Development of the Cardiovascular System 1
Cardiogenesis in the Drosophila Model: Control Mechanisms during Early Induction and Diversification of Cardiac Progenitors S. Zaffran, X. Xu, P.C.H. Lo, H.-H. Lee, and M. Frasch 1
Regulation of Cardiac Muscle Differentiation in Xenopus laevis Embryos T. Mohun, B. Latinkic, N. Towers, and S. Kotecha 13
Genetic Regulation of Cardiac Patterning in Zebrafish D. Yelon, J.L. Feldman, and B.R. Keegan 19
Zebrafish Hearts and Minds: Nodal Signaling in Cardiac and Neural Left-Right Asymmetry S. Long, N. Ahmad, and M. Rebagliati 27
Cardiac Left-Right Development: Are the Early Steps Conserved? K.L. Kramer and H.J Yost 37
Erythropoietin and Retinoic Acid Signaling in the Epicardium Is Required for Cardiac Myocyte Proliferation I. Stuckmann and A.B. Lassar 45
Endocardial Cushion Formation in Zebrafish D.Y.R. Stainier, D. Beis, B. Jungblut, and T. Bartman 49
Neural Crest Migration and Mouse Models of Congenital Heart Disease A.D. Gitler, C.B. Brown, L. Kochilas, J. Li, and J.A. Epstein 57
Transcription Factors in Cardiovascular Development 63
Hey bHLH Factors in Cardiovascular Development A. Fischer, C. Leimeister, C. Winkler,N. Schumacher, B. Klamt, H. Elmasri, C. Steidl, M. Maier, K.-P. Knobeloch, K. Amann,A. Helisch, M. Sendtner, and M. Gessler 63
Molecular Mechanisms of Chamber-specific Myocardial Gene Expression: Transgenic Analysis of the ANF Promoter E.M. Small andP.A. Krieg 71
Pitx Genes during Cardiovascular Development C. Kioussi, P. Briata, S.H. Baek,A. Wynshaw-Boris, D.W. Rose, and M.G. Rosenfeld 81
Pitx2 and Cardiac Development: A Molecular Link between Left/Right Signaling and Congenital Heart Disease M. Campione, L. Acosta, S. Martinez, J.M. Icardo, A. Aranega,and D. Franco 89
Regulation of Cardiac Growth and Development by SRF and Its Cofactors D. Wang, R. Passier,Z.-P. Liu, C.H. Shin, Z. Wang, S. Li, L.B. Sutherland, E. Small, P.A. Krieg, and E.N. Olson 97
Homeodomain Factor Nkx2-5 in Heart Development and Disease R.P. Harvey, D. Lai, D. Elliott,C. Biben, M. Solloway, O. Prall, F. Stennard, A. Schindeler, N. Groves, L. Lavulo, C. Hyun,T. Yeoh, M. Costa, M. Furtado, and E. Kirk 107
Causes of Clinical Diversity in Human TBX5 Mutations T. Huang, J.E. Lock, A.C. Marshall,C. Basson, J.G. Seidman, and C.E. Seidman 115
Molecular Mechanisms of Ventricular Hypoplasia D. Srivastava, P.D. Gottlieb, and E.N. Olson 121
Hypoxia, HIFs, and Cardiovascular Development M.C. Simon, D. Ramirez-Bergeron, F. Mack,C.-J Hu, Y. Pan, and K. Mansfield 127
Quiescent Hypervascularity Mediated by Gain of HIF-ltx Function J.M. Arbeit 133
Vascular Biology 143
The Diverse Roles of Integrins and Their Ligands in Angiogenesis R.O.Hynes, J.C. Lively,J.H. McCarty, D. Taverna, S.E. Francis, K. Hodivala-Dilke, and Q. Xiao 143
Arteries, Veins, Notch, and VEGF B.M. Weinstein and N.D. Lawson 155
Cell Cycle Signaling and Cardiovascular Disease E.G. Nabel, M. Boehm, L.M. Akyurek, T. Yoshimoto, M.F. Crook, M. Olive, H. San, and X. Qu 163
Selective Functions of Angiopoietins and Vascular Endothelial Growth Factor on Blood Vessels: The Concept of"Vascular Domain" T.N. Sato, S. Loughna, E.C. Davis, R.P. Visconti, and C.D. Richardson 171
Survival Mechanisms of VEGF and PIGF during Microvascular Remodeling J.N. Upalakalin,I. Hemo, C. Dehio, E. Keshet, and L.E. Benjamin 181
Molecular Mechanisms of Lymphangiogenesis T. Makinen and K. Alitalo 189
Protease-activated Receptors in the Cardiovascular System S.R. Coughlin 197
Migration of Monocytes/Macrophages In Vitro and In Viva Is Accompanied by MMP 12-dependent Tunnel Formation and by Neovascularization M. Anghelina, A. Schmeisser, P. Krishnan, L. Moldovan, R.H. Strasser, and N.I. Moldovan 209
The Role of EG-VEGF in the Regulation of Angiogenesis in Endocrine Glands J. LeCouter, R. Lin, and N. Ferrara 217
Profiling the Molecular Diversity of Blood Vessels R. Pasqualini and W. Arap 223
Tumor Angiogenesis 227
VEGF-A Induces Angiogenesis, Arteriogenesis, Lymphangiogenesis, and Vascular Malformations J.A. Nagy, E. Vasile, D. Feng, C. Sundberg, L.F. Brown, E.J. Manseau, A.M. Dvorak, and H.F. Dvorak 227
Angiogenesis and Lymphangiogenesis in Tumors: Insights from Intravital Microscopy R.K. Jain 239
A Genetic Approach to Understanding Tumor Angiogenesis R. Benezra, P. de Candia, H. Li, E. Romero, D Lyden, S. Rafii, and M. Ruzinova 249
Discovery of Type IV Collagen Non-collagenous Domains as Novel Integfin Ligands and Endogenous Inhibitors of Angiogenesis R. Kalluri 255
Complementary and Coordinated Roles of the VEGFs and Angiopoietins during Normal and Pathologic Vascular Formation N. W. Gale, G. Thurston, S. Davis, S.J. Wiegand, J. Holash, J.S. Rudge, and G.D. Yancopoulos 267
Involvement of G Proteins in Vascular Permeability Factor/Vascular Endothelial Growth Factor Signaling D. Mukhopadhyay and H. Zeng 275
Targeted Delivery of Mutant Raf Kinase to Neovessels Causes Tumor Regression J.D. Hood and D.A. Cheresh 285
Combining Antiangiogenic Agents with Metronomic Chemotherapy Enhances Efficacy against Late-stage Pancreatic Islet Carcinomas in Mice G. Bergers and D. Hanahan 293
Genetics and Genomics of the Cardiovascular System 301
Zebrafish: The Complete Cardiovascular Compendium C.A. MacRae and M.C. Fishman 301
Consomic Rats for the Identification of Genes and Pathways Underlying Cardiovascular Disease R.J. Roman, A. W. Cowley, Jr., A. Greene, A.E. Kwitek, P.J. Tonellato, and H.J. Jacob 309
A Mouse Model of Congenital Heart Disease: Cardiac Arrhythrnias and Atrial Septal Defect Caused by Haploinsufticiency of the Cardiac Transcription Factor Csx/Nkx2.5 M. Tanaka,C.I. Berul, M. Ishii, P.Y. Jay, H. Wakaimoto, P. Douglas, N. Yamasaki, T. Kawamoto,J. Gehrmann, C.T. Maguire, M. Schinke, C.E. Seidman, J.G. Seidman, Y. Kurachi, and S. Izumo 317
Genetic Dissection of the DiGeorge Syndrome Phenotype F. Vitelli, E.A. Lindsay, and A. Baldini 327
A Missense Mutation in a Highly Conserved Region of CASQ2 Is Associated with AutosomalRecessive Catecholamine-induced Polymorphic Ventricular Tachycardia in Bedouin Families from Israel M. Eldar, E. Pros, and H. Lahat 333
Regulation of the Heart 339
Calcium-dependent Gene Regulation in Myocyte Hypertrophy and Remodeling R.S. Williams and P. Rosenberg 339
A Gradient of Myosin Regulatory Light-chain Phosphorylation across the Ventricular Wall Supports Cardiac Torsion J.S. Davis, S. Hassanzadeh, S. Winitsky, H. Wen, A. Aletras, and N.D. Epstein 345
Molecular and Functional Maturation of the Murine Cardiac Conduction System S. Rentschler, G.E. Morley, and G.I. Fishman 353
The Yin/Yang of Innate Stress Responses in the Heart D.L. Mann 363
Regulatory Networks Controlling Mitochondrial Energy Production in the Developing, Hypertrophied, and Diabetic Heart B.N. Finck, J.J. Lehman, P.M. Barger, and D.P. Kelly 371
Heart Disease and Failure 383
Molecular Epidemiology of Hypertrophic Cardiomyopathy H. Morita, S.R. DePalma, M. Arad, B. McDonough, S. Barr, C. Duffy, B.J. Maron, C.E. Seidman, and J.G. Seidman 383
The Sarcoglycan Complex in Striated and Vascular Smooth Muscle M.T. Wheeler, M.J. AlliKian, A. Heydemann, and E.M. McNally 389
The MLP Family of Cytoskeletal Z Disc Proteins and Dilated Cardiomyopathy: A Stress Pathway Model for Heart Failure Progression M. Hoshijima, M. Pashmforoush, R. Knoll, and K.R. Chien 399
From Sarcomeric Mutations to Heart Disease: Understanding Familial Hypertrophic Cardiomyopathy A. Maass, J.P. Konhilas, B.L. Stauffer, and L.A. Leinwand 409
Vascular Endothelium in Tissue Remodeling: Implications for Heart Failure S.M. Dallabrida and M.A. Rupnick 417
Using a Gene-switch Transgenic Approach to Dissect Distinct Roles of MAP Kinases in Heart Failure B.G. Petrich, P. Liao, and Y. Wang 429
G-Protein-coupled Receptor Function in Heart Failure S.V. Naga Prasad, J. Nienaber, and H.A. Rockman 439
Hypertension, Atherosclerosis, and Lipid Homeostasis 445
Salt and Blood Pressure: New Insight from Human Genetic Studies R.P. Lifton, F.H. Wilson, K.A. Choate, and D.S. Geller 445
Gene-targeting Studies of the Renin-Angiotensin System: Mechanisms of Hypertension and Cardiovascular Disease S.B. Gurley, T.H. Le, and T.M. Coffman 451
Modulation of Endothelial NO Production by High-density Lipoprotein C. Mineo and P.W. Shaul 459
Plaque Angiogenesis: Its Functions and Regulation K.S. Moulton 471
Extracellular Superoxide Dismutase, Uric Acid, and Atherosclerosis H.U. Hink and T. Fukai 483
SREBPs: Transcriptional Mediators of Lipid Homeostasis J.D. Horton, J.L. Goldstein, and M.S. Brown 491
Genetic Defenses against Hypercholesterolemia H.H. Hobbs, G.A. Graf, L. Yu, K.R. Wilund, and J.C Cohen 499
Repairing the Cardiovascular System 507
Insulin-like Growth Factor Isoforms in Skeletal Muscle Aging, Regeneration, and Disease N. Winn, A. Paul, A. Musaro, and N. Rosenthal 507
Cellular Therapies for Myocardial Infarct Repair C.E. Murry, M.L. Whitney, M.A. Laflamme, H. Reinecke, and L.J. Field 519
Gene Therapy for Cardiac Arrhythmias E. Marban, H.B. Nuss, and J.K. Donahue 527
Myocardial Disease in Failing Hearts: Defective Excitation-Contraction Coupling X.H.T. Wehrens and A.R. Marks 533
Summary: The Coming of Age of Cardiovascular Science C.E. Seidman and J.G. Seidman 543
Author Index 551
Subject Index 553