节 针药补肾分子机制的同一性研究 Identification on the Molecular machanism of acupuncture compared with Chinese medicine 387

第四节 应激恐伤肾的母子基因谱比较Comparative studies on the expression gene profiles between the parents and offspring upon the panic stress mice model 389

第五节 先天补肾的分子遗传学研究 Pharmacological studies on the molecular mechanism of the therapy of Congenital Kidney supplement 391

第六节 抑制消减杂交筛选证-药的相关基因谱 Screening the Symdrome-drug relevant Gene Screeh by employing method of Suppress Subtractive Hybridization(SSH) 392

第七节 基因芯片研究肾虚证主效基因的战略 Microarray strategies on the screen of the major genes responed to Kidney deficiency 394

第二十四章 古代的基因猜想与前沿的实证研究 401

第一节 古代图谱远距离地猜测基因 Primordial hypothesis about gene derived from the remote figure 402

第二节 易理四象大跨度地推衍基因 Gene conjecture logically from the Theory YI and four-dimensional theory 406

第三节 经典理论高容量地涵盖基因 Classical theories included the idea of gene highly 414

第四节 c-fos基因表达研究应激肾虚 Research of the c-fos expression on the Kidney deficiency model mice which were induced by panic stress 422

第五节 抑制消减杂交初选肾阳虚的相关基因 Screen the Kidney Yang deficiency by utilizing method of Suppressed Subtractive Hybridization(SSH) 425

第六节 基因芯片探索针刺衰老鼠的循证研究 Evidence-dependent investigation on the microarray gene profile of the aged mice model treated by acupuncture 428