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PART Ⅰ Science of Clinical Oncology 3

SECTION 1 Genetic Basis of Cancer 3

1．Structure and Function of the Gene&Jeffrey Ross 3

2．Regulation of the Cell Cycle&Atul Bedi and Michael B.Kastan 10

3．Cancer Biology:Invasion and Metastasis&Isaiab J.Fidler 29

4．Genes and Cancer:Risk Determinants and Agents of Change&William F.Dove 54

5．Oncogenes and Tumor Suppressor Genes&Eric R.Fearon 77

6．Molecular Diagnostic Methods in Cancer Genetics&Russell F.Jacoby and Carolyn E.Cole 119

7．Genetics in Clinical Oncology&Kenneth Offit 138

SECTION 2 Immunologic Basis of Cancer 158

8．T-Lymphocyte Responses&Thierry Boon,Pierre G.Coulie,Pierre van der Bruggen,and Nicolas yan Baren 158

9．B-Lymphocyte Responses&Michael J.Campbell and John E.Niederhuber 174

10．Immunodeficiency and Cancer&Alexandra H.Filipovich and Michael S.Grimley 200

11．Tumor Immunology and Immunotherapy&Mark R.Albertini and Paul M.Sondel 214

12．New Developmental Therapies&John L.Marshall,Naiyer A.Rizvi,Pankaj Bhargava,Slawomir Wojtowicz-Praga,and Michael J.Hawkins 242

SECTION 3 Environmental Basis of Cancer 279

13．Chemical and Physical Agents in Our Environment&Paul T.Strickland and Thomas W.Kensler 279

14．Tumor Viruses&Elliott Kieff 298

SECTION 4 Principles of Prevention,Diagnosis,and Therapy 318

15．Cancer Prevention&Kristin A.Keefe and Frank L.Meyskens,Jr 318

16．Economic Analysis of Cancer Treatment&Charles L.Bennett,Bruce E.Hillner,and Thomas J.Smith 366

17．Chemotherapy&Michael C.Perry,Clay M.Anderson,and Ross C.Donehower 378

18．Radiation Therapy&Allen S.Lichter 423

19．Surgical Therapy&John E.Niederhuber 471

20．Bone Marrow Transplantation&Julie M.Vose,Anne Kessinger,Michael R.Bishop,Elizabeth C.Reed,Stefano Tarantolo,Philip J.Bierman,and James O.Armitage 482

SECTION 5 Understanding Risk 494

21．Epidemiology&David Schottenfeld 494

22．Biostatistics for Clinical Trials&Steven Piantadosi 519

PART Ⅱ Problems Common to Cancer and Its Therapy 539

SECTION 1 General Problems 539

23．Cancer Pain&Stuart A.Grossman and Vivian R.Sheidler 539

24．Psychological Distress and Depression&J.Stephen McDaniel,Dominique L.Musselman,and Charles B.Nemeroff 556

25．Weight Loss and Cachexia&Michael M.Meguid and Alessandro Laviano 579

26．The Terminally Ill Patient&Barry M.Kinzbrunner 597

SECTION 2 Hematologic Problems 628

27．Disorders of Blood Cell Production in Clinical Oncology&George D.Demetri and Kenneth C.Anderson 628

28．Thrombotic Complications&William D.Haire 657

SECTION 3 Infections 690

29．Fever in the Neutropenic Patient&Gerald P.Bodey 690

30．Fever in the Patient Without Neutropenia&Edward A.Dominguez,Mark E.Rupp,and Laurel C.Preheim 707

SECTION 4 Metabolic Problems 719

31．Hypercalcemia&A.Ross Morton and Allan Lipton 719

32．Hyponatremia&Jesse M.Goldman and Robert L.Comis 736

33．Tumor Lysis Syndrome&Michael R.Bishop and Peter F.Coccia 750

SECTION 5 Surgical Problems 755

34．Establishing and Maintaining Vascular Access&William C.Dooley and John E.Niederhuber 755

35．Acute Abdomen,Bowel Obstruction,and Fistula&Alan M.Yabanda and Alfred E.Chang 776

SECTION 6 Local Effects of Cancer and Its Metastasis 797

36．Superior Vena Cava Syndrome&Anthony J.Cmelak,John Roberts,Steven G.Meranze,and David H.Johnson 797

37．Spinal Cord Compression&John C.Ruckdeschel 811

38．Brain Metastases and Carcinomatous Meningitis&Roy A.Patchell 820

39．Bone Metastases&R.E.Coleman and R.D.Rubens 836

40．Lung Metastases&Ugo Pastorino,Patricia M.McCormack,and Robert J.Ginsberg 872

41．Liver Metastases&Nancy E.Kemeny,Margaret Kemeny,and Theodore S.Lawrence 886

42．Effusions&Irfan Maghfoor,Donald C.Doll,and John Yarbro 922

43．Nausea and Vomiting&John D.Hainsworth 950

44．Oral Complications&Charles L.Loprinzi,Dennis A.Gastineau,and Robert L.Foote 965

45．Alopecia and Cutaneous Complications&Charles J.McDonald,Jennie J.Muglia,and Carmela C.Vittorio 980

46．Neurologic Complications&Mark R.Gilbert 1000

47．Pulmonary Complications&Sandra McDonald,George C.Garrow and Philip Rubin 1023

48．Cardiac Complications&James L.Speyer and Robin S.Freedberg 1047

49．Reproductive Complications&G.Scott Long and Donald L.Trump 1061

50．Endocrine Complications&G.Scott Long and Donald L.Trump 1074

51．Second Malignant Neoplasms&Daniel M.Green and Giulio J.D'Angio 1082

PART Ⅲ Specific Malignancies 1103

52．Central Nervous System&William R.Shapiro,Joan Rankin Shapiro,and Russell W.Walker 1103

53．Eye,Orbit,and Adnexal Structures&Victor M.Elner,David S.Bardenstein,and Allen S.Lichter 1193

54．Head and Neck&Roger Stupp,Theodore D.K.Chung,Sharon L.Collins,Michael J.Dougberty,Ralph R.Weichselbaum,and Everett E.Vokes 1248

55．Skin:Malignant Melanoma&Lynn M.Schuchter,Frank Haluska,Douglas Fraker,and Rosalie Elenitsas 1317

Nonmelanoma Skin Cancers:Basal Cell and Squamous Cell Carcinoma&Jonathan Wolfe 1351

56．Endocrine System&John S.Macdonald,Daniel Haller,I.Ross McDougall,and Ronald J.Weigel 1360

57．Lung&Ronald Feld,Robert J.Ginsberg,David G.Payne,and Frances A.Shepherd 1398

58．Pleura and Mediastinum&Joseph Aisner,Karen H.Antman,and Chandra P.Belani 1478

59．Esophagus&Rich ard F.Heitmiller,Arlene A.Forastiere,and Lawronce R.Kleinberg 1517

60．Stomach&Leonard L.Gunderson,John H.Donohue,and Patrick A.Burch 1545

61．Small Bowel&David M.Mahvi and James Stone 1586

62．Colon and Rectum&Bruce A.Harms,Louise Grochow,John E.Niederhuber,and Mark A.Ritter 1611

63．Anal Canal&Elizabeth Poplin,Laurie E.Gaspar,and Daniel G.Sheehan 1661

64．Liver and Bile Ducts&Kevin T.Watkins and Steven A.Curley 1681

65．Pancreas&J.Augusto Bastidas,Joseph C.Poen,and John E.Niederhuber 1749

66．Kidney and Ureter&Jonathan W.Simons and Fray F.Marshall 1784

67．Carcinoma of the Bladder&James E.Montie,David C.Smith,and Howard M.Sandler 1800

68．Prostate Cancer&Howard L.Scher,John T.Isaacs,Michael J.Zelefsky,and Peter T.Scardino 1823

69．Penis and Urethra&Curtis A.Pettaway,M.Derya Balbay,and H.Barton Grossman 1885

70．Testes&Eric J.Small and Frank M.Torti 1906

71．Cervix,Vulva,and Vagina&John C.Elkas,Robin Farias-Eisner,and Jonathan S.Berek 1946

72．Uterus&Lowell J.Byers,Jeffrey M.Fowler,and Leo B.Twiggs 1987

73．Ovaries and Fallopian Tubes&James Tate Thigpen 2016

74．Gestational Trophoblastic Disease&Vicki V.Baker 2041

75．Breast&Martin D.Abeloff,Allen S.Lichter,John E.Niederhuber,Lori J.Pierce,and Richard R.Love 2051

76．Sarcomas of Bone&Julia A.Bridge,Herbert S.Schwartz,and James R.Neff 2160

77．Sarcomas of Soft Tissue&Peter W.T.Pisters and Murray F.Brennan 2273

78．Carcinoma of Unknown Primary&James L.Abbruzzese,Renato Lenzi,and Martin N.Raber 2314

79．HIV-Associated Malignancies:Kaposi's Sarcoma and Lymphoma&Ian W.Flinn and Richard F.Ambinder 2330

80．Pediatric Tumors&Alberto S.Pappo,Carlos Rodriguez-Galindo,Jeffrey S.Dome,and Victor M.Santana 2346

81．Childhood Leukemias&Theodore F.Zipf,Stacey Lynn Berg,W.Mark Roberts,David G.Poplack,C.Philip Steuber,and W.Archie Bleyer 2402

82．Childhood Lymphoma&John T.Sandlund 2435

83．Adult Acute Lymphoblastic Leukemia&Wendy Stock,John C.Byrd,Stanley R.Frankel,and Clara D.Bloomfield 2451

84．Acute Myeloid Leukemia in Adults&Richard M.Stone and Robert J.Mayer 2490

85．The Myelodysplastic Syndromes&Peter A.Kouides and John M.Bennett 2511

86．Chronic Lymphocytic Leukemias&Bruce D.Cheson 2536

87．Hairy Cell Leukemia&Martin S.Tallman,David Hakimian,and LoAnn C.Peterson 2564

88．Chronic Myeloid Leukemia&Agnes Yong and John M.Goldman 2579

89．Multiple Myeloma and Related Disorders&Robert A.Kyle and Joan Bladé 2597

90．Hodgkin's Disease&Dwight Kaufman and Dan L.Longo 2620

91．Non-Hodgkin's Lymphomas&T.Andrew Lister and James O.Armitage 2658

92．Cutaneous T-Cell Lymphoma&Thomas M.Habermann and Mark R.Pittelkow 2720

93．Adult T-Cell Leukemia-Lymphoma&Kensei Tobinai 2748

PART Ⅳ Rehabilitation of the Cancer Patient 2771

94．Physical Rehabilitation&Richard S.Tunkel,Elisabeth Lachmann,Patrick J.Boland,and Margaret L.Ho 2771

95．Evaluation and Management of Sexual Dysfunction&Sarah S.Auchincloss and Andrea B.Hamilton 2818

96．Psychosocial Rehabilitation&James R.Zabora,Matthew J.Loscalzo,and Elizabeth D.Smith 2845

Index 2867