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Development of the Cardiovascular System 1

Cardiogenesis in the Drosophila Model: Control Mechanisms during Early Induction and Diversification of Cardiac Progenitors S. Zaffran, X. Xu, P.C.H. Lo, H.-H. Lee, and M. Frasch 1

Regulation of Cardiac Muscle Differentiation in Xenopus laevis Embryos T. Mohun, B. Latinkic, N. Towers, and S. Kotecha 13

Genetic Regulation of Cardiac Patterning in Zebrafish D. Yelon, J.L. Feldman, and B.R. Keegan 19

Zebrafish Hearts and Minds: Nodal Signaling in Cardiac and Neural Left-Right Asymmetry S. Long, N. Ahmad, and M. Rebagliati 27

Cardiac Left-Right Development: Are the Early Steps Conserved? K.L. Kramer and H.J Yost 37

Erythropoietin and Retinoic Acid Signaling in the Epicardium Is Required for Cardiac Myocyte Proliferation I. Stuckmann and A.B. Lassar 45

Endocardial Cushion Formation in Zebrafish D.Y.R. Stainier, D. Beis, B. Jungblut, and T. Bartman 49

Neural Crest Migration and Mouse Models of Congenital Heart Disease A.D. Gitler, C.B. Brown, L. Kochilas, J. Li, and J.A. Epstein 57

Transcription Factors in Cardiovascular Development 63

Hey bHLH Factors in Cardiovascular Development A. Fischer, C. Leimeister, C. Winkler,N. Schumacher, B. Klamt, H. Elmasri, C. Steidl, M. Maier, K.-P. Knobeloch, K. Amann,A. Helisch, M. Sendtner, and M. Gessler 63

Molecular Mechanisms of Chamber-specific Myocardial Gene Expression: Transgenic Analysis of the ANF Promoter E.M. Small andP.A. Krieg 71

Pitx Genes during Cardiovascular Development C. Kioussi, P. Briata, S.H. Baek,A. Wynshaw-Boris, D.W. Rose, and M.G. Rosenfeld 81

Pitx2 and Cardiac Development: A Molecular Link between Left/Right Signaling and Congenital Heart Disease M. Campione, L. Acosta, S. Martinez, J.M. Icardo, A. Aranega,and D. Franco 89

Regulation of Cardiac Growth and Development by SRF and Its Cofactors D. Wang, R. Passier,Z.-P. Liu, C.H. Shin, Z. Wang, S. Li, L.B. Sutherland, E. Small, P.A. Krieg, and E.N. Olson 97

Homeodomain Factor Nkx2-5 in Heart Development and Disease R.P. Harvey, D. Lai, D. Elliott,C. Biben, M. Solloway, O. Prall, F. Stennard, A. Schindeler, N. Groves, L. Lavulo, C. Hyun,T. Yeoh, M. Costa, M. Furtado, and E. Kirk 107

Causes of Clinical Diversity in Human TBX5 Mutations T. Huang, J.E. Lock, A.C. Marshall,C. Basson, J.G. Seidman, and C.E. Seidman 115

Molecular Mechanisms of Ventricular Hypoplasia D. Srivastava, P.D. Gottlieb, and E.N. Olson 121

Hypoxia, HIFs, and Cardiovascular Development M.C. Simon, D. Ramirez-Bergeron, F. Mack,C.-J Hu, Y. Pan, and K. Mansfield 127

Quiescent Hypervascularity Mediated by Gain of HIF-ltx Function J.M. Arbeit 133

Vascular Biology 143

The Diverse Roles of Integrins and Their Ligands in Angiogenesis R.O.Hynes, J.C. Lively,J.H. McCarty, D. Taverna, S.E. Francis, K. Hodivala-Dilke, and Q. Xiao 143

Arteries, Veins, Notch, and VEGF B.M. Weinstein and N.D. Lawson 155

Cell Cycle Signaling and Cardiovascular Disease E.G. Nabel, M. Boehm, L.M. Akyurek, T. Yoshimoto, M.F. Crook, M. Olive, H. San, and X. Qu 163

Selective Functions of Angiopoietins and Vascular Endothelial Growth Factor on Blood Vessels: The Concept of"Vascular Domain" T.N. Sato, S. Loughna, E.C. Davis, R.P. Visconti, and C.D. Richardson 171

Survival Mechanisms of VEGF and PIGF during Microvascular Remodeling J.N. Upalakalin,I. Hemo, C. Dehio, E. Keshet, and L.E. Benjamin 181

Molecular Mechanisms of Lymphangiogenesis T. Makinen and K. Alitalo 189

Protease-activated Receptors in the Cardiovascular System S.R. Coughlin 197

Migration of Monocytes/Macrophages In Vitro and In Viva Is Accompanied by MMP 12-dependent Tunnel Formation and by Neovascularization M. Anghelina, A. Schmeisser, P. Krishnan, L. Moldovan, R.H. Strasser, and N.I. Moldovan 209

The Role of EG-VEGF in the Regulation of Angiogenesis in Endocrine Glands J. LeCouter, R. Lin, and N. Ferrara 217

Profiling the Molecular Diversity of Blood Vessels R. Pasqualini and W. Arap 223

Tumor Angiogenesis 227

VEGF-A Induces Angiogenesis, Arteriogenesis, Lymphangiogenesis, and Vascular Malformations J.A. Nagy, E. Vasile, D. Feng, C. Sundberg, L.F. Brown, E.J. Manseau, A.M. Dvorak, and H.F. Dvorak 227

Angiogenesis and Lymphangiogenesis in Tumors: Insights from Intravital Microscopy R.K. Jain 239

A Genetic Approach to Understanding Tumor Angiogenesis R. Benezra, P. de Candia, H. Li, E. Romero, D Lyden, S. Rafii, and M. Ruzinova 249

Discovery of Type IV Collagen Non-collagenous Domains as Novel Integfin Ligands and Endogenous Inhibitors of Angiogenesis R. Kalluri 255

Complementary and Coordinated Roles of the VEGFs and Angiopoietins during Normal and Pathologic Vascular Formation N. W. Gale, G. Thurston, S. Davis, S.J. Wiegand, J. Holash, J.S. Rudge, and G.D. Yancopoulos 267

Involvement of G Proteins in Vascular Permeability Factor/Vascular Endothelial Growth Factor Signaling D. Mukhopadhyay and H. Zeng 275

Targeted Delivery of Mutant Raf Kinase to Neovessels Causes Tumor Regression J.D. Hood and D.A. Cheresh 285

Combining Antiangiogenic Agents with Metronomic Chemotherapy Enhances Efficacy against Late-stage Pancreatic Islet Carcinomas in Mice G. Bergers and D. Hanahan 293

Genetics and Genomics of the Cardiovascular System 301

Zebrafish: The Complete Cardiovascular Compendium C.A. MacRae and M.C. Fishman 301

Consomic Rats for the Identification of Genes and Pathways Underlying Cardiovascular Disease R.J. Roman, A. W. Cowley, Jr., A. Greene, A.E. Kwitek, P.J. Tonellato, and H.J. Jacob 309

A Mouse Model of Congenital Heart Disease: Cardiac Arrhythrnias and Atrial Septal Defect Caused by Haploinsufticiency of the Cardiac Transcription Factor Csx/Nkx2.5 M. Tanaka,C.I. Berul, M. Ishii, P.Y. Jay, H. Wakaimoto, P. Douglas, N. Yamasaki, T. Kawamoto,J. Gehrmann, C.T. Maguire, M. Schinke, C.E. Seidman, J.G. Seidman, Y. Kurachi, and S. Izumo 317

Genetic Dissection of the DiGeorge Syndrome Phenotype F. Vitelli, E.A. Lindsay, and A. Baldini 327

A Missense Mutation in a Highly Conserved Region of CASQ2 Is Associated with AutosomalRecessive Catecholamine-induced Polymorphic Ventricular Tachycardia in Bedouin Families from Israel M. Eldar, E. Pros, and H. Lahat 333

Regulation of the Heart 339

Calcium-dependent Gene Regulation in Myocyte Hypertrophy and Remodeling R.S. Williams and P. Rosenberg 339

A Gradient of Myosin Regulatory Light-chain Phosphorylation across the Ventricular Wall Supports Cardiac Torsion J.S. Davis, S. Hassanzadeh, S. Winitsky, H. Wen, A. Aletras, and N.D. Epstein 345

Molecular and Functional Maturation of the Murine Cardiac Conduction System S. Rentschler, G.E. Morley, and G.I. Fishman 353

The Yin/Yang of Innate Stress Responses in the Heart D.L. Mann 363

Regulatory Networks Controlling Mitochondrial Energy Production in the Developing, Hypertrophied, and Diabetic Heart B.N. Finck, J.J. Lehman, P.M. Barger, and D.P. Kelly 371

Heart Disease and Failure 383

Molecular Epidemiology of Hypertrophic Cardiomyopathy H. Morita, S.R. DePalma, M. Arad, B. McDonough, S. Barr, C. Duffy, B.J. Maron, C.E. Seidman, and J.G. Seidman 383

The Sarcoglycan Complex in Striated and Vascular Smooth Muscle M.T. Wheeler, M.J. AlliKian, A. Heydemann, and E.M. McNally 389

The MLP Family of Cytoskeletal Z Disc Proteins and Dilated Cardiomyopathy: A Stress Pathway Model for Heart Failure Progression M. Hoshijima, M. Pashmforoush, R. Knoll, and K.R. Chien 399

From Sarcomeric Mutations to Heart Disease: Understanding Familial Hypertrophic Cardiomyopathy A. Maass, J.P. Konhilas, B.L. Stauffer, and L.A. Leinwand 409

Vascular Endothelium in Tissue Remodeling: Implications for Heart Failure S.M. Dallabrida and M.A. Rupnick 417

Using a Gene-switch Transgenic Approach to Dissect Distinct Roles of MAP Kinases in Heart Failure B.G. Petrich, P. Liao, and Y. Wang 429

G-Protein-coupled Receptor Function in Heart Failure S.V. Naga Prasad, J. Nienaber, and H.A. Rockman 439

Hypertension, Atherosclerosis, and Lipid Homeostasis 445

Salt and Blood Pressure: New Insight from Human Genetic Studies R.P. Lifton, F.H. Wilson, K.A. Choate, and D.S. Geller 445

Gene-targeting Studies of the Renin-Angiotensin System: Mechanisms of Hypertension and Cardiovascular Disease S.B. Gurley, T.H. Le, and T.M. Coffman 451

Modulation of Endothelial NO Production by High-density Lipoprotein C. Mineo and P.W. Shaul 459

Plaque Angiogenesis: Its Functions and Regulation K.S. Moulton 471

Extracellular Superoxide Dismutase, Uric Acid, and Atherosclerosis H.U. Hink and T. Fukai 483

SREBPs: Transcriptional Mediators of Lipid Homeostasis J.D. Horton, J.L. Goldstein, and M.S. Brown 491

Genetic Defenses against Hypercholesterolemia H.H. Hobbs, G.A. Graf, L. Yu, K.R. Wilund, and J.C Cohen 499

Repairing the Cardiovascular System 507

Insulin-like Growth Factor Isoforms in Skeletal Muscle Aging, Regeneration, and Disease N. Winn, A. Paul, A. Musaro, and N. Rosenthal 507

Cellular Therapies for Myocardial Infarct Repair C.E. Murry, M.L. Whitney, M.A. Laflamme, H. Reinecke, and L.J. Field 519

Gene Therapy for Cardiac Arrhythmias E. Marban, H.B. Nuss, and J.K. Donahue 527

Myocardial Disease in Failing Hearts: Defective Excitation-Contraction Coupling X.H.T. Wehrens and A.R. Marks 533

Summary: The Coming of Age of Cardiovascular Science C.E. Seidman and J.G. Seidman 543

Author Index 551

Subject Index 553