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有机化学中的生物转化  第6版  英文
有机化学中的生物转化  第6版  英文

有机化学中的生物转化 第6版 英文PDF电子书下载

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  • 电子书积分:14 积分如何计算积分?
  • 作 者:(奥)费伯(Faberk)著
  • 出 版 社:上海:世界图书上海出版公司
  • 出版年份:2014
  • ISBN:9787510078729
  • 页数:424 页
图书介绍:本书是一部本科生和研究生学习生物催化剂的入门教程,这是第6版,其畅销程度可见一斑。生物催化剂的应用,既可以是独立的酶,或者是单独的微生物细胞,提供了精心挑选的先进的合成有机物化学的的转化。在过去的几十年,该方法成为非对称合成的必不可少的工具,不仅在学术层面,也在规模工业方面。本书在简单介绍了生物催化剂的应用—立体选择性转化原理、酶的性质和运动—之后,根据反应原理介绍了不同类型的反映。目次:引论和背景信息;生物催化剂应用;特别技巧;当前状态和前景;附录。读者对象:有机化学的专业的本科生。
《有机化学中的生物转化 第6版 英文》目录

1 Introduction and Background Information 1

1.1 Introduction 1

1.2 Common Prejudices Against Enzymes 2

1.3 Advantages and Disadvantages of Biocatalysts 3

1.3.1 Advantages of Biocatalysts 3

1.3.2 Disadvantages of Biocatalysts 7

1.3.3 Isolated Enzymes vs.Whole Cell Systems 9

1.4 Enzyme Properties and Nomenclature 11

1.4.1 Structural Biology in a Nutshell 11

1.4.2 Mechanistic Aspects of Enzyme Catalysis 13

1.4.3 Classification and Nomenclature 23

1.4.4 Coenzymes 26

1.4.5 Enzyme Sources 27

References 27

2 Biocatalytic Applications 31

2.1 Hydrolytic Reactions 31

2.1.1 Mechanistic and Kinetic Aspects 31

2.1.2 Hydrolysis of the Amide Bond 51

2.1.3 Ester Hydrolysis 60

2.1.4 Hydrolysis and Formation of Phosphate Esters 111

2.1.5 Hydrolysis of Epoxides 120

2.1.6 Hydrolysis of Nitriles 130

2.2 Reduction Reactions 139

2.2.1 Recycling of Cofactors 140

2.2.2 Reduction of Aldehydes and Ketones Using Isolated Enzymes 145

2.2.3 Reduction of Aldehydes and Ketones Using Whole Cells 153

2.2.4 Reduction of C=C-Bonds 166

2.3 Oxidation Reactions 173

2.3.1 Oxidation of Alcohols and Aldehydes 173

2.3.2 Oxygenation Reactions 176

2.3.3 Peroxidation Reactions 204

2.4 Formation of Carbon-Carbon Bonds 211

2.4.1 Aldol Reactions 211

2.4.2 Thiamine-Dependent Acyloin and Benzoin Reactions 225

2.4.3 Michael-Type Additions 231

2.5 Addition and Elimination Reactions 233

2.5.1 Cyanohydrin Formation 233

2.5.2 Addition of Water 237

2.5.3 Addition of Ammonia 240

2.6 Transfer Reactions 242

2.6.1 Glycosyl Transfer Reactions 242

2.6.2 Amino Transfer Reactions 254

2.7 Halogenation and Dehalogenation Reactions 257

2.7.1 Hálogenation 258

2.7.2 Dehalogenation 263

References 268

3 Special Techniques 315

3.1 Enzymes in Organic Solvents 315

3.1.1 Ester Synthesis 324

3.1.2 Lactone Synthesis 342

3.1.3 Amide Synthesis 343

3.1.4 Peptide Synthesis 346

3.1.5 Peracid Synthesis 351

3.1.6 Redox Reactions 352

3.1.7 Medium Engineering 354

3.2 Immobilization 356

3.3 Artificial and Modified Enzymes 367

3.3.1 Artificial Enzyme Mimics 367

3.3.2 Modified Enzymes 368

3.3.3 Catalytic Antibodies 373

References 377

4 State of the Art and Outlook 391

References 396

5 Appendix 397

5.1 Basic Rules for Handling Biocatalysts 397

5.2 Abbreviations 400

5.3 Suppliers of Enzymes 401

5.4 Commonly Used Enzyme Preparations 402

5.5 Major Culture Collections 404

5.6 Pathogenic Bacteria and Fungi 405

Index 407

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