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目录 1

自述 1

［附］为中青年科技人员的想象力和创造力插上翅膀 7

科研论著 13

PLZF-RARα Fusion Proteins Generated from the Variant t（11；17）（q23；q21）Translocation in Acute Promyelocytic Leukemia Inhibit Liganddependent Transactivation of Wild-type Retinoic Acid Receptors 15

Acute Promyelocytic Leukemia：From Clinic to Molecular Biology 32

人类YAC库PCR三维筛选体系的建立及质量考核 58

RIG-E，a Human Homolog of the Murine Ly-6 Family，is Induced by Retinoic Acid during the Differentiation of Acute Promyelocytic Leukemia Cell 67

Retinoic Acid Regulatory Pathways，Chromosomal Transloca-tions，and Acute Promyelocytic Leukemia 83

急性非淋巴细胞白血病的细胞遗传学及其预后意义 114

Use of Arsenic Trioxide（As2O3）in the Treatment of Acute Promyelocytic Leukemia（APL）：Ⅰ．As2O3 Exerts Dose-Dependent Dual Effects on APL Cells 120

Use of Arsenic Trioxide（As2 O3）in the Treatment of Acute Promyelocytic Leukemia（APL）：Ⅱ ．Clinical Efficacy and Pharmacokinetics in Relapsed Patients 149

Cloning of a Gene（RIG-G）Associated with Retinoic Acid-induced Differentiation of Acute Promyelocytic Leukemia 170

Cells and Representing a New Member of a Family of Interferon-stimulated Genes 170

人类基因组和白血病的细胞分化与凋亡诱导 191

Identification of Genes Expressed in Human CD34+ Hemato-poietic Stem/Progenitor Cells by Expressed Sequence Tags and Efficient Full-length cDNA Cloning 201

Chromosomal Aberrations during Progression of Chronic Myeloid Leukemia Identified by Cytogenetic and Molecular Cytogenetic Tools：Implication of 1q12-21 226

论著目录 245